Influence of lipophilicity on the diffusion of cephalosporins into the cerebrospinal fluid

Fundamental and Clinical Pharmacology

Volumn 10, Issue 3, 1996, Pages 309-313

  Radouane, A ^a   Pehourcq F ^a   Tramu, G ^a   Creppy, E E ^a   Bannwarth, B ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Cephalosporins; Diffusion into CSF; Lipophilicity; QSAR

Indexed keywords

CEFALORIDINE; CEFALOTIN; CEFAZOLIN; CEFOPERAZONE; CEFOTIAM; CEFOXITIN; CEFSULODIN; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DIFFUSION; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG PENETRATION; INTRAMUSCULAR DRUG ADMINISTRATION; LIPOPHILICITY; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 0030013705     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1996.tb00311.x     Document Type: Article

References (19)

1. Bannwarth B, Netter P, Pourel J, Royer RJ, Gaucher A. Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in the cerebrospinal fluid. Biomed Pharmacother 1989;43:121-6
2. Braumann T. Determination of hydrophobic parameter by reversed-phase liquid chromatography: theory, experimental techniques, and application in studies on quantitative structure-activity relationships. J Chromatogr 1986;373: 191-220
3. Bonati M, Kanto J, Tognoni G. Clinical pharmacokinetics of cerebrospinal fluid. Clin Pharmacokinet 1982;7:312-35
4. Demotes-Mainard FM, Vinçon GA, Jarry CH, Albin HC. Micromethod for determination of cefotaxime and desacetylcefotaxime in plasma and urine by high performance liquid chromatography. J Chromatogr 1984;336:438-45
5. Demotes-Mainard F, Jarry C, Thomas J, Dallet P. RP-HPLC retention data of new 2-amino-2-oxazolines. An approach of their lipophilic properties. J Liquid Chromatrogr 1991; 14:795-805
6. Dorsey JG, Khaledi MG. Hydrophobicity estimations by reversed-phase liquid chromatography. Implications for biological partitioning processes. J Chromatogr 1993;656: 485-99
7. Hansch C. Quantitative structure-activity relationships in drug design. In: Arïens EJ, ed. Drug Design. New York: Academic Press, 1971;Vol 1:271-342
8. Klepser ME, Marangos MN, Patel BP, Nicolau DP, Quintiliani R, Nightingale CH. Clinical pharmacokinetics of newer cephalosporins. Clin Pharmacokinet 1995;28:361-84
9. Kubinyi H. QSAR: Hansch analysis and related approaches. In: Mannhold R, Krogsgaard-Larsen P, Timmerman H, eds. Methods and Principles in Medicinal Chemistry, Vol 1. New York: VCH Publishers, 1993;1-13
10. Matsushita H. Facilitated transport of cefodizime into the rat central nervous system. J Pharmacol Exp Ther 1991;259: 620-7
11. Maurizio B, Jussi K, Gianni T. Clinical Pharmacokinetics of cerebrospinal fluid. Clin Pharmacokinet 1982;7:312-5
12. Nau R, Zysk G, Thiel A, Prange H. Pharmacokinetic quantification of the exchange of drugs between blood and cerebrospinal fluid in man. Eur J Clin Pharmacol 1993;45: 469-74
13. Neu HC. Cephalosporins in treatment of meningitis. Drugs 1987;34:135-41
14. Nohjoh T, Suzuki H, Sawada Y, Hanano M. Transport of cefodizime, a novel third generation cephalosporin antibiotic, in isolated rat choroid plexus. J Pharmacol Exp Ther 1989;1:324-31
15. Péhourcq FDM, Radouane A, Labat L, Bannwarth B. Influence of lipophilicity on the protein binding affinity of cephalosporins. Pharmaceut Reas 1995;12:1535-8
16. Petraukas AA, Svedas VK. Hydrophobicity of β-lactams antibiotics. Explanation and prediction of their behaviour in various solvent systems and reversed-phase chromatography. J Chromatogr 1991;585:3-34
17. Suzuki H, Sawada Y, Sugiama Y, Iga T, Hanano M. Anion exchanger mediates benzylpenicillin transport in rat choroid plexus. J Pharmacol Exp Ther 1987;243:1147-53
18. Tawara S, Matsumoto S, Matsumoto Y, Kamimura T, Goto S. Structure-binding relationship and binding sites of cephalosporins in human serum albumin. J Antibiot (Tokyo) 1992;45:1346-57
19. Wayne AC, Margaret LJ. Relationships between CSF drug concentrations, receptor binding characteristics, and pharmacokinetic and pharmacodynamic properties of selected 1,4-substitued benzodiazepines. Clin Pharmacokinet 1987; 13:179-90