Lack of interaction between pantoprazole and digoxin at therapeutic doses in man

International Journal of Clinical Pharmacology and Therapeutics

Volumn 34, Issue SUPPL. 1, 1996, Pages

  Hartmann, M ^a   Huber, R ^a   Bliesath, H ^a   Steinijans, V W ^a   Koch, H J ^a   Wurst, W ^a   Kunz, K ^b  

^a ALTANA PHARMA AG   (Germany)

^b Inst F Bioanalytische Forschung   (Germany)

Author keywords

Digoxin; Interaction; Pantoprazole; Proton pump inhibitor

Indexed keywords

ACETYLDIGOXIN; CARDIAC GLYCOSIDE; CYTOCHROME P450; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; PANTOPRAZOLE; PROTON PUMP INHIBITOR;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG INTERACTION; DRUG SAFETY; ELECTROCARDIOGRAPHY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STOMACH PH;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ADULT; AREA UNDER CURVE; BENZIMIDAZOLES; CARDIOTONIC AGENTS; CROSS-OVER STUDIES; DIGOXIN; DRUG INTERACTIONS; ELECTROCARDIOGRAPHY; ENZYME INHIBITORS; FEMALE; H(+)-K(+)-EXCHANGING ATPASE; HUMANS; MALE; OMEPRAZOLE; SINGLE-BLIND METHOD; SULFOXIDES;

EID: 0030013521     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Andersson T, Andrèn K, Cederberg C, Advardsson G, Heggelunch A, Lundborg P 1990 Effect of omeprazole and cimetidine on plasma diazepam levels. Eur J Clin Pharmacol 39: 51-54
2. Bliesath H, Huber R, Hartmann M, Kunz K, Koch HJ, Wurst W 1994 Pantoprazole does not influence the steady-state pharmacokinetics of nifedipine. Gastroenterol 106 (Suppl): A55
3. Bliesath H, Huber R, Hartmann M, Steinijans VW, Koch H, Wurst W 1995 Pantoprazole does not interact with diclofenae. Gastroenterol 108 (Suppl.): A61
4. Cohen AF, Kroon R, Schoemaker R, Hoogkamer H, van Vliet A 1991 Influence of gastric acidity on the bioavailability of digoxin. Ann Intern Med 115: 540-545
5. Cohen AF, Krooon R, Schoemaker R, Breimer DD, van Vliet-Verbeek A, Brandenburg HC 1993 The bioavailability of digoxin from three oral formulations measured by specific h.p.l.c. assay. Br J Clin Pharmacol 35: 136-142
6. de Mey C, Meineke I, Steinijans VW, Huber R, Hartmann M, Bliesath H, Wurst W 1994 Pantoprazole lacks interaction with antipyrine in man, either by inhibition or induction. Int J Clin Pharmacol Ther 32: 98-106
7. Diletti E, Hauschke D, Steinijans VW 1991 Sample size determination for bioequivalence assessment by means of confidence intervals. Int J Clin Pharmacol Ther Toxicol 29: 1-8
8. Duursema L, Müller FO, Schall R, Middle MV, Hundt HKL, Groenewoud G, Steinijans VW, Bliesath H 1995 Lack of effect of pantoprazole on the pharmacodynamics and pharmacokinetics of warfarin. Br J Clin Pharmacol 39: 700-703
9. Ehrlich A, Fuder H, Hartmann M, Timmer W, Huber R, Birkel M, Bliesath H, Steinijans VW, Wurst W 1995 Lack of pharmacokinetic and pharmacodynamic interaction of pantoprazole and phenprocoumon in man. Gastroenterol 108 (Suppl.): A86
10. Gugler R, Hartmann M, Rudi J, Bliesath H, Brod I, Klotz U, Huber R, Steinijans VW, Wurst W 1992 Lack of interaction of pantoprazole and diazepam in man. Gastroenterol 102 (Suppl): A77
11. Gugler G, Jensen JC 1985 Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethocxycoumarin in vitro. Gastroenterol 89: 1235-1241
12. Hartmann M, Bliesath H, Zech K, Koch H, Steinijans VW, Wurst W, Mascher H 1995 Pantoprazole does not influence CYPIA2 activity in man. Gastronenterol 108 (Suppl): A109
13. +-ATPase inhibitor BY1023/SK&F96022 and its sulphone metabolite in serum or plasma by direct injection and fully automated precolumn sample cleanup. J Chromatogr 529: 389-401
14. Kano H, Okumo H, Takasu M, Takeda K, Shiozaki Y, Inoue K 1992 Inhibition and induction of liver drug metabolizing activity by omeprazole. Hepatic J Gastroenterol 5 (Suppl.): 150
15. Kromer W, Postius S, Riedel R, Simon WA, Hanauer G, Brand U, Gönne S, Parsons ME 1990 BY1023/SK&F96022 INN pantoprazole, a novel gastric proton pump inhibitor, potently inhibits acid secretion but lacks relevant cytochrome P450 interactions. J Pharmacol Exp Ther 254: 129-135
16. Middle MV, Müller FO, Schall R, Hundt HKL, Mogilnicka EM, Beneke PC 1995 Effect of pantoprazole on ovulation suppression by a low-dose hormonal contraceptive. Clin Drug Invest 9: 54-56
17. Middle MV, Müller FO, Schall R, Groenewoud G, Hundt HKL, Huber R, Bliesath H, Steinijans VW 1995 No influence of pantoprazole on the pharmacokinetics of phenytoin. Int J Clin Pharmacol Ther 33: 304-307
18. Naidu MUR, Shobha JC, Dixit VK, Kumar A, Kumar TR, Sekhar KR, Sekhar EC 1994 Effect of multiple dose omeprazole on the pharmacokinetics of carbamazepine. Drug Invest 7: 8-12
19. Oosterhuis B, Jonkmann JHG, Andersson T, Zuiderwijk PBM, Jedema JN 1991 Minor effects of multiple dose omeprazole on the pharmacokinetics of digoxin after a single oral close. Br J Clin Pharmacol 32: 569-572
20. Sauter R, Steinijans VW, Diletti E, Böhm A, Schulz H-U 1992 Presentation of results from bioequivalence studies. Int J Clin Pharmacol Ther Toxicol 30: 233-256
21. Schulz H-U, Hartmann M, Steinijans VW, Huber R, Lührmann R, Bliesath H, Wurst W 1991 Lack of influence of pantoprazole on the disposition kinetics of theophylline in man. Int J Clin Pharmacol Ther Toxicol 29: 369-375
22. +-ATPase inhibitor BY1023/SK&F96022- inhibition of pentagastrin-stimualted gastric acid secretion and pharmacokinetics in man. Aliment Pharmacol Ther 4: 239-245
23. +-ATPase inhibitor pantoprazole (BY1023/SK&F96022) in healthy volunteers. Z Gastroenterol 28: 443-447
24. Simon B, Müller P, Marinis E, Lühmann R, Huber R, Hartmann M, Wurst W 1990c Effect of repeated oral administration of BY1023/SK&F96022 - a new substituted benzimidazole derivative - on pentagastrin-stimulated gastric acid secretion and pharmacokinetics in man. Aliment Pharmacol Ther 4: 373-379
25. +-ATPase inhibitor pantoprazole (BY1023/SK&F96022) interacts less with cytochrome P450 than omeprazole and lansoprazole. Biochem Pharmacol 42: 347-355
26. Steinijans VW, Hartmann M, Huber R, Radtke HW 1991 Lack of pharmacokinetic interaction as an equivalence problem. Int J Clin Pharmacol Ther Toxicol 29: 323-328