-
1
-
-
0028344047
-
Synthesis and aldose reductase inhibitory activity of 2-substituted - 6-fluoro - 2,3 - dihydrospiro[4H - 1 - benzopyran - 4,4′ - imidazolidine]-2′,5′-diones
-
Yamaguchi, T., Miura, K , Usui, T., Unno, R., Matsumoto, Y., Fukushima, M , Mizuno, K., Kondo, Y., Baba, Y., Kurono, M. Synthesis and aldose reductase inhibitory activity of 2-substituted - 6-fluoro - 2,3 - dihydrospiro[4H - 1 - benzopyran - 4,4′ - imidazolidine]-2′,5′-diones Arzneim-Forsch-Drug Res 1994, 44: 344-8.
-
(1994)
Arzneim-Forsch-Drug Res
, vol.44
, pp. 344-348
-
-
Yamaguchi, T.1
Miura, K.2
Usui, T.3
Unno, R.4
Matsumoto, Y.5
Fukushima, M.6
Mizuno, K.7
Kondo, Y.8
Baba, Y.9
Kurono, M.10
-
2
-
-
15844419054
-
-
Hydantoin derivs, for treating complications of diabetes. EP 264586, JP 88057588, JP 88126881, JP 88250373, US 4861792, US 4978758, US 5447946
-
Kurono, M., Kondo, Y., Yamaguchi, T.et al. (Sanwa Kagaku Kenkyusho Co., Ltd.). Hydantoin derivs, for treating complications of diabetes. EP 264586, JP 88057588, JP 88126881, JP 88250373, US 4861792, US 4978758, US 5447946.
-
-
-
Kurono, M.1
Kondo, Y.2
Yamaguchi, T.3
-
3
-
-
2642644084
-
Treatment of diabetic complications
-
Prous Science Publishers, Barcelona
-
Prous, J.R. Treatment of diabetic complications. In: The Year's Drug News - Therapeutic Targets, 1994 Edition, Prous Science Publishers, Barcelona, 1994, 275-9.
-
(1994)
The Year's Drug News - Therapeutic Targets, 1994 Edition
, pp. 275-279
-
-
Prous, J.R.1
-
4
-
-
0025119897
-
Profile of a new aldose reductase inhibitor, (2S,4S)-6-fluoro-2′,5′-dioxospiro-[chroman-4,4′-imidazolidine] -2-carboxamide (SNK-860)
-
Mizuno, K., Yamaguchi, T., Inoue, A. et al. Profile of a new aldose reductase inhibitor, (2S,4S)-6-fluoro-2′,5′-dioxospiro-[chroman-4,4′-imidazolidine] -2-carboxamide (SNK-860). Int Cong Ser-Excerpta Med 1990, 913: 89-96.
-
(1990)
Int Cong Ser-Excerpta Med
, vol.913
, pp. 89-96
-
-
Mizuno, K.1
Yamaguchi, T.2
Inoue, A.3
-
5
-
-
0029079288
-
Effects of glucose and SNK-860, an aldose reductase inhibitor, on the polyol pathway and chemiluminescence response of human neutrophils in vitro
-
Kawamura, T., Suzuki, K., Matsumae, H., Sano, T., Sakamoto, N , Hotta, N. Effects of glucose and SNK-860, an aldose reductase inhibitor, on the polyol pathway and chemiluminescence response of human neutrophils in vitro. Diabetic Med 1995, 12: 392-6.
-
(1995)
Diabetic Med
, vol.12
, pp. 392-396
-
-
Kawamura, T.1
Suzuki, K.2
Matsumae, H.3
Sano, T.4
Sakamoto, N.5
Hotta, N.6
-
6
-
-
15844415690
-
Aldose reductase inhibition prevents glucose-induced overproduction of type IV collagen in cultured mesangial cells
-
Kikkawa, R., Haneda, M., Kajiwara, N., Honde, N., Shigeta, Y. Aldose reductase inhibition prevents glucose-induced overproduction of type IV collagen in cultured mesangial cells. J Amer Soc Nephrol 1991, 2(3): 293.
-
(1991)
J Amer Soc Nephrol
, vol.2
, Issue.3
, pp. 293
-
-
Kikkawa, R.1
Haneda, M.2
Kajiwara, N.3
Honde, N.4
Shigeta, Y.5
-
7
-
-
0026657444
-
Effects of a newaldose reductase inhibitor, (2S,4S)-6-fluoro-2′,5′-dioxospiro[chroman - 4,4′ - imidazolidine] - 2 - carboxamide (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozotocin-induced diabetic rats
-
Mizuno, K., Kato, N., Matsubara, A., Nakano, K., Kurono, M. Effects of a newaldose reductase inhibitor, (2S,4S)-6-fluoro-2′,5′-dioxospiro[chroman - 4,4′ - imidazolidine] - 2 - carboxamide (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozotocin-induced diabetic rats. Metabolism 1992, 41: 1081-6.
-
(1992)
Metabolism
, vol.41
, pp. 1081-1086
-
-
Mizuno, K.1
Kato, N.2
Matsubara, A.3
Nakano, K.4
Kurono, M.5
-
8
-
-
0027373116
-
The preventive effect of aldose reductase inhibitor, SNK-860, on diabetic somatic and autonomic neuropathy in streptozotocin-induced diabetic rat
-
Yamada, H., Hotta, N , Nakamura, J. et al. The preventive effect of aldose reductase inhibitor, SNK-860, on diabetic somatic and autonomic neuropathy in streptozotocin-induced diabetic rat. J Jpn Diabetes Soc 1993, 36 693-700.
-
(1993)
J Jpn Diabetes Soc
, vol.36
, pp. 693-700
-
-
Yamada, H.1
Hotta, N.2
Nakamura, J.3
-
9
-
-
0027673649
-
Effects of an aldose reductase inhibitor, SNK-860, on the histopathological changes of refinal tissues in a streptozotocin-induced diabetic rat model
-
Akita, M., Mizuno, K., Matsubara, A., Nakano, K., Kurono, M. Effects of an aldose reductase inhibitor, SNK-860, on the histopathological changes of refinal tissues in a streptozotocin-induced diabetic rat model. Acta Med Okayama 1993, 47: 299-304.
-
(1993)
Acta Med Okayama
, vol.47
, pp. 299-304
-
-
Akita, M.1
Mizuno, K.2
Matsubara, A.3
Nakano, K.4
Kurono, M.5
-
10
-
-
0028035456
-
Effect of long-term treatment with a new aldose reductase inhibitor, (2S,4S)-6-fluoro-2′,5′-dioxospiro-[chroman-4,4′-imidazolidine] -2 -carboxamide (SNK-860), on peripheral neuropathy in streptozotocin-induced diabetic rats
-
Kato, N., Mizuno, K., Matsubara, A., Nakano, K., Kurono, M., Yagihashi, S. Effect of long-term treatment with a new aldose reductase inhibitor, (2S,4S)-6-fluoro-2′,5′-dioxospiro-[chroman-4,4′-imidazolidine] -2 -carboxamide (SNK-860), on peripheral neuropathy in streptozotocin-induced diabetic rats. J Diabetes Complications 1994, 8: 27-32.
-
(1994)
J Diabetes Complications
, vol.8
, pp. 27-32
-
-
Kato, N.1
Mizuno, K.2
Matsubara, A.3
Nakano, K.4
Kurono, M.5
Yagihashi, S.6
-
11
-
-
15844369445
-
-
Compsns containing aldose reductase inhibitors for the treatment of ulcers. EP 437025
-
Sawai, K., Kuroni, M., Nakano, K., Sato, M., Kuboyama, N., Ito, T., Kondo, Y. (Sanwa Kagaku Kenkyusho Co., Ltd.) Compsns containing aldose reductase inhibitors for the treatment of ulcers. EP 437025.
-
-
-
Sawai, K.1
Kuroni, M.2
Nakano, K.3
Sato, M.4
Kuboyama, N.5
Ito, T.6
Kondo, Y.7
-
12
-
-
0342934489
-
-
March
-
Sanwa Kagaku Kenkyusho Co , Ltd. Company Brochure 1995, March.
-
(1995)
Company Brochure
-
-
-
17
-
-
15844425867
-
M-16209
-
M-16209. Annu Drug Data Report 1991, 13: 406.
-
(1991)
Annu Drug Data Report
, vol.13
, pp. 406
-
-
-
18
-
-
15844381611
-
SNK-860
-
SNK-860. Annu Drug Data Report 1993, 15: 748.
-
(1993)
Annu Drug Data Report
, vol.15
, pp. 748
-
-
-
20
-
-
15844388126
-
WP-921
-
WP-921. Annu Drug Data Report 1994, 16: 559.
-
(1994)
Annu Drug Data Report
, vol.16
, pp. 559
-
-
-
22
-
-
0028898267
-
Zopolrestat
-
Prous, J., Mealy, N., Castañer, J. Zopolrestat. Drugs Fut 1995, 20: 33-6.
-
(1995)
Drugs Fut
, vol.20
, pp. 33-36
-
-
Prous, J.1
Mealy, N.2
Castañer, J.3
-
23
-
-
15844404766
-
Study on the synthesis of aldose reductase inhibitors (No. 5). Synthesis and activity of optically active hydantoin derivatives
-
(March 29-31, Osaka) Abst 30CC 11-3
-
Kaino, R , Yamaguchi, T., Usui, T., Fukushima, M., Mizuno, K., Baba, Y., Kurono, M. Study on the synthesis of aldose reductase inhibitors (No. 5). Synthesis and activity of optically active hydantoin derivatives. 113th Annu Meet Pharmaceut Soc Jpn (March 29-31, Osaka) 1993, Abst 30CC 11-3.
-
(1993)
113th Annu Meet Pharmaceut Soc Jpn
-
-
Kaino, R.1
Yamaguchi, T.2
Usui, T.3
Fukushima, M.4
Mizuno, K.5
Baba, Y.6
Kurono, M.7
-
24
-
-
15844397299
-
Sample method for the determination of aldose reductase and activity of the new inhibitory agent SNK-860
-
(March 28-30, Tokyo) Abst 29V 3-046
-
Yamaguchi, T., Tomiya, N., Awaya, T., Kurono, M. Sample method for the determination of aldose reductase and activity of the new inhibitory agent SNK-860. 111th Annu Meet Pharmaceut Soc Jpn (March 28-30, Tokyo) 1991, Abst 29V 3-046.
-
(1991)
111th Annu Meet Pharmaceut Soc Jpn
-
-
Yamaguchi, T.1
Tomiya, N.2
Awaya, T.3
Kurono, M.4
-
25
-
-
34347274668
-
Effect of a new AR inhibitor SNK-860 on autonomic nervous system diseases in STZ diabetic rats
-
Abst H 220
-
Yamada, H., Honta, Y., Ko, N , Sakakibara, F., Nakamura, J., Komori, T., Mori, K., Naruse, K., Nakajima, E., Sakamoto, N. Effect of a new AR inhibitor SNK-860 on autonomic nervous system diseases in STZ diabetic rats. J Jpn Diabetes Soc 1992, 35(Suppl.1): Abst H 220.
-
(1992)
J Jpn Diabetes Soc
, vol.35
, Issue.1 SUPPL.
-
-
Yamada, H.1
Honta, Y.2
Ko, N.3
Sakakibara, F.4
Nakamura, J.5
Komori, T.6
Mori, K.7
Naruse, K.8
Nakajima, E.9
Sakamoto, N.10
-
26
-
-
15844413428
-
Effect of a novel AR inhibitor, SNK-860 and tisssue selectivity - Comparison with MNCV and ERG
-
Abst G 313
-
Horita, Y., Tsunoda, H., Fukazawa, H., Ko, N., Sakakibara, F., Sakamoto, N., Mizuno, K., Kato, N., Kurono, M Effect of a novel AR inhibitor, SNK-860 and tisssue selectivity - Comparison with MNCV and ERG. J Jpn Diabetes Soc 1991, 34(Suppl. 1): Abst G 313.
-
(1991)
J Jpn Diabetes Soc
, vol.34
, Issue.1 SUPPL.
-
-
Horita, Y.1
Tsunoda, H.2
Fukazawa, H.3
Ko, N.4
Sakakibara, F.5
Sakamoto, N.6
Mizuno, K.7
Kato, N.8
Kurono, M.9
-
27
-
-
15844365904
-
Effect of continuous long-term administration of a novel aldose reductase inhibitor, SNK-860 on autonomic nervous system injury in experimentally induced diabetes in rats
-
Abst P3 250
-
Kato, N., Matsubara, A., Mizuno, K., Nakano, M , Kurono, M., Yagihashi, S. Effect of continuous long-term administration of a novel aldose reductase inhibitor, SNK-860 on autonomic nervous system injury in experimentally induced diabetes in rats. J Jpn Diabetes Soc 1991, 34(Suppl. 1): Abst P3 250.
-
(1991)
J Jpn Diabetes Soc
, vol.34
, Issue.1 SUPPL.
-
-
Kato, N.1
Matsubara, A.2
Mizuno, K.3
Nakano, M.4
Kurono, M.5
Yagihashi, S.6
-
28
-
-
85007980900
-
Impairment of peroxidase-dependent degradation of hydrogen peroxide and cell injury in endothelial cells cultured in high glucose media
-
Asahina, T., Kashiwagi, A., Ikebuchi, M , Kida, Y., Ogawa, T., Tanaka, Y., Kikkawa, R., Shigeta, Y Impairment of peroxidase-dependent degradation of hydrogen peroxide and cell injury in endothelial cells cultured in high glucose media. J Jpn Diabetes Soc 1991, 34: 593-8.
-
(1991)
J Jpn Diabetes Soc
, vol.34
, pp. 593-598
-
-
Asahina, T.1
Kashiwagi, A.2
Ikebuchi, M.3
Kida, Y.4
Ogawa, T.5
Tanaka, Y.6
Kikkawa, R.7
Shigeta, Y.8
-
29
-
-
15844397667
-
Effects of AR inhibitor (SNK-860) on platelet aggregation acceleration and decline in erythrocyte transformation in rabbits with diabetes
-
Mizuno, K., Tokunaga, T., Nagano, H., Suzuki, T. Effects of AR inhibitor (SNK-860) on platelet aggregation acceleration and decline in erythrocyte transformation in rabbits with diabetes. J Jpn Diabetes Soc 1995, 38(Suppl. 1): 303.
-
(1995)
J Jpn Diabetes Soc
, vol.38
, Issue.1 SUPPL.
, pp. 303
-
-
Mizuno, K.1
Tokunaga, T.2
Nagano, H.3
Suzuki, T.4
|