Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex

Immunopharmacology

Volumn 32, Issue 1-3, 1996, Pages 99-101

  Bompart, Guy ^a   Tack, Ivan ^a   Castaño, Encarna Marin ^a   Pesquero, João Bosco ^b   Girolami, Jean Pierre ^a   Bascands, Jean Loup ^a  

^a CHU RANGUEIL   (France)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Bradykinin B2 receptor; Cyclosporine A; Kallikrein; Kidney; mRNA

Indexed keywords

BRADYKININ B2 RECEPTOR; CYCLOSPORIN A; KALLIKREIN; MESSENGER RNA;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; HEMODYNAMICS; KIDNEY CORTEX; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030014183     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/0162-3109(95)00063-1     Document Type: Conference Paper

References (6)

1. Bascands JL, Marin Castaño ME, Bompart G, Pecher C, Gaucher M, Girolami JP. Post-natal maturation of the kallikrein kinin system in the rat kidney: from enzyme activity to receptor gene expression. J. Am. Soc. Nephrol., in press.
2. Begley DJ, Squires B, Zlokovic V, Mitrovic DM, Hughes CCW, Revest PA, Greenwood J. Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A. J. Neurochem. 1990, 55, 1222-1230.
3. Martinez L, Vio CP, Valdés G, Kychenthal W, Mendoza S. Decreased kallikrein excretion in renal transplant treated with cyclosporine A. Transpl. Proc. 1990; 22: 294-296.
4. Pesquero JB, Lindsey CJ, Zeh K, Paiva ACM, Ganten D, Bader M. Molecular structure and expression of rat bradykinin B2 receptor gene. J. Biol. Chem. 1994; 43: 26920-26925.
5. Spragg J, Winblatt ME, Coblyn J, Fraser P, Austen KF. Effect of cyclosporine on urinary kallikrein excretion in patients with rheumatoid arthritis. J. Lab. Clin. Med. 1988; 112: 324-332.
6. Sturrock NDC, Struthers AD. Hormonal and other mechanisms involved in the pathogenesis of cyclosporin-induced nephro-toxicity and hypertension in man. Clin. Sci. 1994; 86: 1-9.