Distribution and photodynamic effects of meso-tetrahydroxyphenylclhlorin (mTHPC) in the pancreas and adjacent tissues in the Syrian golden hamster

British Journal of Cancer

Volumn 73, Issue 12, 1996, Pages 1473-1479

  Mlkvy, P ^a   Messmann, H ^b   Pauer, M ^a   Stewart, J C M ^c   Millson, C E ^d   MacRobert, A J ^d   Bown, S G ^d  

^a CANCER RESEARCH INSTITUTE   (Slovakia)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c Scotia Pharmaceuticals   (United Kingdom)

^d ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Bile duct; Duodenum; Pancreas; Photodynamic therapy; Stomach

Indexed keywords

PHOTOSENSITIZING AGENT;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DUODENUM PERFORATION; FLUORESCENCE MICROSCOPY; INTESTINE NECROSIS; NONHUMAN; PANCREAS NECROSIS; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; STOMACH; SYRIAN HAMSTER; TISSUE DISTRIBUTION; WOUND HEALING;

EID: 0030018765     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.279     Document Type: Article

References (33)

1. ABULAFI AM, ALLARDICE JT, WILLIAMS NS, VAN SOMEREN N, SWAIN CP AND AINLEY CA. (1995). Photodynamic therapy for malignant tumours of the ampulla of Vater. Gut, 36, 853-856.
2. BARR H, TRALAU CJ, BOULOS PB, MACROBERT AJ, TILLY R AND BOWN SG. (1987). The contrasting mechanisms of colonic collagen damage between photodynamic therapy and thermal injury. Photochem. Photobiol., 46, 795-800.
3. BARR H, TRALAU CJ, BOULOS PB, MACROBERT AJ, KRASNER N, PHILLIPS D AND BOWN SG. (1990). Selective necrosis in dimethylhydrazine induced rat colon tumours using phthalocyanine photodynamic therapy. Gastroenterology, 98, 1532-1537.
4. BARR H, CHATLANI P, TRALAU CJ, MACROBERT AJ, BOULOS PB AND BOWN SG. (1991). Local eradication of rat colon cancer with photodynamic therapy: Correlation of distribution of photosensitiser with biological effects in normal and tumour tissues. Gut, 32, 517-523.
5. BERENBAUM MC, AKANDE SL, BONNETT R AND KAUR H. (1986). meso Tetra (hydroxyphenyl) porphyrins, a new class of potent tumour photosensitiser with favourable selectivity. Br. J. Cancer, 54, 717-725.
6. BERENBAUM MC, BONNETT R, CHEVRETTON EB, AKANDE-ADEBAKIN SL AND RUSTON M. (1993). Selectivity of meso Tetra (hydroxyphenyl) porphyrins and chlorins and of Photofrin II in causing photodamage in tumours, skin, muscle and bladder. The concept of cost benefit in analysing the results. Lasers Med. Sci., 8, 235-243.
7. BONNETT R. (1993). Morris Berenbaum an appreciation. Lasers Med Sci., 8, 245-246.
8. BONNETT R, WHITE RD, WINFIELD U-J AND BERENBAUM MC. (1989). Hydroporphyrins of the meso-tetra(hydroxyphenyl) porphyrin series as tumour photosensitisers. Biochem. J., 261, 277-280.
9. BONNETT R, NIZHNIK AN AND BERENBAUM MC. (1990). Porphyrin sensitisers in tumour phototherapy. Novel sensitisers of the chlorin and bacteriochlorin class with amphiphilic properties. J. Photochem. Photobiol., 6, 29-37.
10. BOWN SG. (1990). Photodynamic therapy to scientists and clinicians one world or two? J. Photochem. Photobiol. B: Biol., 6, 1-12.
11. BOWN SG, TRALAU CJ, COLERIDGE-SMITH PD, AKDEMIR D AND WEIMAN TJ. (1986). Photodynamic therapy with porphyrin and phthalocyanine sensitisation: quantitative studies in normal rat liver. Br. J. Cancer, 54, 43-52.
12. CHAN WS, MACROBERT AJ, PHILLIPS D AND HART IR. (1989). Use of a charged coupled device for imaging of intracellular phthalocyanines. Photochem. Photobiol., 50, 617-624.
13. CHAN WS, MARSHALL JF, SVENSEN R, BEDWELL J AND HART IR. (1990). Effect of sulphonation on the cell and tissue distribution of the photosensitiser aluminium phthalocyanine. Cancer Res., 50, 4533-4538.
14. CHATLANI PT, BEDWELL J, MACROBERT AJ, BARR H, BOULOS PB, KRASNER N, PHILLIPS D AND BOWN SG. (1991). Comparison of distribution and photodynamic effects of di- and tetra-sulphonated aluminium phthalocyanines in normal rat colon. Photochem and Photobiol., 53, 745-751.
15. CHATLANI PT, NUUTINEN PJO, TODA N, BARR H, MACROBERT AJ, BEDWELL J AND BOWN SG. (1992). Selective necrosis in hamster pancreatic tumours using photodynamic therapy with phthalocyanine photosensitisation. Br. J. Surg., 79, 786-790.
16. CHEVRETTON EB, BERENBAUM MC AND BONNETT R. (1992). The effect of photodynamic therapy on normal skeletal muscle in an animal model. Lasers Med Sci., 7, 103-110.
17. LI JH, CUO ZH, JIN ML, ZHAO FY, CAI WM, GAO ML, SHU MY AND ZOA J. (1990). Photodynamic therapy for the treatment of malignant tumours: an analysis of 540 cases. J. Photochem. Photobiol., 6, 149-155.
18. LOH CS, MACROBERT AJ, BEDWELL J, REGULA J, KRASNER N AND BOWN SG. (1993). Oral versus intravenous administration of 5-amino laevulinic acid for photodynamic therapy. Br. J. Cancer, 68, 41-51.
19. MESSMANN H, MLKVY P, BUONACCORSI G, DAVIES C, MACROBERT AJ AND BOWN SG. (1995). Enhancement of photodynamic therapy with 5-aminoluevulinic acid induced porphyrin photosensitisation in normal rat colon by threshold and light fractionation studies. Br. J. Cancer, 72, 589-594.
20. MLKVY P, MESSMAN H, DEBINSKI H, REGULA J, CONIO M, MACROBERT AJ, SPIGELMAN A, PHILLIPS R AND BOWN SG. (1995). Photodynamic therapy for polyps in familial adenomatous polyposis a pilot study. Eur. J. Cancer, 31A, 1160-1165.
21. NUUTINEN PJO, CHATLANI PT, BEDWELL J, MACROBERT AJ AND BOWN SG. (1991). Distribution and photodynamic effect of disulphonated aluminium phthalocyanine in the pancreas and adjacent tissues in the Syrian golden hamster. Br. J. Cancer, 64, 1108-1115.
22. PAQUETTE B, ALI H, LANGLOIS R AND VAN LIER JK. (1988). Biological activities of phthalocyanines III. Cellular distribution in V-79 Chinese hamster cells and phototoxicity of selectively sulphonated aluminium phthalocyanines. Photochem. Photobiol., 45, 215-220.
23. PENG Q, NESLAND JM, MOAN J, EVENSEN JF, KONGHSAUG M AND RIMINGTON C. (1990). Localization of fluorescent Photofrin II and aluminium phthalocyanine tetrasulphonate in the transplanted human malignant tumour LOX and normal tissues of nude mice using highly light-sensitive video intensification microscopy. Int. J. Cancer, 45, 972-979.
24. REGULA J, RAVI B, BEDWELL J. MACROBERT AJ AND BOWN SG. (1994). Photodynamic therapy using 5-aminolaevulinic acid for experimental pancreatic cancer: prolonged animal survival. Br. J. Cancer, 70, 248-254.
25. RIS HB, ALTERMATT HJ, INDERBITZI R, HESS R, WACHBUR B, STEWART JC, WANG Q, LIM CK, BONNETT R AND BERENBAUM MC. (1991). Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. Br. J. Cancer, 64, 1116-1120.
26. RIS HB, ALTERMATT HJ, NACHBUR B, STEWART CM, WANG Q, LIM CK, BONNETT R AND ALTHAUS U. (1993). Effect of drug-light interval on photodynamic therapy with meta-tetrahydroxyphenylchlorin in malignant mesothelioma. Int. J. Cancer, 53, 141-146.
27. ROBERTS WG, SMITH KM, MCCULLOUGH JL AND BERNS MW. (1989). Skin photosensitivity and photodestruction of several potential photodynamic sensitizers. Photochem. Photobiol., 49, 431-438.
28. SAVARY JF, MONNIER P, FONTOLLIET C, WAGNIERE JG, BRAICHOTTE D AND VAN DEN BERGH H. (1995). m-THPC, a second generation photosensitizer for the photodynamic therapy of early squamous cell carcinomas of the esophagus, bronchi and mouth. (abstract VI-4s/04). European Society for Photobiology 6th Congress, 3-8 September 1995, Cambridge.
29. SCHRODER T, CHEN I-W, SPERLING M, BELL Jr RH, BRACKETT K AND JOFFE SN. (1988). Hematoporphyrin derivative uptake and photodynamic therapy in pancreatic carcinoma. J. Surg. Oncol., 38, 4-9.
30. TRALAU CJ, YOUNG AR, WALKER NPJ, VERNON DI, MACROBERT AJ, BROWN SB AND BOWN SG. (1989). Mouse skin photosensitivity with dihaematoporphyrin ether (DHE) and aluminium sulphonated phthalocyanine (AlSPc): a comparative study. Photochem. Photobiol., 49, 305-312.
31. VAN DER VEEN N, VAN LEENGOED HLLM AND STAR WM. (1994). In vivo fluorescence kinetics and photodynamic therapy using 5-aminolaevulinic acid induced porphyrin: increased damage after multiple irradiations. Br. J. Cancer, 70, 867-872.
32. WEISHAUPT KR, COMER CJ AND DOUGHERTY TJ. (1976). Identification of singlet oxygen as the cytotoxic agent in the photoactivation of a murine tumour. Cancer Res., 36, 2326-2329.
33. WHEATER PR, BURKITT HG AND DANIELS VG. (1979). Gastro-intestinal system. In The Functional Histology, pp. 182-195. Churchill Livingstone: Edinburgh.