Prognostic significance of TP53 accumulation in human primary breast cancer: Comparison between a rapid quantitative immunoassay and SSCP analysis

International Journal of Cancer

Volumn 69, Issue 2, 1996, Pages 125-130

  De Witte, Hans H ^a   Foekens, John A ^b   Lennerstrand, Johan ^c   Smid, Marcel ^b   Look, Maxime P ^b   Klijn, Jan G M ^b   Benraad, Theo J ^a   Berns, Els M J J ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c AB Sangtec Medical   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ASSAY; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ADULT; AGED; BREAST NEOPLASMS; EXONS; FEMALE; GENES, P53; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROGNOSIS; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030013978     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960422)69:2<125::AID-IJC10>3.0.CO;2-8     Document Type: Article

References (20)

1. ANDERSON, T.I., HOLM, R., NESLAND, J.M., HEIMDAL, K.R., OTTESTAD, L. and BORRESEN, A.-L., Prognostic significance of TP53 alterations in breast carcinoma. Brit. J Cancer, 68, 540-548 (1993).
2. BANKS, L., MATLASHEWSKI, G. and CRAWFORD, L., Isolation of human TP53-specific monoclonal antibodies and their use in the studies of human TP53 expression. Europ. J. Biochem., 159, 529-534 (1986).
3. BARLOW, R.E., BARTHOLOMEW, D.J., BREMMER, J.M. and BRUNK, H.D., Statistical interference under order restrictions. Wiley, London (1972).
4. BERNS, E.M.J.J., KLUN, J.G.M., VAN PUTTEN, W.L.J., VAN STAVEREN, I.L., PORTENGEN, H. and FOEKENS, J.A., c-myc amplification is a better prognostic factor than HER2/neu amplification in primary breast cancer. Cancer Res., 52, 1107-1113 (1992).
5. BODNER, S.M., MINNA, J.D., JENSEN, S.M., D'AMICO, D., CARBONE, D., MITSUDOMI, T., FEDORKO, J., BUCHHAGEN, D.L., NAU, M.M., GAZDAR, A.F. and LINNOILA, R.L, Expression of mutant TP53 proteins in lung cancer correlates with the class of TP53 gene mutation. Oncogene, 7,743-749(1992).
6. BORG, A., LENNERSTRAND, J., STENMARK-ASKMALM, M., FERNÖ, M., BRISFORS, A., ÖHRVIK, A., STÅL, O., KILLANDER, D., LANE. D. and BRUNDELL, J., Prognostic significance of TP53 overexpression in primary breast cancer, a novel luminometric immunoassay applicable on steroid receptors cytosols. Brit. J. Cancer, 71, 1013-1017 (1995).
7. CHO, Y., GORINA, S., JEFFREY, P.D. and PAVLETICH, N.P., Crystal structure of a TP53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science, 265, 346-355 (1994).
8. ELLEDGE, R.M. and ALLRED, D.C., The TP53 tumor suppressor gene in breast cancer. Breast Cancer Res. Treat, 32,39-47 (1994).
9. GREENBLATT, M.S., BENNETT, W.P., HOLLSTEIN, M. and HARRIS, C.C., Mutations in the TP53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54,4855-4878 (1994).
10. HOLLSTEIN, M., SIDRANSKY, D., VOGELSTEIN, B. and HARRIS, C.C., TP53 mutations in human cancers. Science, 253, 49-53 (1991).
11. KAPLAN, E.L. and MEIER, P., Nonparametric estimation from incomplete observations. J, amer. Stat. Assoc., 53, 457-481 (1958).
12. LANE, D.P., On the expression of the TP53 protein in human cancer. Mol. Biol Rep., 19, 23-29 (1994).
13. LEVINE, A.J., MOMAND, J. and FINLAY, C.A., The TP53 tumour suppressor gene. Nature (Lond.), 352, 453-456 (1991).
14. NIGRO, J.M. and 15 OTHERS, Mutations in the TP53 gene occur in diverse human tumour types. Nature (Lond.), 342, 705-708 (1989).
15. ORITA, M., IWAHAMA, H., KANAZAWA, H., HAYASHI, K. and SEKIYA, T., Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc. nat. Acad. Sci (Wash.), 86, 2766-2770 (1989).
16. OSBORNE, R.J., MERLO, G.R., MITSUDOMI, T., VENESIO, T., LISCLA, D.S., CAPPA, A.P.M., CHIBA, L. TAKAHASHI, T., NAU, M.M., CALLAHAN, R. and MINNA, J.D., Mutations in the TP53 gene in primary human breast cancers. Cancer Res., 51, 6194-6198 (1991).
17. Revision of the standards for the assessment of hormone receptors in human breast cancer: report of the 2nd E.O.R.T.C. workshop, held on 16-17 March, 1979, in The Netherlands Cancer Institute. Europ. J. Cancer, 16, 1513-1515 (1980).
18. RUNNEBAUM, I.B., NAGARAJAN, M., BOWMAN, M., SOTO, D. and SUKUMAR, S., Mutations in TP53 as potential molecular markers for human breast cancer. Proc. nat. Acad. Sci. (Wash.), 88, 10657-10661 (1991).
19. STURZBECHER, H.-W. and DEPPERT, W., The tumor suppressor protein TP53: relationship of structure to function (review). Oncol. Rep., 1, 301-307 (1994).
20. VOJTESEK, B., BÁRTEK, J., MIDGLEY, C.A. and LANE, D.P., An immunochemical analysis of the human nuclear phosphoprotein TP53: new monoclonal antibodies and epitope mapping using recombinant TP53. J. Immunol. Methods, 151, 237-244 (1992).