Clinical significance of the increased peak levels of exhaled nitric oxide in patients with bronchial asthma

Internal Medicine

Volumn 35, Issue 4, 1996, Pages 270-275

  Satouchi, Miyako ^a   Maeda, Hitoshi ^a   Yu, Yohko ^a   Yokoyama, Mitsuhiro ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

breath holding; chemiluminescence method; induced sputum; inhaled provocation test; peak expiratory flow rate

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; GLUCOCORTICOID; NITRIC OXIDE; XANTHINE DERIVATIVE;

ADULT; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION TEST; MALE; ORAL DRUG ADMINISTRATION; PEAK EXPIRATORY FLOW; PROVOCATION TEST;

EID: 0030013697     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.35.270     Document Type: Article

References (27)

1. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathphysiology, and pharmacology. Pharmacol Rev 43: 109, 1991.
2. Moncada S, Higgs A. The L-arginme-nitric oxide pathway. N Eng J Med 329: 2002, 1993.
3. Jorens PG, Vermeire PA, Herman AG. L-arginine-dependent nitric oxide synthase: a new metabolic pathway in the lung and airways. Eur Respir J 6: 258, 1993.
4. Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med 149: 538, 1994.
5. Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea-pigs and humans. Biochem Biophys Res Commun 181: 852, 1991.
6. Persson MG, Wiklund NP, Gustafsson LE. Endogenous nitric oxide in single exhalations and the change during exercise. Am Rev Respir Dis 148: 1210, 1993.
7. Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 6: 1368, 1993.
8. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shineboume EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 343: 133, 1994.
9. Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 151: 1894, 1995.
10. Kharitonov SA, Yates D, Barnes PJ. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur Respir J 8: 295, 1995.
11. Kharitonov SA, Wells AU, O'Connor BJ, et al. Elevated levels of exhaled nitric oxide in bronchiectasis. Am J Respir Crit Care Med 151: 1889, 1995.
12. Persson MG, Gustafsson LE. Allergen-induced airway obstruction in guinea-pigs is associated with changes in nitric oxide levels in exhaled air. Acta Physiol Scand 149: 461, 1993.
13. Bousquet J, Michel FB. International concensus report on diagnosis and management of asthma. Allergy 47: 129, 1992 (editorial).
14. Jorens PJ, van Overveld FJ, Bult H, Vermeire PA, Herman AG. Larginine-dependent production of nitrogen oxides by rat pulmonary macrophages. Eur J Pharmacol 200: 205, 1991.
15. Asano K, Chee CBE, Gaston B, et al. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc Natl Acad Sci USA 91: 10089, 1994.
16. Harald Q, Springall DR, Riveros-Moreno V, et al. Induction of nitric oxide synthase in asthma. Lancet 342: 1510, 1993.
17. Pin I, Gibson PG, Kolendowicz R, et al. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 47: 25, 1992.
18. Ciaman DM, Boushey HA, Liu J, Wong H, Fahy JV. Analysis of induced sputum to examine the effect of prednisone on airway inflammation in asthmatic subjects. J Allergy Clin Immunol 94: 861, 1994.
19. Persson MG, Zetterstrom O, Agrenius V, Ihre E, Gustafsson LE. Single-breath nitric oxide measurements in asthmatic patients and smokers. Lancet 343: 146, 1994.
20. Takishima T, Hida W, Sasaki H, Suzuki S, Sasaki T. Direct-writing recorder of the dose-response curves of the airway to methacholine. Clinical application. Chest 80: 600, 1981
21. Gerlach H, Rossaint R, Pappert D, Knorr M, Falke KJ. Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 343:518, 1994 (see comments).
22. Robbins RA, Barnes PJ, Springall DR, et al. Expression of inducible nitric oxide in human lung epithelial cells. Biochem Biophys Res Commun 203:209, 1994.
23. Adcock IM, Brown CR, Kwon O, Barnes PJ. Oxidative stress induces NK. kappa B DNA binding and inducible NOS mRNA in human epithelial cells. Biochem Biophys Res Commun 199: 1518, 1994.
24. Lundberg JON, Weitzberg E, Nordvall SL, Kuylenstiema R, Lundberg JM, Alving K. Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome. Eur Respir J 7: 1501, 1994.
25. Kharitonov SA, Yates DH, Robbins RA, Thomas PS, Barnes PJ. Corticosteroids decreased exhaled nitric oxide. Am J Respir Crit Care Med 149: A201, 1994.
26. Fahy JV, Wong H, Liu J, Boushey HA. Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects. Am J Respir Crit Care Med 152: 53, 1995.
27. Popov TA, Pizzichini MMM, Pizzichmi E, et al. Some technical factors influencing the induction of sputum for cell analysis. Eur Respir J 8: 559. 1995.