Feasibility of labeled α-acetamido-aminoisobutyric acid as new tracer compound for kinetic labeling of neutral amino acid transport: Preparation of α-(N-[1-11C]acetyl)- and α-(N-[1-14C]acetyl)-aminoisobutyric acid

Nuclear Medicine and Biology

Volumn 23, Issue 3, 1996, Pages 359-363

  Prenant, Christian ^a   Theobald, Annemarie ^a   Haberkorn, Uwe ^a   Bellemann, Matthias E ^a   Weber, Klaus ^a   Oberdorfer, Franz ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Acetamido aminoisobutyric acid; Amino acid transport; PET

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; ALPHA ACETAMIDO AMINOISOBUTYRIC ACID; CARBON 11; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; POSITRON EMISSION TOMOGRAPHY; RAT; TUMOR CELL CULTURE;

ADENOCARCINOMA; AMINO ACIDS; AMINOBUTYRIC ACIDS; ANIMALS; BIOLOGICAL TRANSPORT; CARBON RADIOISOTOPES; CELL LINE; FEASIBILITY STUDIES; INDICATORS AND REAGENTS; ISOTOPE LABELING; KINETICS; MALE; PROSTATIC NEOPLASMS; RATS; TIME FACTORS; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED; TUMOR CELLS, CULTURED;

EID: 0030013983     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/0969-8051(96)00016-9     Document Type: Article

References (19)

1. Appelgren L.-E., Lindqvist I., Nilsson O. and Ronquist G. (1982) Distribution of some non-physiological amino acids (AIB, DAB, MeAIB) in mice. Acta Physiol. Scand. 115, 261-268.
2. Boerner P. and Saier M.H. (1985) Adaptive regulatory control of system A transport activity in a kidney epithelial cell line and in a transformed variant. J. Cell. Physiol 122, 308-315.
3. Christensen H.N., Cespedes C.D., Handlogten M.E. and Ronquist G. (1973) Energization of amino acid transport, studied for the Ehrlich ascites tumor cell. Biochim. Biophys. Acta 300, 487-522.
4. Collarini E.J. and Oxender D.L. (1987) Mechanisms of transport of amino acids across membranes. Annu. Rev. Nutr. 7, 75-90.
5. Conti P.S., Sordillo E.M., Sordillo P.P. and Schmall B. (1985) Tumor localization of alpha-aminoisobutyric acid (AIB) in human melanoma heterotransplants. Eur. J. Nucl. Med. 10, 45-47.
6. 11C in normal and prostate cancer-bearing fat after chemotherapy. Eur. J. Nucl. Med. 6, 535-538.
7. Isselbacher K.J. (1972) Increased uptake of amino acids and 2-deoxy-D-glucose by virus-transformed cells in culture. Proc. Natl. Acad. Sci. USA 69, 585-589.
8. Johnstone R.M. and Scholefield P.G. (1965) Amino acid transport in tumor cells. Adv. Cancer Res. 9, 143-226.
9. 11C]melatonin. Appl. Radiat. Isot. 38, 1073-1077.
10. 11C]acid chlorides as labelling agents. Appl. Radiat. Isot. 41, 471-476.
11. Nakamura K.D., Weber M.J. (1979) Amino acid transport in normal and Rous sarcoma virus-transformed chicken embryo fibroblasts. J. Cell. Physiol. 99, 15-22.
12. 11C]-acetyl)cysteinyl-7,9-trans-11,14-cis-eicosatetraenoic acid. J. Labelled Compd. Radiopharm. 31, 903-913.
13. 11C]aminoisobutyric acid from an azadisilodine derivative of alanine. J. Labelled Compd. Radiopharm. 33, 345-353.
14. Oxender D.L. and Christensen H.N. (1963) Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cell. J. Biol. Chem. 238, 3686-3699.
15. Saier M.H., Daneils G.A., Boerner P. and Lin J. (1988) Neutral amino acid transport systems in animal cells: Potential targets of oncogene action and regulators of cellular growth. J. Membr. Biol. 104, 1-20.
16. Scanlon K.J., Safirstein R.L., Thies H., Gross R.B., Waxman S. and Guttenplan J.B. (1983) Inhibition of amino acid transport by cis-diamminedichloroplatinum(II) derivatives in L1210 murine leukemia cells. Cancer Res. 43, 4211-4215.
17. Schmall B., Conti P.S., Schaeffer D.J. and Kleinert E.L. (1992) Tumor and organ biochemical profiles determined in vivo following uptake of a combination of radiolabelled substrates: Potential applications for PET. Am. J. Physiol. Imaging 7, 2-11.
18. Sordillo P.P., DiResta G.R., Fissekis J., Conti P.S., Benna R.S., Yeh S.D.J. and Laughlin J.S. (1991) Tumor imaging with carbon-11-labeled alpha-aminoisobutyric acid (AIB) in patients with malignant melanoma. Am. J. Physiol. Imaging 6, 172-175.
19. 2-Oxazolinonen-(5) mit Carbon-säureanhydriden/Pyridin. Chem. Ber. 104, 3644-3652.