Prolonged antinociceptive effect after epidural injection of polyethylene glycol-morphine composites in rats

Japanese Journal of Anesthesiology

Volumn 45, Issue 5, 1996, Pages

  Okuda, Takahiko ^a   Tsuchiya, Norio ^a   Wakita, Katsutoshi ^a   Hatsuoka, Kazuki ^a   Koga, Yoshihisa ^a   Ueda, Shinji ^b   Kaetsu, Isao ^b  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL; MORPHINE;

ANIMAL EXPERIMENT; ARTICLE; CANCER PAIN; CANCER PATIENT; DRUG EFFECT; EPIDURAL ANESTHESIA; EPIDURAL DRUG ADMINISTRATION; EPIDURAL SPACE; INTRAMUSCULAR DRUG ADMINISTRATION; NOCICEPTION; NONHUMAN; RAT;

ANALGESICS, OPIOID; ANIMALS; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; INJECTIONS, EPIDURAL; MORPHINE; PAIN MEASUREMENT; POLYETHYLENE GLYCOLS; RATS; TIME FACTORS;

EID: 0030015152     PISSN: 00214892     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Langerman L, Grant GJ, Zakowski M, et al : Prolongation of spinal anesthesia. Anesthesiology 77 : 475, 1992
2. Mashimo T, Uchida I, Yoshiya I, et al : Prolongation of canine epidural anesthesia by liposome encapsulation of lidocaine. Anesth Analg 74 : 827, 1992
3. Doherty MM, Hughes PJ, Charman WN, et al : Prolongation of lidocaine-induced epidural anesthesia by medium molecular weight hyaluronic acid formulations : Pharmacodynamic and pharmacokinetic studies in the rabbit. Anesth Analg 80 : 740, 1995
4. Sato S, Baba Y, Sato Y, et al : Prolongation of epidural anesthesia in rabbit with the use of a biodegradable copolymer paste containing lidocaine. Anesth Analg 180 : 97, 1995
5. Masters DB, Berde CB, Langer R, et al : Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix. Anesthesiology 79 : 340, 1993
6. Grant GJ, Vermeulen K, Langerman L, et al : Prolonged analgesia and decreased toxicity with liposomal morphine in a mouse model. Anesth Analg 79 : 706, 1994
7. Bernards CM, Luger TJ, Yaksh TL, et al : Liposome encapsulation prolongs alfentanil spinal analgesia and alters systemic redistribution in the rat. Anesthesiology 77 : 529, 1992
8. Wallace MS, Yanez AM, Yaksh TL, et al : Antinociception and side effects of liposomeencapsulated alfentanil after spinal delivery in rats. Anesth Analg 79 : 778, 1994
9. Swinyard EA, Pathak MA : Surface-acting drugs, Goodman and Gilman's the Pharmacological Basis of Therapeutics. Edited by Gilman AG, et al. New York, Macmillan Publishing Company, 1985, pp946-958