Reversal of the inhibitory effects of HIV-gp120 on CD4+ T cells by stimulation through the CD28 pathway

Clinical and Experimental Immunology

Volumn 105, Issue 2, 1996, Pages 225-230

  Faith, A ^a,c   Yssel, H ^b   O'Hehir, R E ^a   Lamb, J R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

^c SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

Author keywords

Cytokines; gp120; Inhibition; T cells; Th1

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN GP 120; INTERLEUKIN 2; INTERLEUKIN 4;

ADULT; ARTICLE; CELL LINE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0030018702     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.d01-761.x     Document Type: Article

References (27)

1. Pinching AJ. Immunological consequences of human immuno-deficiency virus infection. Rev Med Microbiol 1990; 1:83-91.
2. Capon DJ, Ward RHR. The CD4-gp120 interaction and AIDS pathogenesis. Ann Rev Immunol 1991; 9:649-78.
3. + T cell function by the HIV-envelope protein, gp120. J Immunol 1988; 141:3715-7.
4. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 1992; 175:331-40.
5. + T cells to human immunodeficiency virus-gp120 induced anergy. Immunology 1992; 76:177-84.
6. Ameglio F, Capobianchi MR, Castilletti C, Cordiali Fei P, Trento E, Dianzani F. Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells. Clin Exp Immunol 1994; 95: 455-8.
7. Chirmule N, Kalyanaraman VS, Oyaizu N, Slade HB, Pawa S. Inhibition of functional properties of tetanus antigen specific T cell clones by envelope glycoprotein gp120 of HIV. Blood 1990; 75: 152-9.
8. Hu R, Oyaizu N, Kalyanaraman VS, Pahwa S. HIV-1 gp 160 as a modifier of Th1 and Th2 cytokine response: gp160 suppresses IFN-γ and IL-2 production concomitantly with enhanced IL-4 production in vitro. Clin Immunol Immunopathol 1994; 73:245-51.
9. Tyring SK, Cauda R, Tumbarello M, Ortona L, Kennedy RC, Chanh TC, Kanda P. Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of IL-1 and TNF but depress production of IFN-α, IFN-γ, and IL-2. Viral Immunol 1991; 4:33-36.
10. Mossman TR, Cherwinski H, Bond MW, Gledin MA, Coftman RL. Two types of murine helper T cell clone. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:2348-57.
11. + individuals. J Clin Invest 1993; 91:759-65.
12. Graziosi C, Pantaleo G, Gantt KR, Fortin J-P, Demurest JF, Cohen OJ, Sekaly RP, Fauci AS. Lack of evidence for the dichotomy of Th1 and Th2 predominance in HIV-infected individuals. Science 1994; 265:248-52.
13. Maggi E, Mazzetti M, Ravina A et al. Ability of HlV to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 cells. Science 1994; 265:244-8.
14. June CH, Bluestone JA, Nadler LM, Thompson CB. The B7 and CD28 receptor families. Immunol Today 1994; 15:321-31.
15. Jenkins MK, Taylor PS, Norton SD, Urdahl KB. CD28 delivers a co-stimulatory signal involved in antigen-specific IL-2 production by human T cells. J Immunol 1991; 147:2461-6.
16. van Noesel CJM, Gruters RA, Terpstra FG, Schellekens PTA, van Lier RAW, Miedema F. Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic HIV-infected men. J Clin Invest 1990; 86:293-9.
17. Bristow RG, Douglas AR, Skehel JJ, Daniels RS. Analysis of murine antibody response to baculovirus-espressed HIV type 1 envelope glycoproteins. J Gen Virol 1994; 75:2089-95.
18. O'Hehir R, Yssel H, Verma S, de Vries JE, Spits H, Lamb JR. Clonal analysis of differential lymphokine production in peptide and superantigen induced T cell anergy. Int Immunol 1991; 3:819 26.
19. Mittler RS, Hoffmann MK. Synergism between HIV gp120 and gp120-specitic antibody in blocking T cell activation. Science 1989; 245:1380-2.
20. + cells. Eur J Immunol 1995; 25:587-95.
21. + cell production of IFN-γ and the clinical spectrum of patients at risk for and with AIDS. Arch Intern Med 1988; 148:1613.
22. Mingari MC, Moretta A, Maggi E, Pantaleo F, Gerosa F, Romagnani S, Moreta L. Frequent coexpression of cytolytic activity and lymphokine production among human T lymphocytes. Eur J Immunol 1984; 14:1066-9.
23. Hivroz C, Mazerolles F, Soula M, Fagard R, Graton S, Meloche S, Sekaly RP, Fischer A. Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p561ck in human CD4 T lymphocytes. Eur J Immunol 1993; 23:600-7.
24. Di Rienzi AM, Furlini G, Olivier R, Ferris S, Heeney J, Montagnier L. Different proliferative response of human and chimpanzee lymphocytes after contact with HIV type 1+ gp120. Eur J Immunol 1994; 24:34 40.
25. Meyaard L, Schuitmaker H, Miedema F. T cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function? Immunol Today 1993; 14:161-4.
26. Linsley PS, Greene JL, Tan P, Bradshaw J, Ledbetter JA, Anasetti C, Damle NK. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocyles. J Exp Med 1992: 176:1595 604.
27. Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995: 182:459 65.