Phosphatidylethanolamine methylation and hepatoma cell growth

Anticancer Research

Volumn 16, Issue 3 B, 1996, Pages 1413-1416

  Vance, Dennis E ^a   Houweling, Martin ^a   Lee, Mark ^a   Cui, Zheng ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cancer; CTP: phosphocholine cytidylyltransferase; Hepatoma cells; Phosphatidylcholine; Phosphatidylethanolamine; Phosphatidylethanolamine N methyltransferase; Tumor suppressor

Indexed keywords

CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE;

ANIMAL CELL; CANCER GROWTH; CELL DIVISION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME LOCALIZATION; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER MITOCHONDRION; METHYLATION; MITOCHONDRIAL MEMBRANE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL DIVISION; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE; LIVER NEOPLASMS, EXPERIMENTAL; METHYLATION; METHYLTRANSFERASES; NUCLEOTIDYLTRANSFERASES; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; PHOSPHATIDYLETHANOLAMINES; RATS;

EID: 0030018478     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (17)

1. Vance DE: Glycerolipid biosynthesis in eukaryotes. In: Biochemistry of Lipids, Lipoproteins and Membranes (Vance DE and Vance JE, eds). Amsterdam, Elsevier, 1996, In Press.
2. Bremer J and Greenberg DM: Methyl transfering enzyme system of microsomes in the biosynthesis of lecithin (phosphatidylcholine). Biochim Biophys Acta 46: 205-216, 1961.
3. Vance DE: Phosphatidylcholine Metabolism: masochistic enzymology, metabolic regulation, and lipoprotein assembly. Biochem Cell Biol 68: 1151-1165, 1990.
4. Ridgway ND and Vance DE: Purification of phosphatidylethanolamine N methyltransferase from rat liver. J Biol Chem 262: 17231-17239, 1987.
5. Cui Z, Vance JE, Chen MH, Voelker DR and Vance DE: Cloning and expression of a novel phosphatidylethanolamine N-methyltransferase. J Biol Chem 268: 16655-16663, 1993.
6. Vance JE: Phospholipid synthesis in a membrane fraction associated with mitochondria. J Biol Chem 265: 7248-7256, 1990.
7. Rusinol AE, Cui Z, Chen MH, and Vance JE: A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins. J Biol Chem 269: 27494-27502, 1994.
8. Cui Z, Houweling M, and Vance DE: Suppression of rat hepatoma cell growth by expression of phosphatidylethanolamine N-methyltransferase-2. J Biol Chem 269: 24531 -24533, 1994.
9. Chiang PK and Cantoni GL: Perturbation of Biochemical transmethylations by 3-deazaadenosine In Vivo Biochem Pharm 28: 1897-1902, 1979.
10. Walkey CJ, Kalmer GB and Cornell RB: Overexpression of rat liver CTP:phosphocholine cytidylyltransferase accelerates phosphatidylcholine synthesis and degradation. J Biol Chem 269: 5742-5749, 1994.
11. Cui Z, Houweling M, and Vance DE: Expression of phosphatidylethanolamine N-methyltransferase-2 in McArdle-RH7777 hepatoma cells inhibits the CDP-choline pathway for phosphatidylcholine biosynthesis via decreased gene expression of CTP:phosphocholine cytidylyltransferase. Biochem J 312: 939-945, 1995.
12. Higgins GM and Anderson RM: Experimental pahtology of the liver: I Restoration of the liver of the white rat following partial surgical removal. Arch Pathol. 12: 186-202.
13. Houweling M, Tijhurg LBM, Jamil H, Vance DE, Nyathi CB, Vaartjes WJ and Van Golde LMG: Phosphatidylcholine metabolism in rat liver after partial hepatectomy. Biochem J 278: 347-351, 1991.
14. Houweling M, Tijburg LBM, Vaartjes WJ, Batenburg JJ, Kalmar GB, Cornell RB and Van Golde LMG: Evidence that CTP: cholinephosphate cytidylyltransferase is regulated at a pretranslational level in rat liver after partial hepatectomy. Eur J Biochem 214: 927-933, 1993.
15. Tessitore L, Perletti GP, Sesca E, Pani P, Dianzani MU and Piccinini F: Protein kinase C isozyme pattern in liver hyperplasia. Biochem Biophys Res Commun 205: 208-214, 1994.
16. Eagle H: The minimum vitamin requirements of the L and HeLa cells in tissue culture, the production of specific vitamin deficiencies, and their cure. J Exp Med 102: 595-600, 1955.
17. Terce F, Brun H, and Vance DE: Requirement of phosphatidylcholine for normal progression through the cell cycle in C3H/10T1/2 fibroblasts. J Lipid Res 35: 2130-2142, 1994.