The metabolite profile of radioisotope-labeled biotin in rats indicates that rat biotin metabolism is similar to that in humans

Journal of Nutrition

Volumn 126, Issue 7, 1996, Pages 1852-1857

  Wang, Kuen Shian ^a   Patel, Amit ^a   Mock, Donald M ^a  

^a NONE

Author keywords

biotin; biotin metabolite; rats; urine

Indexed keywords

BIOTIN; BIOTIN DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; DRUG EXCRETION; DRUG METABOLISM; ISOTOPE LABELING; MALE; NONHUMAN; RAT; URINARY EXCRETION; VITAMIN INTAKE;

ANIMALS; BIOTIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; HUMANS; INJECTIONS, INTRAPERITONEAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

ANIMALIA;

EID: 0030015513     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Chastain, J. L., Bowers-Komro, D. M. & McCormick, D. B. (1985) High-performance liquid chromatography of biotin and analogues. J. Chromatogr. 330: 153-158.
2. 14C-carbonyl-labeled biotin d-sulfoxide. J. Biol. Chem. 245: 6269-6273.
3. Krause, K.-H., Bonjour, J.-P., Berlit, P., Kynast, G., Schmidt-Gayk, H. & Schellenberg, B. (1988) Effect of long-term treatment with antiepileptic drugs on vitamin status. Drug Nutr. Interact. 5: 317-343.
4. Lee, H. M., Wright, L. D. & McCormick, D. B. (1972) Metabolism of carbonyl-labeled [14C] biotin in the rat. J. Nutr. 102: 1453-1464.
5. Mock, D. M. & Dyken, M. E. (1995) Biotin deficiency results from long-term therapy with anticonvulsants. Gastroenterology 108: A740 [abs.].
6. Mock, D. M., Lankford, G. L. & Cazin, J., Jr. (1993) Biotin and biotin analogs in human urine: biotin accounts for only half of the total. J. Nutr. 123: 1844-1851.
7. Mock, D. M., Mock, N. I. & Langbehn, S. E. (1992) Biotin in human milk: methods, location, and chemical form. J. Nutr. 122: 535-545.
8. Mock, D. M., Mock, N. I., Stratton, S. L. &. Stadler, D. D. (1995) Urinary excretion of biotin decreases during pregnancy, providing evidence of decreased biotin status. FASEB J. 9: A155 (abs.).
9. Sydenstricker, V. P., Singal, S. A., Briggs, A. P. & DeVaughn, N. M. (1942) Preliminary observations on "Egg white injury in man and its cure with a biotin concentrate." Science 95: 176-177.