The role of enteric bacteria in the pathogenesis of fatal cycloheximide intolerance in mice pretreated with dexamethasone, promethazine or nordihydroguaiaretic acid

Inflammation Research

Volumn 45, Issue 7, 1996, Pages 354-356

  Parry, E W ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Cycloheximide; Drugs; Enteric bacteria

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYCLOHEXIMIDE; DEXAMETHASONE; LIPOPOLYSACCHARIDE; NORDIHYDROGUAIARETIC ACID; PROMETHAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; DRUG SENSITIZATION; ENTEROBACTERIACEAE; INTESTINE FLORA; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER FUNCTION; MALE; MORTALITY; MOUSE; NONHUMAN; PATHOGENESIS;

ANIMALS; BACTERIA; CYCLOHEXIMIDE; DEXAMETHASONE; INTESTINES; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED CBA; NORDIHYDROGUAIARETIC ACID; PROMETHAZINE; PROTEIN SYNTHESIS INHIBITORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030016866     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02252948     Document Type: Article

References (10)

1. Seyberth HW, Schmidt-Gayk H, Hackenthal E. Toxicicity, clearance and distribution of endotoxin as influenced by actinomycin-D, cycloheximide, α-amanitin and lead acetate. Toxicon 1972;10:491-500.
2. Parry EW. Factors involved in the fatal susceptibility to submicrogram doses of endotoxin in cycloheximide-treated mice. J Comp Pathol 1989;100:13-8.
3. Parry EW. A prolonged period of uninterrupted protein synthesis is essential for survival in mice given a submicrogram dose of endotoxin. J Comp Pathol 1993;109:101-4.
4. Gadina M, Bertini R, Mengozzi M, Zandalasini M, Mantovani A, Ghezzi P. Protective effect of chlorpromazine on endotoxin toxicity and TNF production in glucocorticoid sensitive and glucocorticoid resistant models of endotoxic shock. J Exp Med 1991;173:1305-10.
5. Bertini P, Garratini S, Delgado R, Ghezzi P. Pharmacological activities of chlorpromazine involved in the inhibition of tumour necrosis factor production in vivo in mice. Immunology 1993;79:217-9.
6. Van der Waaij D, Sturm CA. Antibiotic decontamination of the digestive tract of mice. Technical procedures. Lab Anim Care 1968;18:1-10.
7. Staruch MJ, Wood DD. Reduction of serum interleukin-1-like activity after treatment with dexamethasone. J Leukoc Biol 1985;37:193-207.
8. Beutler B, Krochin N, Milsark IW, Luedke C, Cerami A. Control of cachectin (tumour necrosis factor) synthesis: mechanisms of endotoxin resistance. Science 1986;232:977-80.
9. Nolan JP. The role of endotoxin in liver injury. Gastroenterology 1975;69:1346-56.
10. Trakatellis AL, Montjar M, Axelrod AE. Effect of cycloheximide on polysomes and protein synthesis in mouse liver. Biochemistry 1965;4:2065-71.