Modulation of the pharmacokinetics of 5′-deoxy-5-fluorouridine and 5-fluorouracil in rats by oral co-administration of acyclothymidine

Biological and Pharmaceutical Bulletin

Volumn 19, Issue 5, 1996, Pages 729-732

  Hamada, Akinobu ^a   Fukushima, Shoji ^a,b   Saneyoshi, Mineo ^c   Shimizu, Satoshi ^d   Kawaguchi, Takeo ^d   Nakano, Masahiro ^a  

^a KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

^c Nishi Tokyo University   (Japan)

^d JOSAI UNIVERSITY   (Japan)

Author keywords

5 fluorouracil; 5 deoxy 5 fluorouridine; Acyclothymidine; Pyrimidine nucleoside phosphorylase

Indexed keywords

ACYCLOTHYMIDINE; DOXIFLURIDINE; ENZYME INHIBITOR; FLUOROURACIL; PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE;

ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG INHIBITION; GASTROINTESTINAL TOXICITY; LIVER HOMOGENATE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG INTERACTIONS; ENZYME INHIBITORS; FLOXURIDINE; FLUOROURACIL; INTESTINES; LIVER; MALE; PENTOSYLTRANSFERASES; RATS; URACIL;

EID: 0030014226     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.19.729     Document Type: Article

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