Nicotinamide pharmacokinetics in humans: Effect of gastric acid inhibition, comparison of rectal vs oral administration and the use of saliva for drug monitoring

British Journal of Cancer

Volumn 74, Issue 1, 1996, Pages 16-21

  Stratford, M R L ^a   Dennis, M F ^a   Hoskin, P ^a   Phillips, H ^a   Hodgkiss, R J ^a   Rojas, A ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

Nicotinamide; Omeprazole; Pharmacokinetics; Suppository

Indexed keywords

CHLORHEXIDINE; DRUG METABOLITE; NICOTINAMIDE; NICOTINIC ACID; OMEPRAZOLE;

ARTICLE; CASE REPORT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG METABOLISM; DRUG MONITORING; DRUG SALIVA LEVEL; DRUG UPTAKE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RECTAL DRUG ADMINISTRATION; STOMACH ACID SECRETION;

EID: 0030016338     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.309     Document Type: Article

References (10)

1. ELLISON PT. (1993). Measurements of salivary progesterone. Ann. N. Y. Acad. Sci., 694, 161-176.
2. HORSMAN MR, HOYER M, HONESS DJ, DENNIS IF AND OVERGAARD J. (1993). Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy. Radiother. Oncol, 27, 131-139.
3. HOSKIN PJ, STRATFORD MRL, SAUNDERS MI, HALL DW, DENNIS MF, AND ROJAS A. (1995). Administration of nicotinamide during CHART: pharmacokinetics, dose escalation and clinical toxicity. Int. J. Radiat. Oncol. Biol. Phys., 32, 1111-1119.
4. MAAZEN RWM v.d., THIJSSEN HOM, KAANDERS JHAM, KOSTER AD, KEYSER A, PRICK MJJ, GROTENHUIS JA, WESSELING P AND KOGEL AJ v.d. (1995). Conventional radiotherapy combined with carbogen breathing and nicotinamide for malignant gliomas. Radiother. Oncol, 35, 118-122.
5. MANDEL ID. (1993). Salivary diagnosis: promises, promises. Ann. N. Y. Acad. Sci., 94, 1-10.
6. STRATFORD MRL AND DENNIS MF. (1992). High-performance liquid chromatographic determination of nicotinamide and its metabolites in human and murine plasma and urine. J. Chromatogr., 582, 145-151.
7. STRATFORD MRL, ROJAS A, HALL DW, DENNIS MF, DISCHE S. JOINER MC AND HODGKISS RJ. (1992). Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers. Radiother. Oncol., 25, 37-42.
8. STRATFORD MRL, DENNIS MF, HOSKIN PJ, SAUNDERS M.I., HODGKISS R.J. AND ROJAS, A. (1996). Nicotinamide pharmacokinetics in normal volunteers and patients undergoing palliative radiotherapy. Acta Oncol., 35, 213-219.
9. WORKMAN P, WILTSHIRE CR, PLOWMAN PN AND BLEEHEN NM. (1978). Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring. Br. J. Cancer, 38, 709-718.
10. ZACKRISSON B, FRANZEN L, HENRIKSSON R, LITTBRAND B, STRATFORD M, DENNIS M, ROJAS A AND DENEKAMP J. (1994). Acute effects of accelerated radiotherapy in combination with carbogen breathing and nicotinamide (ARCON). Acta Oncol., 33, 377-381.