Differential humoral immune response against hepatitis C virus antigenic synthetic peptides in infected patients with and without mixed cryoglobulinaemia

Clinical and Experimental Immunology

Volumn 105, Issue 1, 1996, Pages 59-64

  Gabrielli, A ^a,e   Zhang, Z X ^b   Cherubini, G ^a   Candela, M ^a   Savoldi, S ^c   Manzin, A ^a   Clementi, M ^a   Amoroso, A ^d   Sallberg, M ^b  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c Ospedale Civile di Brescia   (Italy)

^d UNIVERSITY OF TURIN   (Italy)

^e Ospedale Regionale Torrette   (Italy)

Author keywords

cryoglobulinaemia; hepatitis C virus; immunity; infection

Indexed keywords

ANTIBODY; CRYOGLOBULIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; SYNTHETIC PEPTIDE; VIRUS RNA;

ADULT; AGED; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYOGLOBULINEMIA; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOTYPE; HEPATITIS C; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMORAL IMMUNITY; IMMUNOELECTROPHORESIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0030016033     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.d01-720.x     Document Type: Article

References (31)

1. Gorevic PD, Kassab HJ, Levo Y et al. Mixed cryoglobulinemia: clinical aspects and long term follow up of 40 patients. Am J Med 1980;69:287-308.
2. Brouet JC, Clauvel JP, Danon F et al. Biologic and clinical significance of cryoglobulins: a report of 86 cases. Am J Med 1974;57:775-88.
3. Lo Spalluto, Dorward JB, Miller Jr W et al. Cryoglobulinemia based on interaction between a gamma macroglobulin and 7S gamma globulin. Am J Med 1962;32:142-7.
4. Meltzer M, Franklin EC, Elias K et al. Cryoglobulinemia - a clinical and laboratory study. II. Cryoglobulins with rheumatoid factor activity. Am J Med 1966;40:837-56.
5. Grey HM, Kohler PF, Terry WD et al. Human monoclonal γG-cryoglobulins with anti-γ-globulin activity. J Clin Invest 1968;47:1875-84.
6. Realdi G, Alberti A, Rigoli A, Tremolada F. Immune-complexes and Australia antigen in cryoglobulinemic sera. Z Immunitaets-forsch 1974;147:114-26.
7. Levo Y, Gorevic PD, Kassab HJ et al. Association between hepatitis B virus and essential mixed cryoglobulinemia. N Engl J Med 1977;296:1501-4.
8. Fiorini GF, Bernasconi P, Sinico RA et al. Increased frequency of antibodies to ubiquitous viruses in essential mixed cryoglobulinemia. Clin Exp Immunol 1986;64:65-70.
9. Casato M, Taliani G, Pucillo LP et al. Cryoglobulinemia and hepatitis C virus. Lancet 1991;337:1047-8.
10. Ferri C, Greco F, Longobardo G et al. Antibodies to hepatitis C virus in patients with mixed cryoglobulinemia. Arthritis Rheum 1991;34:1606-10.
11. Dammacco F, Sansonno D. Antibodies to hepatitis C virus in essential mixed cryoglobulinemia. Clin Exp Immunol 1992;87:352-6.
12. Misiani R, Bellavita P, Fenili D et al. Hepatitis C virus infection in patients with essential mixed cryoglobulinemia. Ann Intern Med 1992;117:573-7.
13. Cacoub P, Lunel Fabiani F, Musset L et al. Mixed cryoglobulinemia and hepatitis C virus. Am J Med 1994;96:124-32.
14. Ferri C, Greco F, Longobardo G et al. Association between hepatitis C virus and mixed cryoglobulinemia. Clin Exp Rheumatol 1991;9:621-4.
15. Agnello V, Chung RT, Kaplan LM. A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med 1992;327:1490-5.
16. Gabrielli A, Manzin A, Candela M et al. Active hepatitis C virus infection in bone marrow and peripheral blood mononuclear cells from patients with mixed cryoglobulinemia. Clin Exp Immunol 1994;97:87-93.
17. Ferri C, Monti M, La Civita L et al. Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobulinemia. Blood 1993;82:3701-4.
18. Sallberg M, Ruden U, Wahren B et al. Immunodominant regions within the hepatitis C virus core and putative matrix proteins. J Clin Microbiol 1992;30:1989-94.
19. Sallberg M, Ruden U, Wahren B et al. Antigenic regions within the hepatitis C virus envelope 1 and non-structural proteins: identification of an IgG3-restricted recognition site within the envelope 1 protein. Clin Exp Immunol 1993;91:489-94.
20. Zhang Z-X, Chen M, Sonnerborg A et al. Antigenic structure of the complete nonstructural (NS) 2 and 5 proteins of hepatitis C virus (HCV): anti HCV NS2 and NS5 antibody reactivities in relation to HCV serotype, presence of HCV RNA and acute HCV infection. Clin Diagn Lab Immunol 1994;1:290-4.
21. Okamoto H, Sugiyama Y, Okada S et al. Typing hepatitis C virus by polymerase chain reaction with type specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol 1992;73:673-9.
22. Okamoto H, Tokita H, Sakamoto M et al. Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection. J Gen Virol 1993;74: 2385-90.
23. Silini E, Bono F, Cerino A et al. Virological features of hepatitis C virus infection in hemodialysis patients. J Clin Microbiol 1993;31:2913-7.
24. Simmonds P, Holmes EC, Cha TA et al. Classification of hepatitis C virus into six major genotypes by phylogenetic analysis of the NS-5 region. J Gen Virol 1993;74:2391-9.
25. Sallberg M, Ruden U, Magnius LO et al. Rapid "tea-bag" peptide synthesis using 9-fluorenylmethoxycarbonyl (Fmoc) protected aminoacids applied for antigenic mapping of viral protein. Immunol Lett 1991;30:50-68.
26. Powell R, Agnello V. Characterization of complement fixing activity and cross-idiotypes of rheumatoid factors in idiopathic mixed cryoglobulinemia. Clin Exp Immunol 1983;29:146-51.
27. Capra JD, Kunkel HG. Amino acid sequence similarities in two human anti gamma globulin antibodies. Proc Natl Acad Sci USA 1970;67:87-90.
28. Cream JJ, Howard A, Virella G. IgG heavy-chain sub-classes in mixed cryoglobulinemia. Immunology 1972;23:405-11.
29. Abdelmoula M, Spertini F, Shibata T et al. IgG3 is the major source of cryoglobulins in mice. J Immunol 1989;143:526-32.
30. Werner C, Joller-Jemelka HI, Fontana A. Hepatitis C virus and cryoglobulinemia. N Engl J Med 1993;328:1122-3.
31. Galli M, Monti G, Monteverde A et al. Hepatitis C virus and mixed cryoglobulinemia. Lancet 1992;339:989.