Characterization of dysfunctional protein S-Tokushima (K155 → E) in relation to the molecular interactions required for the regulation of blood coagulation

Polish Journal of Pharmacology

Volumn 48, Issue 2, 1996, Pages 221-223

  Hayashi, Tatsuya ^a   Nishioka, Junji ^a   Suzuki, Koji ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

Factor Va; Factor Xa; Molecular interaction; Protein C; Protein S

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; MUTANT PROTEIN; PHOSPHOLIPID; PROTEIN S;

BLOOD CLOTTING; CELL STRAIN BHK; CONFERENCE PAPER; CONTROLLED STUDY; HETEROZYGOSITY; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; REGULATORY MECHANISM; VEIN THROMBOSIS;

ANIMALS; BLOOD COAGULATION; FACTOR XA; HUMANS; PROTEIN C; PROTEIN S; RABBITS; RECOMBINANT PROTEINS;

EID: 0030017648     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (5)

1. Hackeng T. M., van't Veer C. et al.: Human protein S inhibits prothrombinase complex activity on. endothelial cells and platelets via direct interactions with factor Va and Xa. J. Biol. Chem., 1994, 269, 21051-21058.
2. Hayashi T., Nishioka J. et al.: Protein S Tokushima: Abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S. Blood, 1994, 83, 683-690.
3. Heeb M. J., Masters R. M. et al.: Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C. J. Biol. Chem., 1993, 268, 2872-2877.
4. Schwartz H. P., Heeb M. J. et al.: Familial protein S deficiency with a variant protein S molecule in plasma and platelets. Blood, 1989, 74, 213-221.
5. Walker F. J.: Regulation of activated protein C by protein S. The role of phospholipid in factor Va inactivation. J. Biol. Chem., 1981, 256, 11128-11131.