Short-term systemic insulin-like growth factor-1 is unable to prevent cyclosporin A-induced osteopenia in the rat

Calcified Tissue International

Volumn 59, Issue 1, 1996, Pages 38-44

  Mann, G N ^c   Sass, D A ^c   Chen, H K ^b   Buchinsky, F J ^c   Bryer, H P ^a   Ma, Y F ^b   Jee, W S S ^b   Rucinski, B ^a   Epstein, S ^a  

^a ALBERT EINSTEIN MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c NONE

Author keywords

Bone; Cyclosporine; IGF I; Osteopenia; Transplantation

Indexed keywords

CALCIUM ION; CYCLOSPORIN A; GLUCOSE; OSTEOCALCIN; PARATHYROID HORMONE; RECOMBINANT SOMATOMEDIN C; VITAMIN D;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; BONE ATROPHY; BONE REMODELING; BONE TURNOVER; CONTROLLED STUDY; CORTICAL BONE; GRAFT REJECTION; IMMUNOSUPPRESSIVE TREATMENT; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; MORPHOMETRICS; NONHUMAN; ORAL DRUG ADMINISTRATION; ORGAN TRANSPLANTATION; OSTEOID; OSTEOPENIA; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TIBIA SHAFT; TRABECULAR BONE;

ANIMALS; BLOOD GLUCOSE; BONE DISEASES, METABOLIC; BONE RESORPTION; CALCIUM; CYCLOSPORINE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; OSTEOCALCIN; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY; TIBIA; WEIGHT GAIN;

EID: 0030018583     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900083     Document Type: Article

References (50)

1. Joffe I, Katz I, Sehgal S, et al. (1993) Lack of change of cancellous bone volume with short-term use of the new immunosuppresent rapamycin in rats. Calcif Tissue Int 53:45-52
2. Keown PA, Stiller CR (1987) Cyclosporine: a double-edged sword. Hosp Prac 22:207-220
3. Movsowitz C, Epstein S, Ismail F, Fallon M, Thomas S (1989) Cyclosporin A in the oophorectomized rat: unexpected severe bone resorption. J Bone Miner Res 4:393-398
4. Movsowitz C, Epstein S, Fallon M, Ismail F, Thomas S (1988) Cyclosporin A in vivo produces severe osteopenia in the rat: effect of dose and duration of administration. Endocrinology 123:2571-2577
5. Aubia J, Masramon J, Serrano S, Lloveras J, Marinoso LL (1988) Bone histology in renal transplant patients receiving cyclosoporin. Lancet 1:1048-1049
6. Shane E, Rivas MDC, Silverberg SJ, Kim TS, Staron RB, Bilezikian JP (1993) Osteoporosis after cardiac transplantation. Am J Med 94:257-264
7. Sambrook PN, Kelly PJ, Fontana D, et al. (1994) Mechanisms of rapid bone loss following cardiac transplantation. Osteoporosis Int 4:273-276
8. Froesch ER, Schmid C, Schwander J, Zapf J (1985) Actions of insulin-like growth factors. Ann Rev Physiol 47:443
9. Schlechter NL, Russell SM, Spencer EM, Nicoll CS (1986) Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc Natl Acad Soc USA 83: 7932
10. Watson P, Lazowski D, Han V, Fraher L, Steer B, Hodsman A (1995) Parathyroid hormone restores bone mass and enhances osteoblast insulin-like growth factor 1 gene expression in ovariectomized rats. Bone 16(3):357-365
11. Canalis E, Centrella M, Burch W, McCarthy TL (1989) Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures. J Clin Invest 83:60-65
12. McCarthy TL, Centrella M, Raisz LG, Canalis E (1991) Prostaglandin E2 stimulates insulin-like growth factor 1 synthesis in osteoblast-enriched cultures from fetal rat bone. Endocrinology 128:2895-2900
13. Canalis E, Pash J, Gabbitas B, Rydziel S, Varghese S (1993) Growth factors regulate the synthesis of insulin-like growth factor-1 in bone cell cultures. Endocrinology 133:33-38
14. McCarthy TL, Centrella M, Canalis E (1989) Regulatory effects of insulin-like growth factors 1 and 11 on bone collagen synthesis in rat calvarial cultures. Endocrinology 124:301-309
15. Hock JM, Centrella M, Canalis E (1988) Insulin-like growth factor-1 (IGF-1) has independent effects on bone matrix formation and cell replication. Endocrinology 122:254-260
16. Mochizuki H, Hakeda Y, Wakatsuki N, et al. (1992) Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology 131:1075-1080
17. Canalis E (1994) (editorial) Skeletal growth factors and aging. J Clin Endocrinol Metab 78(5):1009-1010
18. Tobias JH, Chow JWM, Chambers TJ (1992) Opposite effects of insulin-like growth factor-1 on the formation of trabecular and cortical bone in adult female rats. Endocrinology 131: 2387-2392
19. Ibbotson KJ, Orcutt CM, D'Souza SM, et al. (1992) Contrasting effects of parathyroid hormone and insulin-like growth factor 1 in an aged ovariectomized rat model of postmenopausal osteoporosis. J Bone Miner Res 7:425-432
20. Spencer EM, Liu CC, Si ECC, Howard GA (1991) In vivo actions of insulin-like growth factor-1 (IGF-1) on bone formation and resorption in rats. Bone 12:21-26
21. Kalu DN Liu CC, Salerno E, et al. (1991) Insulin-like growth factor-1 partially prevents ovariectomy-induced bone loss: a comparative study with human parathyroid hormone (1-38). J Bone Miner Res 6:S221
22. Mueller K, Cortesi R (1991) Insulin-like growth factor-1 increases trabecular bone mass on the ovariectomised rat. J Bone Miner Res 6:S221
23. Shapiro JR, Rachis R, Bellantoni M, Harman SM, Blackman MR (1993) The effect of IGF-1 on skeletal turnover in postmenopausal women. J Bone Miner Res 8:S327
24. Ebeling PR, Jones JD, O'Fallon WM, Janes CH, Riggs BL (1993) Short-term effects of recombinant human insulin-like growth factor I on bone turnover in normal women. J Clin Endocrinol Metab 77(5):1384-1387
25. Beschorner WE, Divic J, Pulido H, Yao X, Kenworthy P, Bruce G (1991) Enhancement of thymic recovery after cyclosporine by recombinant human growth hormone and insulin-like growth factor-1. Transplantation 52:879-884
26. Price PA, Parthemore JG, Deftos LJ (1980) New biochemical marker for bone metabolism: measurement by radioimmunoassay of bone gla protein in the plasma of normal subjects and patients with bone disease. J Clin Invest 66:878
27. Rucinski B, Mann GN, Epstein S (1995) A new rapid and reproducible homologous immunoradiometric assay for amino-terminal parathyroid hormone in the rat. Calcif Tissue Int 56:83-87
28. Reinhardt TA, Horst RL, Orf JW, Hollis BW (1986) A microassay for 1,25-dihydroxyvitamin D not requiring high performance liquid chromatography: application to a clinical studies. J Clin Endocrinol Metabl 58:91-98
29. Jee WSS, Inoue J, Jee KW, Haba T (1983) Histomorphometric assay of the growing long bone. In: Takahashi H (ed) Handbook of bone morphology. Nishimura Co., Ltd., Niigata City, pp 101-122
30. Li XJ, Jee WSS, Ke HZ, Mori S, Akamine T (1992) Age-related changes of cancellous and cortical bone histomorphometry in female Sprague-Dawley rats. Cells Materials (suppl)1:25-35
31. Jee WSS, Ke HZ, Li XJ, Long-term anabolic effect of prostaglandin E2 on tibial diaphyseal bone in male rats. Bone Miner (1991)15:33-55
32. Parfitt AM, Drezner MK, Glorieux FH, et al. (1987) Bone histomorphometry: standardization of nomenclature, symbols and units. Report of the ASBMR Histomorphometry Committee. J Bone Miner Res 2:595-610
33. Brommage R, Millerman E, Sweett E, DeLeon E, Adams S, Bagi CM (1993) Treatment with the rhIGF-1/IGFBP-3 complex increases cortical bone and lean body mass in ovariectomized rats. J Bone Miner Res (supp 1)8:S134
34. Clemmons DR, Smith-Banks A, Underwood LE (1992) Reversal of diet-induced catabolism by infusion of recombinant insulin-like growth factor-1 in humans. J Clin Endocrinol Metab 75(1):234-238
35. Guler HP, Zapf J, Scheiwiller E, Froesch ER (1988) Recombinant human insulin-like growth factor-1 stimulates growth and has distinctive efffects on organ size in hypophysectomized rats. Proc Natl Acad Sci USA 85:4889-4893
36. Hizuka N, Takano K, Shizume K (1986) IGF-1 stimulates growth in normal growing rats. Eur J of Pnarmacol 125:143-146
37. Romero DF, Buchinsky FJ, Rucinski B, et al. (1995) Rapamycin: a bone-sparing immunosuppressant? J Bone Miner Res 10(5):760-768
38. Helmchen U, Schmidt WE, Siegel E, Creutzfeldt W (1984) Morphological and functional changes in pancreatic B cells in cyclosporin A-treated rats. Diabetologia 27:416-418
39. Stein B, Halloran BP, Reinhardt G, et al. (1991) Cyclosporin-A increases synthesis of 1,25 dihydroxyvitamin D3 in the rat and mouse. Endocrinology 128:1369-1373
40. Schlosberg M, Movsowitz C, Epstein S, Fallon MD, Thomas S (1989) The effect of cyclosporin A administration and its withdrawal on bone mineral metabolism in the rat. Endocrinology 124:2179-2184
41. Jacobs TW, Katz IA, Joffe II, Stein B, Takizawa M, Epstein S (1991) The effect of FK 506, cyclosporine A, and cyclosporine G on serum 1,25 dihydroxyvitamin D3 levels. Trans Proc 23(6):3188-3189
42. 3. Biochemistry 27:8521-8526
43. Ismail F, Epstein S, Fallon MD, Thomas SB, Reinhardt TA (1988) Serum bone gla protein and the vitamin D endocrine system in the oophorectomized rat. Endocrinology 122:624-630
44. Jacobs TW, Epstein S (1992) Current status of serum-derived bone proteins. In: Davidovitch Z (ed) The biological mechanisms of tooth movement and craniofacial adaptation. Ohio State University College of Dentistry, Columbus, 149-158
45. Klein L, Lemel MS, Wolfe MS, Shaffer J (1994) CsA does not affect the absolute rate of cortical bone resorption at the organ level in the growing rat. Calcif Tissue Int 55:295-301
46. Bagi CM, Brommage R, Deleon L, Adams S, Rosen D, Sommer A (1994) Benefit of systemically administered rhIGF-1/ GFBP-3 on cancellous bone in ovariectomized rats. J Bone Miner Res 9(8):1301-1312
47. Canalis E (1993) Systemic and local factors and the maintenance of bone quality. Calcif Tissue Int 53(supp 1):S90-S93
48. Bagi C, Van Der Meulen M, Brommage R, Rosen D, Sommer A (1995) The effect of systemically administered rhIGF-1/ IGFBP-3 complex on cortical bone strength and structure in ovariectomized rats. Bone 16(5):559-565
49. Dempster DW, Cosman F, Parisien M, Shen V, Lindsay R (1993) Anabolic actions of parathyroid hormone on bone. Endoer Rev 14(6):690-709
50. Kupfer SR, Underwood LE, Baxter RC, Gemmons DR (1993) Enhancement of the anabolic effects of GH and IGF-1 by use of both agents simultaneously. J Clin Invest 91:391-396