Comparison of phenobarbitone, phenytoin with sodium valproate: Randomized, double-blind study

Indian Pediatrics

Volumn 33, Issue 7, 1996, Pages 549-555

  Thilothammal, N ^a,b   Banu, K ^a   Ratnam, R S ^a  

^a INSTITUTE OF CHILD HEALTH AND HOSPITAL FOR CHILDREN   (India)

^b NONE   (India)

Author keywords

anticonvulsants; convulsions; phenobarbitone; phenytoin; sodium valproate

Indexed keywords

PHENOBARBITAL; PHENYTOIN; PLACEBO; VALPROIC ACID;

ARTICLE; ATAXIA; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FOLLOW UP; GRAND MAL EPILEPSY; HUMAN; HYPERACTIVITY; MAJOR CLINICAL STUDY; MALE; NYSTAGMUS; ORAL DRUG ADMINISTRATION; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; RASH; RECURRENT DISEASE; SKIN ALLERGY;

CHILD; CHILD, PRESCHOOL; EPILEPSY, TONIC-CLONIC; FEMALE; HUMANS; PHENOBARBITAL; PHENYTOIN; RECURRENCE; VALPROIC ACID;

EID: 0030017195     PISSN: 00196061     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Menkes JH. Textbook of Child Neurology, 4th edn. Philadelphia, Lea and Febiger, 1990, pp 602-674.
2. Gomez MR, Klass DW. Epilepsies of infancy and childhood. Ann Neurol 1983, 13: 113-124.
3. Leviton A, Cowan LD. Epidemiology of Seizure disorders in children. Neuroepidemiology 1982, 1: 40-83.
4. O' Leary DS, Seidenberg M, Berent S, Boll TJ. The effects of age of onset of tonicclonic seizures on neuropsychological performance in children. Epilepsia 1981, 22: 197-203.
5. Dodrill CB. Correlates of generalized tonic-clonic seizures with intellectual, neuropsychological, emotional and social function in patients with epilepsy. Epilepsia 1986, 27: 399-411.
6. Seidenberg M, O' Leary DS, Berent S, Boll TJ. Changes in seizures frequency and test-retest scores on the Wechsler intelligence scale, Epilepsia 1981, 22:75-83.
7. Jay MS, DuRant RH, Shoffitt T, Linder CW, Litt IF. Effect of peer counselors on adolescent compliance in use of oral contraceptives. Pediatrics 1984, 73:126-131.
8. Vining EPG, Mellits ED, Dorsen MM, et al. Psychologic and behavioral effects of antiepileptic drugs in children: A double-blind comparison between phenobarbital and valproic acid. Pediatrics 1987, 80: 165-174.
9. Mattson RH, Cramer JA, Collins JF, et al. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. N Engl J Med 1985, 313:145-151.
10. Bajaj RT, Kolhatkar UV. The current status of phenobarbitone use in childhood. Indian J Pediatr 1985, 52: 633-637.
11. Wolf SM, Forsythe A. Behavior disturbance, phenobarbital and febrile seizures. Pediatrics 1978, 61:728-731.
12. Camfield CS, Chaplin S, Doyle AB, et al. Side effects of phenobarbital in toddlers: Behavioral and cognitive aspects. J Pediatr 1979, 95:361-365.
13. Ferrari M, Barabas G, Matthews WS, Psychologic and behavioral disturbance among epileptic children treated with barbiturate anticonvulsants. Am J Psychiatry 1983, 140: 112-113.
14. Brent DA, Crumrine PK, Varma RR, Allan M, Allman C. Phenobarbital treatment and major depressive disorder in children with epilepsy. Pediatrics 1987, 80: 909-917.
15. Dodrill CB. Diphenylhydantoin serum levels, toxieity, and neuropsychological performance in patients with epilepsy. Epilepsia 1975, 16: 593-600.
16. Andrewes DG, Tomlinson L, Elwes RDC, et al. The influence of carbamazepine and phenytoin on memory and other aspects of cognitive functions in new referrals with epilepsy. Acta Neurol Scand 1983, 69 (Suppl 22): 23-30.
17. Vining EPG. Cognitive dysfunction associated with antiepileptic drug therapy. Epilepsia 1987, 28 (Suppl 2): S18-S22.
18. Trimble MR. Anticonvulsant drugs and cognitive function: A review of the literature. Epilepsia 1987, 28 (Suppl 3): S37-S45.
19. Trimble MR, Thompson PJ. Sodium valproate and cognitive function. Epilepsia 1984, 25 (Suppl 1): S60-S64.
20. Rall TW, Schleifer LS. Drugs effective in the therapy of epilepsies. In: Goodman and Oilman's: The Pharmacological Basis of Therapeutics, Vol. 1. Gilman AF, Rail TW, Nies AS, Taylor P. Eds. New York, Pergamon Press, 1990, pp 436-462.
21. Dodson WE. Special pharmacokinetic considerations in children. Epilepsia 1987, 28 (Suppl 1): S56-S70.