Estrogen blocks parathyroid hormone (PTH)-stimulated osteoclast-like cell formation by selectively affecting PTH-responsive cyclic adenosine monophosphate pathway

Endocrinology

Volumn 137, Issue 6, 1996, Pages 2217-2224

  Kaji, Hiroshi ^a   Sugimoto, Toshitsugu ^a   Kanatani, Masanori ^a   Nasu, Masamichi ^a   Chihara, Kazuo ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; ESTROGEN; PARATHYROID HORMONE;

ANIMAL CELL; ARTICLE; BLAST CELL; CALCIUM BLOOD LEVEL; CORTICAL BONE; ENZYME INHIBITION; HEMATOPOIETIC CELL; HORMONAL REGULATION; HYPERPARATHYROIDISM; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; OSTEOPENIA; PRIORITY JOURNAL;

EID: 0030013846     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.6.8641168     Document Type: Article

References (37)

1. Tam CS, Heersche JNM, Murray TM, Parsons JA 1982 Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration. Endocrinology 110:506-512
2. Kleerekoper M, Villaneuva AR, Mathews CHE 1983 PTH mediated bone loss in primary, secondary hyperparathyroidism. In: Frame B, Potts JT (eds) Clinical Disorders of Bone and Mineral Metabolism. Excerpta Medica, Amsterdam, pp 200-203
3. Silverberg SJ, Shane E, Cruz LDL, Dempster DW, Feldman F, Seldin D, Jacobs TP, Siris ES, Cafferty M, Parisien MV, Lindsay R, Clemens TL, Bilezikian JP 1989 Skeletal disease in primary hyperparathyroidism. J Bone Miner Res 4:283-291
4. Gallsgher JC, Nordin BEC 1972 Treatment with oestrogens of primary hyperparathyroidism in post-menopausal women. Lancet 1:503-5072
5. Marcus R, Madvig P, Crim M, Pont A, Kosek J 1984 Conjugated estrogens in the treatment of postmenopausal women with hyperparathyroidism. Ann Intern Med 100:633-640
6. Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelberg TC, Riggs BL 1988 Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241:84-86
7. Komm BS, Terpening CM, Benz DJ, Graeme KA, Gallegos A, Korc M, Greene GL, O'Malley BW, Hausler MR 1988 Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science 241:81-83
8. Oursler MJ, Osdoby P, Pyfferoen J, Riggs BL, Spelsberg TC 1991 Avian osteoclasts as estrogen target cells. Proc Natl Acad Sci USA 88:6613-6617
9. Hong MH, Williams H, Jin CH, Pike JW 1994 17β-estradiol suppresses mouse osteoclast differentiation and function in vitro via the estrogen receptor. J Bone Miner Res [Suppl] 9:S161 (Abstract)
10. Oursler MJ, Pederson L, Fitzpatrick L, Riggs L, Spelsberg T 1994 Human giant cell tumors of the bone (osteoblastomas) are estrogen target cells. Proc Natl Acad Sci USA 91:5227-5231
11. Atkins D, Zanelli JM, Peacock M, Nordin BEC 1972 The effect of oestrogens on the response of bone to parathyroid hormone in vitro. J Endocrinol 54:107-117
12. Pilbeam CC, Klein-nulend J, Raisz LG 1989 Inhibition by 17β-estradiol of PTH stimulated resorption and prostaglandin production in cultured neonatal mouse calvariae. Biochem Biophys Res Commun 163:1319-1324
13. Kaji H, Sugimoto T, Kanatani M, Miyauchi A, Kimura T, Sakakibara S, Fukase M, Chihara K 1994 Carboxyl-terminal parathyroid hormone fragments stimulate osteoclast-like cell formation and osteoclastic activity. Endocrinology 134:1897-1904
14. Hakeda Y, Hiura K, Sato T, Okazaki R, Matsumoto T, Ogata E, Ishitani R, Kumegawa M 1989 Existence of parathyroid hormone binding sites on murine hemopoietic blast cells. Biochem Biophys Res Commun 163:1481-1486
15. Kaji H, Sugimoto T, Kanatani M, Fukase M, Chihara K 1995 Carboxyl-terminal peptides from parathyroid hormone-related protein stimulate osteoclast-like cell formation. Endocrinology 136:842-848
16. Kaji H, Sugimoto T, Kanatani M, Fukase M, Chihara K 1993 Involvement of dual signal transduction systems in the stimulation of osteoclast-like cell formation by parathyroid hormone and parathyroid hormone-related peptide. Biochem Biophys Res Commun 194: 157-162
17. Kaji H, Sugimoto T, Kanatani M, Fukase M, Kumegawa M, Chihara K 1995 Retinoic acid induces osteoclast-like cell formation by directly acting on hemopoietic blast cells and stimulates osteopontin mRNA expression in isolated osteoclasts. Life Sci 56:1903-1913
18. 2 stimulates osteoclast-like cell formation and bone-resorbing activity via osteoblasts: role of cAMP-dependent protein kinase. J Bone Miner Res 11:62-71
19. Abou-Samra AB, Juppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT Jr, Kronenberg HM, Segre GV 1992 Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 89:2732-2736
20. Ernst M, Heath JK, Rodan GA 1989 Estradiol effects on proliferation, messenger ribonucleic acid for collagen and insulin-like growth factor-I, and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones. Endocrinology 125:825-833
21. Fukayama S, Tashjian AH Jr 1989 Direct modulation by estradiol of the response of human bone cells (SaOS-2) to human parathyroid hormone (PTH) and PTH-related protein. Endocrinology 124:397-401
22. Takada Y, Kusuda M, Hiura K, Sato T, Mochizuki H, Nagao Y, Tomura M, Yahiro M, Hakeda Y, Kawashima H, Kumegawa M 1992 A simple method to assess osteoclast-mediated bone resorption using unfractionated bone cells. Bone Miner 17:347-359
23. Mochizuki H, Hakeda Y, Wakatsuki N, Usui N, Akashi S, Sato T, Tanaka K, Kumegawa M 1992 Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology 131:1075-1080
24. Kanatani M, Sugimoto T, Fukase M, Chihara K 1994 Role of interleukin-6 and prostaglandins in the effect of monocyte-conditioned medium on osteoclast formation. Am J Physiol 267:E868-E876
25. Kurihara N, Suda T, Miura Y, Nakauchi H, Kodama H, Hiura K, Hakeda Y, Kumegawa M 1989 Generation of osteoclasts from isolated hematopoietic progenitor cells. Blood 74:1295-1302
26. Sugimoto T, Kanatani M, Kaji H, Yamaguchi T, Fukase M, Chihara K 1993 Second messenger signaling of PTH- and PTH-related peptide-stimulated osteoclast-like cell formation from mouse hemopoietic blast cells: role of cAMP-dependent protein kinase and protein kinase C. Am J Physiol 265:E367-E373
27. Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin TJ, Suda T 1990 Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci USA 87:7260-7264
28. Orimo H, Fujita T, Yoshikawa M 1972 Increased sensitivity of bone to parathyroid hormone in ovariectomized rats. Endocrinology 90: 760-763
29. Juppner H, Abou-Samra AB, Freeman MW, Kong XF, Schipani E, Richards J, Kolakowski LF Jr, Hock J, Potts Jr JT, Kronenberg HM, Segre GV 1991 A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024-1026
30. Kaji H, Sugimoto T, Fukase M, Chihara K 1993 Role of dual signal transduction systems in the stimulation of bone resorption by parathyroid hormone-related peptide: the direct involvement of cAMP-dependent protein kinase. Horm Metab Res 25:421-424
31. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC 1992 Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257:88-91
32. Greenfield EM, Shaw SM, Gornik SA, Banks MA 1995 Adenylate cyclase and interleukin 6 are downstream of parathyroid hormone resulting in stimulation of bone resorption. J Clin Invest 96:1238-1244
33. McSheehy PMJ, Chambers TJ 1986 Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoclastic bone resorption. Endocrinology 119:1654-1659
34. Fiorelli G, Gori F, Petilli M, Tanini A, Benvenuti S, Serio M, Bernabei P, Brandi ML 1995 Functional estrogen receptors in a human preosteoclastic cell line. Proc Natl Acad Sci USA 92:2672-2676
35. Civitelli R, Reid IR, Westbrook S, Avioli LV, Hruska KA 1987 PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line. Am J Physiol 255:E660-E667
36. Reeve J, Hesp R, Wiliams D, Hulme P, Klenerman L, Zanelli JM, Darby AJ, Tregear GW, Parsons JA 1976 Anabolic effect of low-doses of a fragment of human parathyroid hormone on the skeleton in postmenopausal osteoporosis. Lancet 1:1035-1038
37. Shen V, Dempster DW, Birchman R, Xu R, Lindsay R 1993 Loss of cancellous bone mass and connectivity in ovariectomized rats can be restored by combined treatment with parathyroid hormone and estradiol. J Clin Invest 91:2479-2487