메뉴 건너뛰기




Volumn 48, Issue 2, 1996, Pages 129-136

Variability in the effects of 5-HT-related compounds in experimental models of anxiety: Evidence for multiple mechanisms of 5-HT in anxiety or never ending story?

(1)  Griebel, Guy a  

a SANOFI   (France)

Author keywords

5 HT (serotonin); Animal models; Anxiety; Review

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; ANXIOLYTIC AGENT; BEMESETRON; BUSPIRONE; FLUOXETINE; GEPIRONE; GRANISETRON; ONDANSETRON; RECEPTOR SUBTYPE; RICASETRON; RITANSERIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1C RECEPTOR; SEROTONIN 2A AGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN RECEPTOR AFFECTING AGENT; SEROTONIN UPTAKE INHIBITOR; TROPISETRON; ZACOPRIDE;

EID: 0030017587     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (29)

References (40)
  • 1
    • 8944250154 scopus 로고
    • Neurochemical correlates of behavior. II. Correlation of brain monoamine oxidase activity with behavioural changes after iproniazid and 5-hydroxytryptophan administration
    • Aprison M. H., Ferster C. B.: Neurochemical correlates of behavior. II. Correlation of brain monoamine oxidase activity with behavioural changes after iproniazid and 5-hydroxytryptophan administration. J. Neurochem., 1961, 6, 350-357.
    • (1961) J. Neurochem. , vol.6 , pp. 350-357
    • Aprison, M.H.1    Ferster, C.B.2
  • 3
    • 0027208571 scopus 로고
    • 5-HT receptors as targets for the development of novel anxiolytic drugs: Models, mechanisms and future directions
    • Barrett J. E., Vanover K. E.: 5-HT receptors as targets for the development of novel anxiolytic drugs: models, mechanisms and future directions. Psychopharmacology, 1993, 112, 1-12.
    • (1993) Psychopharmacology , vol.112 , pp. 1-12
    • Barrett, J.E.1    Vanover, K.E.2
  • 4
    • 0027443437 scopus 로고
    • A placebo-controlled double-blind multicenter trial of two doses of ipsapirone versus diazepam in generalized anxiety disorder
    • Boyer W. F., Feighner J. P.: A placebo-controlled double-blind multicenter trial of two doses of ipsapirone versus diazepam in generalized anxiety disorder. Int. Clin. Psychopharmacol., 1993, 8, 173-176.
    • (1993) Int. Clin. Psychopharmacol. , vol.8 , pp. 173-176
    • Boyer, W.F.1    Feighner, J.P.2
  • 5
    • 0023160536 scopus 로고
    • Serotonin S2 receptors blockage and generalized anxiety disorders. A double-blind study on ritanserin and lorazepam
    • Bressa G. M., Marini S., Gregori S.: Serotonin S2 receptors blockage and generalized anxiety disorders. A double-blind study on ritanserin and lorazepam. Int. J. Clin. Pharmacol. Res., 1987, 7, 111-119.
    • (1987) Int. J. Clin. Pharmacol. Res. , vol.7 , pp. 111-119
    • Bressa, G.M.1    Marini, S.2    Gregori, S.3
  • 6
    • 0022183592 scopus 로고
    • The influence of ritanserin, a serotonin antagonist, in anxiety disorders: A double-blind placebo-controlled study versus lorazepam
    • Ceulemans D. L., Hoppenbrouwers M. L., Gelders Y. G., Reyntjens A. J.: The influence of ritanserin, a serotonin antagonist, in anxiety disorders: a double-blind placebo-controlled study versus lorazepam. Pharmacopsychiatry, 1985, 18, 303-305.
    • (1985) Pharmacopsychiatry , vol.18 , pp. 303-305
    • Ceulemans, D.L.1    Hoppenbrouwers, M.L.2    Gelders, Y.G.3    Reyntjens, A.J.4
  • 7
    • 0003097463 scopus 로고
    • Effects of behaviorally active drugs in a conflict-punishment procedure in rats
    • Eds. Garattini S., Mussini E., Randall L. O., Raven Press, New York
    • Cook L., Davidson A. B.: Effects of behaviorally active drugs in a conflict-punishment procedure in rats. In: The Benzodiazepines. Eds. Garattini S., Mussini E., Randall L. O., Raven Press, New York, 1973, 379-404.
    • (1973) The Benzodiazepines , pp. 379-404
    • Cook, L.1    Davidson, A.B.2
  • 10
    • 0027749595 scopus 로고
    • A double-blind, placebo-controlled study comparing the efficacy and safety of ipsapirone versus lorazepam in patients with generalized anxiety disorder: A prospective multicenter trial
    • Cutler N. R., Sramek J. J., Keppel Hesselink J. M., Krol A., Roeschen J., Rickels K., Schweizer E.: A double-blind, placebo-controlled study comparing the efficacy and safety of ipsapirone versus lorazepam in patients with generalized anxiety disorder: a prospective multicenter trial. J. Clin. Psychopharmacol., 1993, 13, 429-437.
    • (1993) J. Clin. Psychopharmacol. , vol.13 , pp. 429-437
    • Cutler, N.R.1    Sramek, J.J.2    Keppel Hesselink, J.M.3    Krol, A.4    Roeschen, J.5    Rickels, K.6    Schweizer, E.7
  • 11
    • 0027376598 scopus 로고
    • The safety and efficacy of ipsapirone vs. lorazepam in outpatients with generalized anxiety disorder (GAD): Single site findings from a multicenter trial
    • Cutler N. R., Sramek J. J., Wardle T. S., Hesselink J. M., Roeschen J. K.: The safety and efficacy of ipsapirone vs. lorazepam in outpatients with generalized anxiety disorder (GAD): single site findings from a multicenter trial. Psychopharmacol. Bull., 1993, 29, 303-308.
    • (1993) Psychopharmacol. Bull. , vol.29 , pp. 303-308
    • Cutler, N.R.1    Sramek, J.J.2    Wardle, T.S.3    Hesselink, J.M.4    Roeschen, J.K.5
  • 12
    • 0025282360 scopus 로고
    • Serotonin function in panic disorder: A double blind placebo controlled study with fluvoxamine and ritanserin
    • den Boer J. A., Westenberg H. G.: Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin. Psychopharmacology, 1990, 102, 85-94.
    • (1990) Psychopharmacology , vol.102 , pp. 85-94
    • Den Boer, J.A.1    Westenberg, H.G.2
  • 13
    • 0022454051 scopus 로고
    • Recent developments in 5HT-related pharmacology of animal models of anxiety
    • Gardner C. R.: Recent developments in 5HT-related pharmacology of animal models of anxiety. Pharmacol. Biochem. Behav., 1986, 24, 1479-1485.
    • (1986) Pharmacol. Biochem. Behav. , vol.24 , pp. 1479-1485
    • Gardner, C.R.1
  • 14
    • 0027225830 scopus 로고
    • 3 receptor antagonists: A critical update on therapeutic potential
    • 3 receptor antagonists: a critical update on therapeutic potential. Trends Pharmacol. Sci., 1993, 14, 265-270.
    • (1993) Trends Pharmacol. Sci. , vol.14 , pp. 265-270
    • Greenshaw, A.J.1
  • 15
    • 0028986825 scopus 로고
    • 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research
    • Griebel G.: 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol. Ther., 1995, 65, 319-395.
    • (1995) Pharmacol. Ther. , vol.65 , pp. 319-395
    • Griebel, G.1
  • 16
    • 0027314962 scopus 로고
    • Some critical determinants of the behaviour of rats in the elevated plus-maze
    • Griebel G., Moreau J.-L., Jenck F., Martin J. R., Misslin R.: Some critical determinants of the behaviour of rats in the elevated plus-maze. Behav. Process., 1993, 29, 37-47.
    • (1993) Behav. Process. , vol.29 , pp. 37-47
    • Griebel, G.1    Moreau, J.-L.2    Jenck, F.3    Martin, J.R.4    Misslin, R.5
  • 17
    • 0024147764 scopus 로고
    • Serotonin antagonism in panic disorder: An open trial with ritanserin
    • Griez E., Pols H., Lousberg H.: Serotonin antagonism in panic disorder: an open trial with ritanserin. Acta Psychiat. Belg., 1988, 88, 372-377.
    • (1988) Acta Psychiat. Belg. , vol.88 , pp. 372-377
    • Griez, E.1    Pols, H.2    Lousberg, H.3
  • 18
    • 0028935942 scopus 로고
    • 5-Hydroxytryptamine pathways in anxiety and its treatment
    • Handley S. L.: 5-Hydroxytryptamine pathways in anxiety and its treatment. Pharmacol. Ther., 1995, 66, 103-148.
    • (1995) Pharmacol. Ther. , vol.66 , pp. 103-148
    • Handley, S.L.1
  • 19
    • 0027292902 scopus 로고
    • An assessment of the elevated X-maze for studying anxiety and anxiety-modulating drugs
    • Handley S. L., McBlane J. W.: An assessment of the elevated X-maze for studying anxiety and anxiety-modulating drugs. J. Pharmacol. Toxicol. Method., 1993, 29, 129-138.
    • (1993) J. Pharmacol. Toxicol. Method. , vol.29 , pp. 129-138
    • Handley, S.L.1    McBlane, J.W.2
  • 20
    • 0027250855 scopus 로고
    • 5-HT drugs in animal models of anxiety
    • Handley S. L., McBlane J. W.: 5-HT drugs in animal models of anxiety. Psychopharmacology, 1993, 112, 13-20.
    • (1993) Psychopharmacology , vol.112 , pp. 13-20
    • Handley, S.L.1    McBlane, J.W.2
  • 21
    • 0027479912 scopus 로고
    • Serotonin mechanisms in animal models of anxiety
    • Handley S. L., McBlane J. W.: Serotonin mechanisms in animal models of anxiety. Braz. J. Med. Biol. Res., 1993, 26, 1-13.
    • (1993) Braz. J. Med. Biol. Res. , vol.26 , pp. 1-13
    • Handley, S.L.1    McBlane, J.W.2
  • 22
    • 0027729920 scopus 로고
    • Multiple serotonin mechanisms in animal models of anxiety: Environmental, emotional and cognitive factors
    • Handley S. L., McBlane J. W., Critchley M. A., Njung'e K.: Multiple serotonin mechanisms in animal models of anxiety: environmental, emotional and cognitive factors. Behav. Brain Res., 1993, 58, 203-210.
    • (1993) Behav. Brain Res. , vol.58 , pp. 203-210
    • Handley, S.L.1    McBlane, J.W.2    Critchley, M.A.3    Njung'e, K.4
  • 23
    • 0024507731 scopus 로고
    • Molecular biology of 5-HT receptors
    • Hartig P. R.: Molecular biology of 5-HT receptors. Trends Pharmacol. Sci., 1989, 10, 64-69.
    • (1989) Trends Pharmacol. Sci. , vol.10 , pp. 64-69
    • Hartig, P.R.1
  • 24
    • 0023895447 scopus 로고
    • 1 recognition sites
    • 1 recognition sites. J. Recept. Res., 1988, 8, 59-81.
    • (1988) J. Recept. Res. , vol.8 , pp. 59-81
    • Hoyer, D.1
  • 27
    • 0027209603 scopus 로고
    • Effects on open-field behavior of diazepam and buspirone alone and in combination with chronic caffeine
    • Hughes R. N.: Effects on open-field behavior of diazepam and buspirone alone and in combination with chronic caffeine. Life Sci., 1993, 53, 1217-1225.
    • (1993) Life Sci. , vol.53 , pp. 1217-1225
    • Hughes, R.N.1
  • 28
    • 0021706422 scopus 로고
    • 5-HT and anxiety
    • Iversen S. D.: 5-HT and anxiety. Neuropharmacology, 1984, 23, 1553-1560.
    • (1984) Neuropharmacology , vol.23 , pp. 1553-1560
    • Iversen, S.D.1
  • 29
    • 0027205397 scopus 로고
    • A randomized double-blind placebo-controlled study of tropisetron in the treatment of outpatients with generalized anxiety disorder
    • Lecrubier Y., Puech A. J., Azcona A., Bailey P. E., Lataste X.: A randomized double-blind placebo-controlled study of tropisetron in the treatment of outpatients with generalized anxiety disorder. Psychopharmacology, 1993, 112, 129-133.
    • (1993) Psychopharmacology , vol.112 , pp. 129-133
    • Lecrubier, Y.1    Puech, A.J.2    Azcona, A.3    Bailey, P.E.4    Lataste, X.5
  • 30
    • 0027943744 scopus 로고
    • Effects of two Stressors on behaviour in the elevated X-maze: Preliminary investigation of their interaction with 8-OH-DPAT
    • McBlane J. W., Handley S. L.: Effects of two Stressors on behaviour in the elevated X-maze: preliminary investigation of their interaction with 8-OH-DPAT. Psychopharmacology, 1994, 116, 173-182.
    • (1994) Psychopharmacology , vol.116 , pp. 173-182
    • McBlane, J.W.1    Handley, S.L.2
  • 31
    • 0344467192 scopus 로고
    • Anxiolytic effects of drugs acting on 5-HT receptor subtypes
    • Eds. Vanhoutte P. M., Saxena P. R., Paoletti R., Brunello N., Jackson A. S., Kluwer Academic Publishers, Dordrecht
    • Murphy D. L., Brooks A., Aulakh C., Pigott T. A.: Anxiolytic effects of drugs acting on 5-HT receptor subtypes. In: Serotonin, from Cell Biology to Pharmacology and Therapeutics. Eds. Vanhoutte P. M., Saxena P. R., Paoletti R., Brunello N., Jackson A. S., Kluwer Academic Publishers, Dordrecht, 1993, 223-230.
    • (1993) Serotonin, from Cell Biology to Pharmacology and Therapeutics , pp. 223-230
    • Murphy, D.L.1    Brooks, A.2    Aulakh, C.3    Pigott, T.A.4
  • 33
    • 0028672948 scopus 로고
    • Overlap of buspirone with lorazepam, diazepam and bromazepam in patients with generalized anxiety disorder: Findings from a controlled, multicentre, double-blind study
    • Sacchetti E., Zerbini O., Banfi F., Tansella M.: Overlap of buspirone with lorazepam, diazepam and bromazepam in patients with generalized anxiety disorder: findings from a controlled, multicentre, double-blind study. Hum. Psychopharmacol. Clin. Exp., 1994, 9, 409-422.
    • (1994) Hum. Psychopharmacol. Clin. Exp. , vol.9 , pp. 409-422
    • Sacchetti, E.1    Zerbini, O.2    Banfi, F.3    Tansella, M.4
  • 34
    • 0027277135 scopus 로고
    • 1A receptor ligands in animal models of anxiety, impulsivity and depression: Multiple mechanisms of action?
    • 1A receptor ligands in animal models of anxiety, impulsivity and depression: multiple mechanisms of action? Prog. NeuroPsychopharmacol. Biol. Psych., 1993, 17, 87-104.
    • (1993) Prog. NeuroPsychopharmacol. Biol. Psych. , vol.17 , pp. 87-104
    • Schreiber, R.1    De Vry, J.2
  • 39
    • 0001083653 scopus 로고
    • Serotonin in anxiety related disorders
    • Eds. Vanhoutte P. M., Saxena P. R., Paoletti R., Brunello N., Jackson A. S., Kluwer Academic Publishers, Dordrecht
    • Westenberg H. G. M., Den Boer J. A.: Serotonin in anxiety related disorders. In: Serotonin, from Cell Biology to Pharmacology and Therapeutics. Eds. Vanhoutte P. M., Saxena P. R., Paoletti R., Brunello N., Jackson A. S., Kluwer Academic Publishers, Dordrecht, 1993, 249-254.
    • (1993) Serotonin, from Cell Biology to Pharmacology and Therapeutics , pp. 249-254
    • Westenberg, H.G.M.1    Den Boer, J.A.2
  • 40
    • 0001770262 scopus 로고
    • Serotonergic basis of panic disorder
    • Oxford University Press, Oxford
    • Westenberg H. G. M., Den Boer J. A.: Serotonergic basis of panic disorder. In: Psychopharmacology of Panic, Oxford University Press, Oxford, 1993, 91-109.
    • (1993) Psychopharmacology of Panic , pp. 91-109
    • Westenberg, H.G.M.1    Den Boer, J.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.