Intracellularly applied anti-P70 antibody blocks the induction of abnormal membrane properties by pentylenetetrazole in identified Euhadra neurons

Brain Research

Volumn 716, Issue 1-2, 1996, Pages 187-191

  Onozuka, Minoru ^a   Watanabe, Kazuko ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

anti P70 antibody; bursting activity; Euhadra neuron; negative slope resistance; P70; potassium current

Indexed keywords

ANTIBODY; CONVULSANT AGENT; PENTETRAZOLE; PROTEIN P70; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EPILEPSY; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SNAIL; VOLTAGE CLAMP;

EID: 0030013989     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00016-9     Document Type: Article

References (29)

1. David, R.J., Wilson, W.A. and Escueta, A.V., Voltage clamp analysis of pentylenetetrazol effects on Aplysia neurons, Brain Res., 67 (1974) 549-554.
2. Delgard-Escueta, A.V., Ward, A.A., Woodbury, D.M. and Porter, R.J., New wave of research in the epilepsies, Adv. Neurol., 44 (1986) 435-464.
3. Gainer, H., Patterns of protein synthesis in individual, identified molluscan neurons, Brain Res., 39 (1972) 369-385.
4. Gainer, H., Effects of experimentally induced dispause on the electrophysiology and protein synthesis patterns of identified molluscan neurons, Brain Res., 39 (1972) 387-402.
5. Klee, M.R., Faber, D.S. and Heiss, W.D., Strychnine and pentylenetetrazole-induced changes of excitability in Aplysia neurons, Science, 179 (1973) 1133-1136.
6. Matsumoto, H., Intracellular events during the activation of cortical epileptiform discharges, Electroencephalogr. Clin. Neurophysiol., 17 (1964) 294-307.
7. Morgan, J.I., Cohen, D.R., Hempstead, J.L. and Curran, T., Mapping patterns of c-fos expression in the central nervous system after seizure, Science, 237 (1987) 192-197.
8. Onozuka, M., Furuichi, H. and Fukami, Y., Cyclic AMP-dependent protein phosphorylation is involved in the development of negative slope resistance and a reduction of the potassium current induced by pentylenetetrazole in identified snail neurons, Neurosci. Lett., 123 (1991) 257-260.
9. Onozuka, M., Furuichi, H., Imai, S. and Ozono, S., Activation process of calcium-dependent potassium channel in Euhadra neurons: involvement of calcium/calmodulin and subsequent protein phosphorylation, Comp. Biochem. Physiol., 99A (1991) 419-428.
10. Onozuka, M. and Imai, S., Induction of epileptic seizure activity by a specific protein from cobalt-induced epileptogenic cortex of rats, Brain Res., 507 (1990) 143-145.
11. Onozuka, M., Imai, S., Furuichi, H. and Ozono, S., A specific 70K protein found in epileptic rat cortex: induction of bursting activity and negative resistance by its intracellular application in Euchadra neurons, J. Neurobiol., 22 (1991) 287-297.
12. Onozuka, M., Imai, S. and Ozono, S., The 70-kDa epileptic cortical protein elicits bursting activity accompanied by a reduction of outward current in Euhadra neurons which is inhibited by an antibody against this protein, Brain Res., 531 (1990) 276-279.
13. Onozuka, M., Imai, S., Ozono, S., Isobe, T., Okuyama, T., Takano, S., Sugimura, Y. and Fukami,Y., A novel protein induced in cortical epileptic focus of rat cerebrum: a possible linkage to epileptogenesis, Exp. Neurol., 111 (1991) 190-197.
14. Onozuka, M., Imai, S., Ozono, S. and Sugimura, Y., A specific 70 kDa protein induced in the epileptogenic cortex of rats elicits bursting activity and inactivation of potassium current in snail neurons, Neurosci. Lett., 115 (1990) 49-54.
15. Onozuka, M., Imai, S. and Sugaya, E., Pentylenetetrazole-induced bursting activity and cellular protein phosphorylation in snail neurons, Brain Res., 362 (1986) 33-39.
16. Onozuka, M., Kubo, K. and Ozono, S., The molecular mechanism underlying pentylenetetrazole-induced bursting activity in Euhadra neurons: involvement of protein phosphorylation, Comp. Biochem. Physiol., 100C (1991) 423-432.
17. 2+/calmodulin-dependent protein phosphorylation, Neurosci. Res., 11 (1991) 146-153.
18. Pellmar, T.C. and Wilson, W.A., Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance, Science, 197 (1977) 912-914.
19. Prince, D.A., Neurophysiology of epilepsy, Annu. Rev. Neurosci., 1 (1978) 395-415.
20. Rockson, S., Stone, R., Weyden, M. and Kelley, W.N., Negative resistance characteristic essential for the maintenance of slow oscillations in bursting neurons. Science, 186 (1974) 932-934.
21. Saffen, D.W., Cole, A.J., Worley, P.F., Christey, B.A., Ryeder, K. and Baraban, J.M., Convulsant-induced increase in transcription factor messenger RNAs in rat brain, Proc. Natl. Acad. USA, 85 (1988) 7795-7799.
22. Sugaya, E. and Onozuka, M., Intracellular calcium: its movement during pentylenetetrazole-induced bursting activity, Science, 200 (1978) 297-299.
23. Sugaya, E. and Onozuka, M., Intracellular calcium: its release from granules during bursting activity in snail neurons, Science, 202 (1978) 1195-1197.
24. Sugaya, E. and Onozuka, M., Ion shower milling: its application to cell membrane removal, Science, 202 (1978) 1197-1198.
25. Sugaya, E., Onozuka, M., Furuichi, H., Kishii, K. and Sugaya, A., Effect of phenytoin on intracellular calcium and intracellular protein changes during pentylenetetrazole-induced bursting activity in snail neurons, Brain Res., 327 (1985) 161-168.
26. Sugaya, E., Onozuka, M., Kishii, K., Sugaya, A. and Tsuda, T., Intracellular protein changes during pentylenetetrazole- induced bursting activity in snail neurons, Brain Res., 253 (1982) 271-279.
27. Sugaya, A., Sugaya, E. and Tsujitani, M., Pentylenetetrazol-induced intracellular potential changes of the neuron of the Japanese land snail Euhadra peliomphala, Jpn. J. Physiol., 23 (1973) 261-274.
28. Williamson, T.L. and Crill, W.E., The effects of pentylenetetrazol on molluscan neurons. I. Intracellular recording and stimulation, Brain Res., 116 (1976) 217-229.
29. Woodbury, D.M., Convulsant drugs: mechanisms of action, Adv. Neurol., 27 (1980) 249-303.