Diastereoselective (ethoxycarbonyl)difluoromethylation of chiral imide enolates mediated by triethylborane

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 7, 1996, Pages 1314-1317

  Iseki, Katsuhiko ^a   Asada, Daisuke ^a   Takahashi, Mie ^a   Nagai, Takabumi ^a   Kobayashi, Yoshiro ^a  

^a DAIKIN INDUSTRIES LTD   (Japan)

Author keywords

(ethoxycarbonyl)difluoromethylation; asymmetric synthesis; chiral fluorinated compound; ethyl difluoroiodoacetate; N acyloxazolidinone; triethylborane

Indexed keywords

ACETIC ACID DERIVATIVE; BORANE DERIVATIVE; IMIDE; LITHIUM DERIVATIVE; OXAZOLIDINONE DERIVATIVE;

ARTICLE; CHIRALITY; DIASTEREOISOMER; DRUG STRUCTURE; METHYLATION; REACTION ANALYSIS;

EID: 0030017449     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.1314     Document Type: Article

References (23)

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23. The (ethoxycarbonyl)difluoromethylation may possibly not require the generation of stoichiometric amounts of ethyl radical, since a catalytic amount of oxygen in argon, solvents and reagents can activate only a small amount of triethylborane.