Very low protein diets induce a rapid decrease in hepatic cAMP-dependent protein kinase followed by a slower increase in adenylyl cyclase activity in rats

Journal of Nutrition

Volumn 126, Issue 7, 1996, Pages 1799-1807

  Stephen, L L ^a   Nagy, L E ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

adenylyl cyclase; cAMP dependent protein kinase; liver; malnutrition; rats

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP DEPENDENT PROTEIN KINASE;

ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME SUBUNIT; LIVER CELL; NONHUMAN; PHOSPHATE METABOLISM; PROTEIN MALNUTRITION; PROTEIN RESTRICTION; RAT; TISSUE DISTRIBUTION;

ADENYLATE CYCLASE; ANIMALS; BODY WEIGHT; CHLORIDES; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIET, PROTEIN-RESTRICTED; GLUCAGON; LIVER; MALE; MANGANESE COMPOUNDS; NUTRITION DISORDERS; ORGAN SIZE; PROTEIN DEFICIENCY; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030013494     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Aasheim, L. H., Kleine, L. P. & Franks, D. F. (1989) Activation of protein kinase C sensitizes the cyclic AMP signalling system of T51B rat liver cells. Cell. Signalling 1: 617-625.
2. Bauman, P. F., Smith, T. K. & Bray, T. M. (1988) The effect of dietary protein deficiency and L-2-oxothiazoline-4-carboxylate on the diurnal rhythm of hepatic glutathione in the rat. J. Nutr. 118: 1048-1054.
3. Boynton, A. L. & Whitfleld, J. F. (1983) The role of cAMP in cell proliferation: a critical assessment of the evidence. Adv. Cyclic Nucl. Res. 15: 193-294.
4. Cho-Chung, Y. S. (1990) Role of cAMP receptor proteins in growth, differentiation and suppression of malignancy: new approaches to therapy. Cancer Res. 50: 7093-7100.
5. Ekanger, R., Vintermyr, O. K. & Døskeland, S. O. (1988) The amounts of rat liver cyclic AMP-dependent protein kinase I and II are differentially regulated by diet. Biochem. J. 256: 447-452.
6. Fouchereau, P. M., Rancon, F., Freychet, P. & Rosselin, G. (1976) Effect of feeding and fasting on the early steps of glucagon action in isolated rat liver cells. Endocrinology 98: 755-760.
7. Frandsen, E. K. & Krishna, G. (1977) A simple ultrasensitive method for the assay of cAMP and cGMP in tissues. Life Sci. 18: 529-542.
8. GOSS, P., Bray, T. M. & Nagy, L. E. (1994) Regulation of hepatocyte glutathione by amino acid precursors and cAMP in protein-energy malnourished rats. J. Nutr. 124: 323-330.
9. Hemmings, J.J. (1986) cAMP mediated proteolysis of the catalytic subunit of cAMP-dependent protein kinase. FEBS Lett. 196: 126-130.
10. Heyworth, C. M., Whetton, A. D., Kinsella, A. R. & Houslay, M. D. (1984) The phorbol ester, TPA inhibits glucagon-stimulated adenylate cyclase activity. FEBS Lett. 170: 38-42.
11. Houge, G., Vintermyr, O. K. & Døskeland, S. O. (1990) The expression of cAMP-dependent protein kinase subunits in primary rat hepatocyte cultures. Cyclic AMP down-regulates its own effector system by decreasing the amount of catalytic subunit and increasing the mRNAs for the inhibitor (R) subunits of cAMP-dependent protein kinase. Mol. Endocrinol. 4: 481-488.
12. Hug, H. & Sarre, T. F. (1993) Protein kinase C isoenzymes: divergence in signal transduction? Biochem. J. 291: 329-343.
13. Iyengar, R. (1993) Molecular and functional diversity of mammalian Gs-stimulated adenylyl cyclases. FASEB J. 7: 768-775.
14. Kapoor, C. L. & Cho-Chung, Y. S. (1983) Compartmentalization of regulatory subunits of cAMP dependent protein kinase in MCF-7 human breast cancer cells. Cancer Res. 43: 295-302.
15. Kawabe, J., Iwami, G., Ebina, T., Ohno, S., Katada, T., Ueda, Y., Homey, C. J. & Ishikawa, Y. (1994) Differential activation of adenylyl cyclase by protein kinase C isoenzymes. J. Biol. Chem. 269: 16554-16558.
16. Kemp, B. E., Cheng, H. C. & Walsh, D. A. (1988) Peptide inhibitors of cAMP-dependent protein kinase. Methods Enzymol. 159: 173-183.
17. Krebs, E. G. & Beavo, J. A. (1979) Phosphorylation-dephosphorylation of enzymes. Ann. Rev. Biochem. 48: 923-959.
18. Laemmli, U. K. (1970) Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature (Lond.) 227: 680-685.
19. Maurer, R. A. (1981) Transcriptional regulation of the prolactin gene by ergocryptine and cAMP. Nature (Lond.) 294: 94-97.
20. Noda, C., Shinjyo, F., Tomomura, A., Kato, S., Nakamura, T. & Ichihara, A. (1984) Mechanism of heterologous desensitization of the adenylate cyclase system by glucagon in primary cultures of adult rat hepatocytes. J. Biol. Chem. 259: 7747- 7754.
21. Premont, R. T., Chen, J., Ma, J. H., Ponnapalli, M. & Iyengar, R. (1992a) Two members of a widely expressed subfamily of hormone stimulated adenylyl cyclases. Proc. Natl. Acad. Sci. U.S.A. 89: 9809-9813.
22. Premont, R. T. & Iyengar, R. (1988) Glucagon induced desensitization of adenylyl cyclase in primary cultures of chick hepatocytes. Evidence for multiple pathways. J. Biol. Chem. 263: 16087-16095.
23. Premont, R. T., Jacobowitz, O. & Iyengar, R. (1992b) Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by Gs in heterologous desensitization: a role for adenosine 3′,5′-monophosphate-dependent phosphorylation. Endocrinology 131: 2774-2784.
24. Rohlff, C., Clair, T. & Cho-Chung, Y. S. (1993) 8-Cl-cAMP induces truncation and down-regulation of the RII subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J. Biol. Chem. 268: 5774-5782.
25. Rozwadowski, M., Stephen, L. L., Goss, P., Bray, T. M. & Nagy, L. E. (1995) Decreased activity of cAMP-dependent protein kinase in protein-energy malnourished rats. J. Nutr. 125: 401-409.
26. Sibley, D. R. & Lefkowitz, R. J. (1985) Molecular mechanisms of receptor desensitization using β-adrenergic receptor-coupled adenylate cyclase as a model. Nature (Lond.) 317: 124-129.
27. Soman, V. & Felig, P. (1978) Regulation of the glucagon receptor by physiological hyperglucagonemia. Nature (Lond.) 272: 829-832.
28. Steel, R. G. D. & Torrie, J. H. (1980) Principles and Procedures of Statistics: A Biometrical Approach, 2nd ed. McGraw-Hill Book Company, New York, NY.
29. Tortora, G., Pepe, S., Bianco, C., Diamano, V., Ruggiero, A., Baldassarre, G., Corbo, C., Cho-Chung, Y. S. Bianco, A. R. & Ciardello, F. (1994) Differential effects of protein kinase A sub-units on Chinese-hamster ovary cell cycle proliferation. Int. J. Cancer 59: 712-716.
30. Weber, W. & Hilz, H. (1986) cAMP-dependent protein kinase I and II: Divergent turnover of subunits. Biochemistry 25: 5661-5667.