Intravenous Propafenone: Efficacy and Safety in the Conversion to Sinus Rhythm of Recent Onset Atrial Fibrillation - A Single-Blind Placebo-Controlled Study

Cardiovascular Drugs and Therapy

Volumn 10, Issue 2, 1996, Pages 153-157

  Bellandi, Francesco ^a,c   Dabizzi, Roberta Piero ^b   Cantini, Fabrizio ^a   Di Natale, Massimo ^a   Niccoli, Laura ^c  

^a MISERICORDIA E DOLCE HOSPITAL   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c NONE

Author keywords

Antiarrhythmic agents; Atrial fibrillation; Propafenone

Indexed keywords

ANTIARRHYTHMIC AGENT; PROPAFENONE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERANCE; FEMALE; HEADACHE; HEART ATRIUM FIBRILLATION; HEART RATE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SINUS RHYTHM; TIME; VERTIGO;

ADULT; AGED; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; PROPAFENONE; SINGLE-BLIND METHOD; TIME FACTORS; TREATMENT OUTCOME;

EID: 0030014885     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00823593     Document Type: Article

References (34)

1. DeSilva RA, Graboys TB, Podrid PJ, Lown B. Cardioversion and defibrillation. Am Heart J 1980;100:881-895.
2. Bazett HC. An analysis of the time-relation of electrocardiograms. Heart 1920;7:353-370.
3. Bryson HM, Palmer KJ, Langtry HD, Fitton A. Propafenone. A reappraisal of its pharmacology, pharmacokinetics and therapeutic use in cardiac arrhythmias. Drugs 1993;45: 85-130.
4. Schlepper M. Propafenone, a review of its profile. Eur Heart J 1987;8(Suppl A):27-32.
5. Wang J, Bourne GW, Wang Z, Villemaire C, Talajic M, Nattel S. Comparative mechanisms of antiarrhythmic drug action in experimental atrial fibrillation. Importance of use-dependent effects of refractoriness. Circulation 1993;88: 1030-1044.
6. Wang ZG, Pellettier LC, Talajic M, Nattel S. Effects of flecainide and quinidine on human atrial action potentials. Role of rate-dependence and comparison with guinea pig, rabbit and dog tissues. Circulation 1990;82:274-283.
7. Capucci A, Gubelli S, Carini G, Fabretti L, Magnani B. Pharmacologic cardioversion with propafenone of stable atrial fibrillation of recent onset. G Ital Cardiol 1987;17: 975-982.
8. Bianconi L. Boccadamo R, Pappalardo A, Gentili C, Pistolese M. Effectiveness of intravenous propafenone for conversion of atrial fibrillation and flutter of recent onset. Am J Cardiol 1989;64:335-338.
9. Bracchetti D, Palmieri M. Safety and effectiveness of intravenous propafenone in cardioversion of recent onset atrial fibrillation. G Ital Cardiol 1992;22(Suppl 1):186.
10. Hamill SC, McLaran CJ, Wood DL, Osborn MJ, Gersh BJ, Holmes DR. Double-blind study of intravenous propafenone for paroxysmal superventricular reentrant tachycardia. J Am Coll Cardiol 1987;9:1364-1368.
11. Assay ME. Atrial fibrillation. In: Rakel RE, ed. Conn's Current Therapy. Philadelphia: WB Saunders, 1988:193.
12. Blazing MA, Morris JJ. Atrial fibrillation: Conventional wisdom reappraised. Heart Dis Stroke 1992;1:78-84.
13. Cowan JC. Antiarrhythmic drugs in the management of atrial fibrillation. Br Heart J 1993;70:304-306.
14. Clark A, Cotter L. Cardioversion in atrial fibrillation. Br J Hosp Med 1993;49:256-261.
15. Weiner P, Bassan MM, Jarchowsky J, Iusin S, Plavnick I. Clinical course of acute fibrillation treated with rapid digitalization. Am Heart J 1983;105:223-227.
16. Falk RH, Knowlton AA, Bernard SA, Gotlieb NE, Battinelli NJ. Digoxin for converting recent-onset atrial fibrillation to sinus rhythm. A randomized double-blind trial. Ann Intern Med 1987;106:503-506.
17. Tommaso C, McDonough T, Parker M, Talano JV. Atrial fibrillation and nutter: Immediate control and conversion with intravenously administered verapamil. Arch Intern Med 1983;143:877-881.
18. Shenasa M, Kus T, Fromer M, LeBlanc RA, Dubuc M, Nadeau R. Effect of intravenous and oral calcium antagonists (diltiazem and verapamil) on sustenance of atrial fibrillation. Am J Cardiol 1988;62:403-407.
19. Kingma JH, Suttorp MJ. Acute pharmacologic conversion of atrial fibrillation and flutter: The role of flecainide, propafenone, and verapamil. Am J Cardiol 1992;70:56A-60A.
20. Hurst JW, Paulk EA, Proctor HD, Schlant RC. Management of patients with atrial fibrillation. Am J Med 1964;37: 728-741.
21. Pascale LR, Bernstein LM, Schoolman H, Foley EF. Intravenous procainamide in the treatment of cardiac arrhythmias. Am Heart J 1954;48:110-122.
22. Fenster PE, Comess KA, Marsh R, Katzemberg C, Hager WD. Conversion of atrial fibrillation to sinus rhythm by acute intravenous procainamide infusion. Am Heart J 1983; 106:501-504.
23. Gavaghan TP, Fenely MP, Campbell TJ, Morgan JJ. Atrial tachyarrhythmias after cardiac surgery: Results of disopyramide therapy. Aust N Z J Med 1985;15:27-32.
24. Faniel R, Shoenfeld PH. Efficacy of intravenous amioarone in converting rapid atrial fibrillation and flutter to sinus rhythm in intensive care patients. Eur Heart J 1983;4: 180-185.
25. Strasberg B, Arditti A, Sclarowsky S, Lewin RF, Buimovici B, Agmon J. Efficacy of intravenous amiodarone in the management of paroxysmal or new atrial fibrillation with fast ventricular response. Int J. Cardiol 1985;7:47-55.
26. Holmes B, Heel RC. Flecainide: A preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs 1985;29:1-33.
27. Donovan KD, Dobb GJ, Coombs LJ, Weekes JN, Murdock CJ, Clarke GM. Reversion of recent-onset atrial fibrillation to sinus rhythm by intravenous flecainide. Am J Cardiol 1991;67:137-141.
28. Suttorp, MJ, Kingma JH, Jessurun ER, Lie-A-Huen L, van Hemel NM, Lie KI. The value of class IC antiarrhythmic drugs for acute conversion of paroxysmal atrial fibrillation or nutter to sinus rhythm. J Am Coll Cardiol 1990;16: 1722-1727.
29. Murdock CJ, Kyles AE, Yeung-Lai-Wah JA, Qi A, Vorderbrugge S, Kerr CR. Atrial flutter in patients treated for atrial fibrillation with propafenone. Am J Cardiol 1990;66: 755-757.
30. Van Gelder IC, Crijns HJ, Van Gust WH, De Langen CD, Van Wijk LM, Lie KI. Effects of flecainide on the atrial defibrillation threshold. Am J Cardiol 1989;63:112-114.
31. Bertini G, Conti A, Fradella G, et al. Propafenone verus amiodarone in field treatment of primary atrial tachydysrhythmias. Emerg Med 1990;8:15-20.
32. Connolly SJ, Mulji AS, Hoffert DL, Davis C, Shregge BW. Randomized placebo-controlled trial of propafenone for treatment of atrial tachyarrhythmias after cardiac surgery. J Am Coll Cardiol 1987;10:1145-1148.
33. Gentili C, Giordano F, Alois A, Massa E, Bianconi L. Efficacy of intravenous propafenone in acute atrial fibrillation complicating open-heart surgery. Am Heart J 1992;123: 1225-1228.
34. Goy JJ, Kaufman U, Kappenberger L, Sigwart U. Restoration of sinus rhythm with flecainide in patients with atrial fibrillation. Am J Cardiol 1988;62:38D-40D.