Comparison of the pharmacokinetics of dolasetron and its major active metabolite, reduced dolasetron, in dog

Journal of Pharmaceutical Sciences

Volumn 85, Issue 7, 1996, Pages 685-689

  Dow, J ^a   Di Francesco, G F ^a   Berg, C ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

(2ALPHA,6ALPHA,8ALPHA,9ABETA)OCTAHYDRO 3 HYDROXY 2,6 METHANO 2H QUINOLIZIN 8 YL 1H INDOLE 3 CARBOXYLIC ACID; DOLASETRON MESILATE; DRUG METABOLITE; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; VOMITING;

EID: 0030017746     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js960041m     Document Type: Article

References (15)

1. Gittos, M. W.; Fatmi, M. Actual. Chim. Ther. 1989, 16, 187-189.
2. Miller, R. C.; Galvan, M.; Gittos, M. W.; van Giersbergen, P. L. M.; Moser, P. C.; Fozard, J. R. Drug Dev. Res. 1993, 28, 87-93.
3. Aapro, M. S. Drugs 1991, 42, 551-568.
4. Dow, J.; Berg, C. Chirality 1995, 7, 342-348.
5. Boeijinga, P. H.; Galvan, M.; Baron, B. M.; Dudley, M. W.; Siegel, B. W.; Slone, A. L. Eur. J. Pharmacol. 1992, 219, 9-13.
6. Boxenbaum, H.; Gillespie, T.; Heck, K.; Hahne, W. Biopharm. Drug Dispos. 1992, 13, 693-701.
7. Boxenbaum, H.; Gillespie, T.; Heck, K.; Hahne, W. Biopharm. Drug Dispos. 1993, 14, 131-141.
8. Huebert, N.; Schwartz, J.-J.; Zeidler, L.; Schwach, V.; Haegele, K. D. J. Chromatogr. B, in press.
9. Gomeni, C.; Gomeni, R. Comput. Biomed. Res. 1978, 11, 345-361.
10. Kaplan, S. A.; Jack, M. L.; Cotler, S.; Alexander, K. J. Pharmacokinet. Biopharm. 1983, 1, 201-216.
11. Artursson, P. J. Pharm. Sci. 1990, 79, 476-482.
12. Artursson, P.; Karlsson, J. Biochem. Biophys. Res. Commun. 1991, 175, 880-885.
13. Felsted, R. L.; Bachur, N. R. Drug Metab. Rev. 1980, 11, 1-60.
14. Fogh, J.; Fogh, J. M.; Orfeo, T. J. Natl. Cancer Inst. 1977, 59, 221-226.
15. Grote, T.; Modiano, M.; Gandara, D.; Cocquyt, V.; Hahne, W. Eur. J. Cancer 1995, 31A (Suppl. 5), S255.