GM-CSF raises serum levels of β2-microglobulin and thymidine kinase in patients with chronic lymphocytic leukaemia

British Journal of Haematology

Volumn 94, Issue 1, 1996, Pages 129-132

  Itälä, Maija ^a   Pelliniemi, Tarja Terttu ^a   Remes, Kari ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Chronic lymphocytic leukaemia; Granulocyte macrophage colony stimulating factor; Lactate dehydrogenase; Thymidine kinase; 2 microglobulin

Indexed keywords

BETA 2 MICROGLOBULIN; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LACTATE DEHYDROGENASE; PREDNISONE; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; THYMIDINE KINASE;

AGED; ARTICLE; BLOOD LEVEL; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030016371     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.6172066.x     Document Type: Article

References (12)

1. 2-microglobulin: its significance and clinical usefulness. Annals of Clinical and Laboratory Science, 20, 163-168.
2. 2-microglobulin and immune activation. Clinical Chemistry, 35, 2158-2159.
3. Hallek, M., Wanders, L., Strohmayer, S. & Emmerich, B. (1992) Thymidine kinase: a tumour marker with prognostic value for non-Hodgkin's lymphoma and a broad range of potential clinical applications. Annals of Hematology, 65, 1-5.
4. 2,m) secretion by normal and leukaemic B cells: effects of recombinant cvtokines and evidence for a differential response to the combined stimulus of phorbol ester and calcium ionophore. British Journal of Cancer, 61, 675-680.
5. 2-microglobulin (β2m) level is more powerful than stage in predicting response and survival in chronic lymphocytic leukemia (CLL). Blood, 86, (Suppl. 1), 606a.
6. Källander, C.F.R., Simonsson, B., Hagberg, H. & Gronowitz, S. (1984) Serum deoxythymidine kinase gives prognostic information in chronic lymphocytic leukemia. Cancer, 54, 2450-2455.
7. Lee, J.S., Dixon, D.O., Kantarjian, H.M., Keating, M.J. & Talpaz, M. (1987) Prognosis of chronic lymphocytic leukemia: a multivariate regression analysis of 325 untreated patients. Blood, 69, 929-936.
8. Majlis, A., Sarris, A., Dimopoulos, M.A., Swan, F., Rodriguex, M.A., Younes, A. & Cabanillas, F. (1993) Treatment with G-CSF or GM-CSF and not tumor progression cause rising serum LDH during therapy of patients with lymphoma or myeloma. (Abstract). Blood, 82, (Suppl. 1), 572a.
9. Remes, K., Tienhaara, A. & Pelliniemi, T-T. (1993) Alpha Interferon raises serum beta-2-microglobulin in patients treated for thrombocythaemia. British Journal of Haematology, 84, 353-355.
10. 2-microglobulin by chronic lymphocytic leukaemia cells in vitro. Scandinavian Journal of Haematology, 36, 424-429.
11. Tötterman, T.H., Nilssson, K. & Simonsson, B. (1986) Phorbol ester-induced production of beta-2-microglobulin in B-CLL cells: relation to IgM secretory response and disease activity. British Journal of Haematology, 62, 95-103.
12. Vadhan-Raj, S., Velasquez, W.S., Butler, J.J., LeMaistre, A., Lepe-Zuniga, J., Keating, M.J., Koller, C.A. & Gutterman, J.U. (1990) Stimulation of myelopoiesis in chronic lymphocytic leukemia and other lymphoproliferative disorders by recombinant human granulocyte-macrophage colony-stimulating factor. American Journal of Hematology, 33, 189-197.