메뉴 건너뛰기




Volumn 157, Issue 2, 1996, Pages 763-771

Somatically mutated B cell pool provides precursors for insulin antibodies

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; AUTOANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN HEAVY CHAIN; INSULIN; INSULIN ANTIBODY; MONOCLONAL ANTIBODY;

EID: 0030015510     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (24)

References (39)
  • 1
    • 77956751025 scopus 로고
    • Insulin: The structure in the crystal and its reflection in chemistry and biology
    • Blundell, T., G. Dodson, D. Hodgkin, and D. Mercola. 1972. Insulin: the structure in the crystal and its reflection in chemistry and biology. Adv. Protein Chem. 26:279.
    • (1972) Adv. Protein Chem. , vol.26 , pp. 279
    • Blundell, T.1    Dodson, G.2    Hodgkin, D.3    Mercola, D.4
  • 3
    • 0020545136 scopus 로고
    • Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus
    • Blackshear, J., H. E. Rotner, K. A. M. Kriauciunas, and C. R. Kahn. 1983. Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus. Ann. Intern. Med. 99:182.
    • (1983) Ann. Intern. Med. , vol.99 , pp. 182
    • Blackshear, J.1    Rotner, H.E.2    Kriauciunas, K.A.M.3    Kahn, C.R.4
  • 5
    • 0023871715 scopus 로고
    • Autoantibodies to insulin are present in sera of patients with autoimmune thyroid disease
    • Nuovo, J. A., J. R. Baker, L. Wartofsky, Y. G. Lukes, and K. O. Burman. 1988. Autoantibodies to insulin are present in sera of patients with autoimmune thyroid disease. Diabetes 37:317.
    • (1988) Diabetes , vol.37 , pp. 317
    • Nuovo, J.A.1    Baker, J.R.2    Wartofsky, L.3    Lukes, Y.G.4    Burman, K.O.5
  • 6
    • 0024425654 scopus 로고
    • + B lymphocytes, polyreactive antibodies and the human B cell repertoire
    • + B lymphocytes, polyreactive antibodies and the human B cell repertoire. Immunol. Today 10:364.
    • (1989) Immunol. Today , vol.10 , pp. 364
    • Casali, P.1    Notkins, A.L.2
  • 7
    • 0026627765 scopus 로고
    • Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: Results of the Fourth International Workshop on the Standardization
    • Greenbaum, C. J., J. P. Palmer, B. Kuglin, and H. Kolb. 1992. Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: results of the Fourth International Workshop on the Standardization. J. Clin. Endocrinol. Metab. 74:1040.
    • (1992) J. Clin. Endocrinol. Metab. , vol.74 , pp. 1040
    • Greenbaum, C.J.1    Palmer, J.P.2    Kuglin, B.3    Kolb, H.4
  • 8
    • 0025234628 scopus 로고
    • Type I diabetes: A chronic autoimmune disease of human, mouse and rat
    • Castaño, L., and G. S. Eisenbarth. 1990. Type I diabetes: a chronic autoimmune disease of human, mouse and rat. Annu. Rev. Immunol. 8:647.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 647
    • Castaño, L.1    Eisenbarth, G.S.2
  • 9
    • 0026762942 scopus 로고
    • Transgenic mice and analysis of B-cell tolerance
    • Goodnow, C. C. 1992. Transgenic mice and analysis of B-cell tolerance. Annu. Rev. Immunol. 10:489.
    • (1992) Annu. Rev. Immunol. , vol.10 , pp. 489
    • Goodnow, C.C.1
  • 10
    • 0020510712 scopus 로고
    • Mapping epitopes on the insulin molecule using monoclonal antibodies
    • Schroer, J. A., T. Bendis, R. J. Feldman, and K. J. Kim. 1983. Mapping epitopes on the insulin molecule using monoclonal antibodies. Eur. J. Immunol. 13:693.
    • (1983) Eur. J. Immunol. , vol.13 , pp. 693
    • Schroer, J.A.1    Bendis, T.2    Feldman, R.J.3    Kim, K.J.4
  • 11
    • 0025193410 scopus 로고
    • L gene usage by murine IgG antibodies that bind autologous insulin
    • L gene usage by murine IgG antibodies that bind autologous insulin. J. Immunol. 144:3091.
    • (1990) J. Immunol. , vol.144 , pp. 3091
    • Ewulonu, U.K.1    Nell, L.J.2    Thomas, J.W.3
  • 12
    • 0026673489 scopus 로고
    • Anti-insulin and regulatory anti-idiotypic antibodies use the same germ-line VHIX gene
    • Thomas, J. W. 1992. Anti-insulin and regulatory anti-idiotypic antibodies use the same germ-line VHIX gene. Eur. J. Immunol. 22:2445.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2445
    • Thomas, J.W.1
  • 13
    • 0028969406 scopus 로고
    • VH gene structure predicts a large potential anti-insulin repertoire
    • Mitchell, H. C., and J. W. Thomas. 1995. VH gene structure predicts a large potential anti-insulin repertoire. Mol. Immunol. 32:311.
    • (1995) Mol. Immunol. , vol.32 , pp. 311
    • Mitchell, H.C.1    Thomas, J.W.2
  • 15
    • 0026782894 scopus 로고
    • Characterization of germ-line genes of the VGAM3.8 VH gene family from BALB/c mice
    • Sims, M. J., U. Krawinkel, and M. J. Taussig. 1992. Characterization of germ-line genes of the VGAM3.8 VH gene family from BALB/c mice. J. Immunol. 149: 1642.
    • (1992) J. Immunol. , vol.149 , pp. 1642
    • Sims, M.J.1    Krawinkel, U.2    Taussig, M.J.3
  • 16
    • 0027179093 scopus 로고
    • Molecular and kinetic analysis of an epitope-specific shift in the B cell memory response to a multideterminant antigen
    • Press, J. L., and C. A. Giorgetti. 1993. Molecular and kinetic analysis of an epitope-specific shift in the B cell memory response to a multideterminant antigen. J. Immunol. 151:1998.
    • (1993) J. Immunol. , vol.151 , pp. 1998
    • Press, J.L.1    Giorgetti, C.A.2
  • 17
    • 0022160410 scopus 로고
    • Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes
    • Winter, E., A. Radbruch, and U. Krawinkel. 1985. Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes. EMBO J. 4:2861.
    • (1985) EMBO J. , vol.4 , pp. 2861
    • Winter, E.1    Radbruch, A.2    Krawinkel, U.3
  • 18
  • 19
    • 0026743070 scopus 로고
    • Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen
    • Brink, R., C. C. Goodnow, J. Crosbie, E. Adams, J. Eris, D. Y. Mason, S. B. Hartley, and A. Basten. 1992. Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen. J. Exp. Med. 176:991.
    • (1992) J. Exp. Med. , vol.176 , pp. 991
    • Brink, R.1    Goodnow, C.C.2    Crosbie, J.3    Adams, E.4    Eris, J.5    Mason, D.Y.6    Hartley, S.B.7    Basten, A.8
  • 20
    • 0021711635 scopus 로고
    • The identification of monoclonal class switch variants by Sib selection and an ELISA assay
    • Spira, G., A. Bargellesi, J.-L. Teillaud, and M. D. Scharff. 1984. The identification of monoclonal class switch variants by Sib selection and an ELISA assay. J. Immunol. Methods 74:307.
    • (1984) J. Immunol. Methods , vol.74 , pp. 307
    • Spira, G.1    Bargellesi, A.2    Teillaud, J.-L.3    Scharff, M.D.4
  • 21
    • 0025975980 scopus 로고
    • Electroporalion of lymphoid cells: Factors affecting the efficiency of transfection
    • Anderson, M. L., D. A. Spandidos, and J. R. Coggins. 1991. Electroporalion of lymphoid cells: factors affecting the efficiency of transfection. J. Biochem. Biophys. Methods 22:207.
    • (1991) J. Biochem. Biophys. Methods , vol.22 , pp. 207
    • Anderson, M.L.1    Spandidos, D.A.2    Coggins, J.R.3
  • 22
    • 2642699794 scopus 로고
    • Rapid and efficient site-specific mutagenesis without phenotypic selection
    • Kunkel, T. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 488
    • Kunkel, T.1
  • 23
    • 0024514560 scopus 로고
    • Human insulin autoantibody fine specificity and H and L chain use
    • Nell, L. J., C. Hulbert, and J. W. Thomas. 1989. Human insulin autoantibody fine specificity and H and L chain use. J. Immunol. 142:3063.
    • (1989) J. Immunol. , vol.142 , pp. 3063
    • Nell, L.J.1    Hulbert, C.2    Thomas, J.W.3
  • 24
    • 0018760671 scopus 로고
    • H-2-linked Ir gene control of antibody responses to insulin. I. Anti-insulin plaque forming cell primary responses
    • Schroer, J. A., J. K. Inman, J. W. Thomas, and A. S. Rosenthal. 1979. H-2-linked Ir gene control of antibody responses to insulin. I. Anti-insulin plaque forming cell primary responses. J. Immunol. 123:670.
    • (1979) J. Immunol. , vol.123 , pp. 670
    • Schroer, J.A.1    Inman, J.K.2    Thomas, J.W.3    Rosenthal, A.S.4
  • 25
    • 0023201150 scopus 로고
    • Unusual immunoglobulin DNA sequences from the nonexpressed chromosome of mouse normal B lymphocytes: Implications for allelic exclusion and the DNA rearrangmeent process
    • Nottenburg, C., T. St. John, and I. L. Weissman. 1987. Unusual immunoglobulin DNA sequences from the nonexpressed chromosome of mouse normal B lymphocytes: implications for allelic exclusion and the DNA rearrangmeent process. J Immunol. 139: 1718.
    • (1987) J Immunol. , vol.139 , pp. 1718
    • Nottenburg, C.1    St. John, T.2    Weissman, I.L.3
  • 26
    • 0021997580 scopus 로고
    • Heterogeneity and specificity of human anti-insulin antibodies determined by isoelectric focusing
    • Thomas, J. W., V. J. Virta, and L. J. Nell. 1985. Heterogeneity and specificity of human anti-insulin antibodies determined by isoelectric focusing. J. Immunol. 134: 1048.
    • (1985) J. Immunol. , vol.134 , pp. 1048
    • Thomas, J.W.1    Virta, V.J.2    Nell, L.J.3
  • 27
    • 0025896331 scopus 로고
    • Many variable region genes are utilized in the antibody response of BALB/c mice to the influenza virus A/PR/8/34 hemagglutinin
    • Caton, A. J., S. E. Stark, J. Kavaler, L. M. Staudt, D. Schwartz, and W. Gerhard. 1991. Many variable region genes are utilized in the antibody response of BALB/c mice to the influenza virus A/PR/8/34 hemagglutinin. J. Immunol. 147: 1675.
    • (1991) J. Immunol. , vol.147 , pp. 1675
    • Caton, A.J.1    Stark, S.E.2    Kavaler, J.3    Staudt, L.M.4    Schwartz, D.5    Gerhard, W.6
  • 28
    • 0025067385 scopus 로고
    • Crystal structure of the antigen-binding frament of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-Å resolution
    • Rose, D. R., R. K. Strong, M. N. Margolies, M. L. Gefter, and G. A. Petsko. 1990. Crystal structure of the antigen-binding frament of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-Å resolution. Proc. Natl. Acad. Sci. USA 87:338.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 338
    • Rose, D.R.1    Strong, R.K.2    Margolies, M.N.3    Gefter, M.L.4    Petsko, G.A.5
  • 29
    • 0025358376 scopus 로고
    • Structural correlates of high antibody affinity: Three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold
    • Sharon, J. 1990. Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold. Proc. Natl. Acad. Sci. USA 87:4814.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 4814
    • Sharon, J.1
  • 30
    • 0026440143 scopus 로고
    • Antigen binding and idiotype analysis of antibodies obtained after electroporation of heavy and light chain genes encoding phosphocholine-specific anitbodies: A model for T15-idiotype dominance
    • Kenny, J. J., C. M. Moratz, G. Guelde, C. D. O'Connell, J. George, C. Dell, S. J. Penner, J. S. Weber, J. Berry, J. L. Claflin, and D. L. Longo. 1992. Antigen binding and idiotype analysis of antibodies obtained after electroporation of heavy and light chain genes encoding phosphocholine-specific anitbodies: a model for T15-idiotype dominance. J. Exp. Med. 176:1617.
    • (1992) J. Exp. Med. , vol.176 , pp. 1617
    • Kenny, J.J.1    Moratz, C.M.2    Guelde, G.3    O'Connell, C.D.4    George, J.5    Dell, C.6    Penner, S.J.7    Weber, J.S.8    Berry, J.9    Claflin, J.L.10    Longo, D.L.11
  • 31
    • 0026782891 scopus 로고
    • A single amino acid mutation in CDR3 of the 3-14-9 L chain abolished expression of the IDA 10-defined idiotope and antigen binding
    • Hall, B. L., H. Zaghouani, C. Daian, and C. A. Bona. 1992. A single amino acid mutation in CDR3 of the 3-14-9 L chain abolished expression of the IDA 10-defined idiotope and antigen binding. J. Immunol. 149:1605.
    • (1992) J. Immunol. , vol.149 , pp. 1605
    • Hall, B.L.1    Zaghouani, H.2    Daian, C.3    Bona, C.A.4
  • 32
    • 0003575039 scopus 로고
    • Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
    • Kocks, C., and K. Rajewsky. 1988. Stepwise intraclonal maturation of antibody affinity through somatic hypermutation. Proc. Natl. Acad. Sci. USA 85:8206.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 8206
    • Kocks, C.1    Rajewsky, K.2
  • 33
    • 0025335392 scopus 로고
    • H joining: Implications for the joining mechanism and ontogenic timing of Ly-1 cell and B-CLL progenitor generation
    • H joining: implications for the joining mechanism and ontogenic timing of Ly-1 cell and B-CLL progenitor generation. EMBO J. 9:2133.
    • (1993) EMBO J. , vol.9 , pp. 2133
    • Gu, H.1    Forster, I.2    Rajewsky, K.3
  • 34
  • 35
    • 0025981495 scopus 로고
    • Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response
    • Fish, S., M. Fleming, J. Sharon, and T. Manser. 1991. Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response. J. Exp. Med. 173:665.
    • (1991) J. Exp. Med. , vol.173 , pp. 665
    • Fish, S.1    Fleming, M.2    Sharon, J.3    Manser, T.4
  • 37
    • 0028837355 scopus 로고
    • A human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific "germ-line" natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis
    • Ichiyoshi, Y., M. Zhou, and P. Casali. 1995. A human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific "germ-line" natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis. J. Immunol. 154:226.
    • (1995) J. Immunol. , vol.154 , pp. 226
    • Ichiyoshi, Y.1    Zhou, M.2    Casali, P.3
  • 38
    • 0024025048 scopus 로고
    • Sequences of 12 monoclonal anti-dinitrophenyl spin-labeled antibodies for NMR studies
    • Leahy, D. J., G. S. Rule, M. M. Whittaker, and H. M. McConnell. 1988. Sequences of 12 monoclonal anti-dinitrophenyl spin-labeled antibodies for NMR studies. Proc. Natl. Acad. Sci. USA 85:3661.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3661
    • Leahy, D.J.1    Rule, G.S.2    Whittaker, M.M.3    McConnell, H.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.