Microspheres based detoxification system: A new method in convective blood purification

Artificial Organs

Volumn 20, Issue 5, 1996, Pages 420-425

  Von Appen, Kai ^a   Weber, Christoph ^b   Losert, Udo ^c   Schima, Heinrich ^c   Gurland, Hans Jürgen ^a   Falkenhagen, Dieter ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b DANUBE UNIVERSITY KREMS   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

adsorption; bacterial toxins; cytokines; microspheres; plasma detoxification; protein binding; sepsis; toxicology

Indexed keywords

BIOCHEMISTRY; BLOOD; DETOXIFICATION; DIALYSIS; EFFICIENCY; HEMODIALYZERS; MICROSPHERES; PROTEINS;

ADSORBERS; BACTERIAL TOXIN; BLOOD PURIFICATION; CYTOKINES; HAEMODIALYSIS; HYDROPHOBICS; PLASMA DETOXIFICATION; PROTEIN-BINDING; SEPSIS; TOXICOLOGY;

ADSORPTION;

BACTERIAL TOXIN; CYTOKINE; MICROSPHERE;

CONFERENCE PAPER; DETOXIFICATION; HEMODIALYSIS; HEMOFILTRATION; HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SEPSIS;

EID: 0030014812     PISSN: 0160564X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1525-1594.1996.tb04526.x     Document Type: Conference Paper

References (13)

1. Falkenhagen D, Brown GS, Winkler R, Holtz M, Möhrke T, Schneidewind J, Mietzner S, Behm E, Palm M, Loth F, Klinkmann H. Possibilities of selective and unselective adsorbent development in blood purification. In: Klinkmann H, Smeby L, eds. Terminal renal failure: therapeutic problems, possibilities, and potentials. Maastricht, The Netherlands: S. Karger, 1990:142-56. (Berlyne GM, Giovannetti S, eds. Contributions to nephrology; vol 78).
2. Falkenhagen D, Weber C, Schima H, Loth F, Rajnoch C, Vogt G, Moser H, Mitzner S. Eine neue Technologie der simultanen Filtration/Adsorption auf der Basis einer High-Speed-Rezirkulation von Nano- und Microspheres für die extrakorporale Blutreinigung. Biomed Tech (Berlin) 1994;39: (Suppl):105-8.
3. Falkenhagen D. Small particles in medicine. Artif Organs 1995;19(8):792-4.
4. Falkenhagen D. Patent: Arrangement for removing substances from liquids, in particular blood (International Patent Publications No. WO 95/04559). International Patent Classification: A61M 1/34, 1994.
5. Falkenhagen D, Weber C, Loth F, Schima H, Paul D, Rajnoch C, Mitzner S. A newly developed endotoxin (ET) removal system based on a simultaneous filtration/adsorption technology (abstract). In: Leunissen KML, ed. 12th Annual Meeting of the International Society of Blood Purification. Maastricht, The Netherlands: S. Karger, 1994:173.
6. Falkenhagen D, Mitzner S, Loth J, Courtney JM, Klinkmann H. Endotoxin removal by polymeric adsorbents - potential application in medicine. 7th International Conference on Polymers in Medicine and Surgery, Noordwijkerhout, The Netherlands, September 1-3, 1993; 212-5.
7. Stange J, Mitzner S, Ramlow W, Gliesche T, Hickstein H, Schmidt R. A new procedure for the removal of protein bound drugs and toxins. ASAIO J 1993;Suppl:M621-M625.
8. Weber C, Rajnoch C, Loth F, Schima H, Falkenhagen D. The microspheres based detoxification system (MDS). Artif Organs 1994;17:595-602.
9. Wendel A. Reactive oxygen species, antiproteases, and cytokines in sepsis. Klin Wochenschr 1991;69:969-74.
10. Parrillo JE. Pathogenic mechanisms of septic shock. N Engl J Med 1993;328:1471-7.
11. Kodama M, Aoki H, Tani T, Hanasawa K. Hemoperfusion using a polymyxin B immobilized fiber column for the removal of endotoxin. In: Levin J, Alving CR, Munford RS, Stütz PL, eds. Bacterial endotoxin: recognition and effector mechanisms. Amsterdam Elsevier, 1993:389-98.
12. Christ WJ, Asano O, Robidoux ALC, Perez M, Wang Y, Dubuc GR, Gavin WE, Hawkins LD, McGuiness PD, Mullarkay MA, Lewis MD, Kishi Y, Kawata T, Bristol JR, Rose JR, Rossignol DP, Kobayashi S, Hishinuma I, A. K. Asakawa N, Katayama K, Yamatsu I. E5531, a pure endotoxin antagonist of high potency. Science 1995;268:80-3.
13. Weber C, Linsberger I, Rafiee-Tehrani M, Falkenhagen D. Permeability and adsorption capacity of dialysis membranes to lipid A. ASAIO J 1995:(in press).