Expression of the multidrug resistance-associated protein (MRP) mRNA and protein in normal peripheral blood and bone marrow haemopoietic cells

British Journal of Haematology

Volumn 94, Issue 1, 1996, Pages 23-33

  Legrand, Ollivier ^a   Perrot, Jean Yves ^a   Tang, Ruoping ^a   Simonin, Ghislaine ^a   Gurbuxani, Sandeep ^a   Zittoun, Robert ^a   Marie, Jean Pierre ^a  

^a HÔTEL DIEU   (France)

Author keywords

In situ hybridization; mRNA; MRP; Normal haemopoietic cells; Protein

Indexed keywords

CALGRANULIN; MESSENGER RNA;

ARTICLE; BLOOD CELL; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; LEUKEMIA; LYMPHOMA; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

EID: 0030016285     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1776.x     Document Type: Article

References (41)

1. Abbaszadegan, M.R., Futscher, B.W., Klimecki, W.T., List, A. & Dalton, W.S. (1994) Analysis of multidrug resistance-associated protein (MRP) messenger RNA in normal and malignant hemalopoietic cells. Cancer Research, 54, 4676-4679.
2. Barrand, M.A., Heppell-Parton, A.C., Wright, K.A., Rabbitts, H. & Twentyman, P.R. (1994) A 190-kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene. Journal of the National Cancer Institute, 86, 110-117.
3. Beek, J., Handgretinger, R., Dopfer, R., Klingebiel, T., Niethammer, D. & Gekeler, V. (1995) Expression of mdr1, mrp, topoisomerase IIa/b, and cyclin A in primary or relapsed states of acute lymphoblastic leukaemias. British Journal of Haematology, 89, 356-363.
4. Bielder, J.L. & Riehm, H. (1970) Cellular resistance to actinomycin D in chinese hamster cells in vitro: cross resistance, radio-autographic and cytogenetic studies. Cancer Research, 30, 1174-1184.
5. Bradley, G., Juranka, P.F. & Ling, V. (1988) Mechanism of multidrug resistance. Biochimica et Biophysica Acta, 948, 87-128.
6. Burger, H., Nooter, K., Sonneveld, P., Van Wingerden, K.E., Zaman, G.J.R. & Stoter, G. (1994a) High expression of the multidrug resistance-associated protein (MRP) in chronic and prolymphocytic leukaemia. British Journal of Haematology, 88, 348-356.
7. Burger, H., Nooter, K., Zaman, G.J.R., Sonneveld, P., van Wingerden, K.E., Oostrum, R.G. & Stoter, G. (1994b) Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias. Leukemia, 8, 990-997.
8. Chaudhary, P.M. & Roninson, I.B. (1991) Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell, 66, 85-94.
9. Chomczynski, P. & Sacchi N. (1987) Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry, 62, 156-159.
10. Cole, S.P.C., Bhardwaj, G., Gerlach, J.H., Mackie, J.E., Grant, C.E., Almquist, K.C., Stewart, A.J., Kurz, E.U., Duncan, A.M.V. & Deeley, R.G. (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science, 258, 1650-1654.
11. Cole, S.P.C., Chanda, E.R. & Dicke, F.P. (1991) Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II. Cancer Research, 51, 3345-3352.
12. Cole, S.P.C. & Deeley, R.G. (1993) Multidrug resistance-associated protein: sequence correction. Science, 260, 879.
13. Drach, D., Zbao, S., Drach, J., Mahadevia, R., Gattringer, C., Huber, H. & Andreeff, M. (1992) Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype. Blood, 80, 2729-2734.
14. Endicott, J.A. & Ling, V. (1989) The biochemistry of P-glycoprotein mediated multidrug resistance. Annual Review of Biochemistry, 58, 137-171.
15. Flens, M.J., Izquierdo, M.A., Scheffer, G.L., Fritz, J.M., Meijer, C.J.L.M., Scheper, R.J. & Zaman, G.J.R. (1994) Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies. Cancer Research, 54, 4557-4563.
16. Futscher, B.W., Abbaszadegan, M.R., Domann, F. & Dalton, W.S. (1994) Analysis of MRP inRNA in mitoxantrone-selected, multidrug-resistant human tumor cells. Biochemistry and Pharmacology, 47, 1601-1606.
17. Grant, C.E., Valdimarsson, G., Hipfner, D.R., Almquist, K.C., Cole, S.P.C. & Deeley, R.G. (1994) Overexpression of multidrug resistance-associated protein (MRP) increase resistance to natural product drugs. Cancer Research, 54, 357-361.
18. Hart, S.M., Ganeshaguru, K., Hoffbrand, A.V., Prentice, H.G. & Mehta, A.B. (1994) Expression of the multidrug resistance-associated protein (MRP) in acute leukemia. Leukemia, 8, 2163-2168.
19. r 190000 multidrug protein, MRP. with monoclonal antibodies. Cancer Research, 54, 5788-5792.
20. Jedlitschky, G., Leier, I., Buchholz, U., Center, M. & Keppler, D. (1994) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Research, 54, 4833-4836.
21. Klimecki, W., Futscher, B.W., Grogan, T.M. & Dalton, W.S. (1994) P-glycoprotein expression and function in circulating blood cells from normal volunteers. Blood, 85, 2451-2458.
22. Krishnamachary, N. & Center, M.S. (1993) The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDA membrane bound glycoprotein. Cancer Research, 53, 3658-3661.
23. Kruch, G.D., Chan, A., Myers, K., Gaughan, K., Miki, T. & Aaranson, S.A. (1994) Expression complementary DNA library transfer establishes MRP as a multidrug resistance gene. Cancer Research, 54, 1649-1652.
24. Kuiper, C.M., Brozterman, H.J., Eekman, J.K., Ruhdal, K.A.B., Versantvoort, C.H.M., Pinedo, H.M. & Lankelma, J. (1994) Functional detection of MRP overexpression tumor cell lines using flow cytometry and laser scan microscopy. Proceedings of the American Association for Cancer Research, 35, 348 (abstract 2074).
25. Marie, J.P., Brophy, N.A., Ehsan, M.M., Aihara, Y., Mohamed, N.A., Cornbleet, J., Chao, N.J. & Sikic, B.I. (1942) Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells. British Journal of Haematology, 81, 145-152.
26. Marie, J.P., Simonin, G., Legrand, O., Delmer, A., Faussat, A.M., Lewis, A.D., Sikic, B.I. & Zittoun, R. (1995) Glutathione -S-transferases π. α. μ and mdr1 mRNA expression in normal lymphocytes and chronic lymphocytic leukemia. Leukemia, 9, 1742-1747.
27. McGrath, T. & Center, M.S. (1987) Adriamycin resistance in HL60 cells in the absence of detectable P-glycoprotein. Biochemical and Biophysical Research Communications. 145, 1171-1176.
28. Müller, M., Meijer, C., Zaman, G.J.R., Borst, P., Scheper, R.J., Mulder, N.H., de Vries, E.G.E. & Jansen, P.L.M. (1994) Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Prceedings of the National Academy of Sciences of the United States of America, 91, 13033-13037.
29. Murphy, L.D., Herzog, C.E., Rudick, J.B., Fojo, A.T. & Bates, S.E. (1990) Use of the polymerase chain reaction in the quantitation of mdr1 expression. Biochemistry, 29, 10351-10356.
30. Neyfakh, A.A., Serpinskaya, A.S., Chervonsky, A.V., Apasov, S.G. & Kazarov, A.R. (1989) Multidrug-resistance phenotype of a subpopulation of T lymphocytes without drug selection. Experimental Cell Research, 185, 496-505.
31. Noonan, K.E. & Roninson I.B. (1991) Quantitative estimation of MDRI mRNA levels by polymerase chain reaction. Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells (ed. by I. B. Robinson), pp. 319-333. Plenum Press, New York.
32. Pastan, I. & Gottesman, M.M. (1987) Multiple-drug resistance in human cancer. New England Journal of Medicine, 316, 1388-1393.
33. Schneider, E., Cowan, K.H., Bader, H., Toomey, S., Schwartz, G.N. Karp, J.E., Burke, P.J. & Kaufmann, S.H. (1995) Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia. Blood, 85, 186-193.
34. Schneider, E., Horton, J.K., Yang, C.H., Nakagawa, M. & Cowan, K.H. (1994) Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance. Cancer Research, 54, 152-158.
35. Slovak, M.L., Pelkey, H., Bhardwaj, G., Kurz, E.U., Deeley, R.G. & Cole, S.P.C. (1993) Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines. Cancer Research, 53, 3321-3225.
36. Twentyman, P.R., Rhodes, T. & Rayner, S. (1994) A comparison of rhodamine 123 accumulation and efflux in cells with p-glycoprotein-mediated and MRP-associated multidrug resistance phenotypes. European Journal of Cancer, 30A, 1360-1369.
37. Zaman, G.J.R., Flens, M.J., van Leusden, M.R., de Haas, M., Mülder, H.S., Lankelma, J., Pinedo, H.M., Scheper, R.J., Baas, F., Broxterman, H.J. & Borst, P. (1994) The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proceedings of the National Academy of Sciences of the United States of America, 91, 8822-8826.
38. Zaman, G.J.R., Lankelma, J., van Tellingen, O., Beijnen, J., Dekker, H., Paulusma, C., Oude Elferink, R.P.J., Baas, F. & Borst, P. (1995) Role of glutathione in export of compounds from cells by the multidrug-resistance associated protein. Proceedings of the National Academy of Sciences of the United States of America. 92, 7690-7694.
39. Zaman, G.J.R., Versantvoort, C.H.M., Smith, J.J.M., Eijmdems, E.W.H.M., de Haas, M., Smith, A.J., Broxterman, H.J., Mulder, N.H., de Vries, E.G.E., Baas, F. & Borst, P. (1993) Analysis of the expression of MRP, the gene for a new putative transmembrane drug efflux transporter, in human multidrug resistant lung cancer cell lines. Cancer Research, 53, 1747-1750.
40. Zhou, D.C., Hoang-Ngoc, L., Delmer, A., Faussat, A.M., Russo, D., Sittoun, R. & Marie, J.P. (1994) Expression of resistance genes in acute leukemia. Leukemia and Lymphoma, 13, 27-30.
41. Zhou, D.Z., Zittoun, R. & Marie, J.P. (1995) Expression of multidrug resistance-associated protein (MRP) and multidrug resistance (MDRI) genes in acute myeloid leukemia. Leukemia, 9, 1661-1666.