Normalization of peripheral thyroid hormone metabolism induced by successful chronic amiodarone treatment in patients with ventricular arrhythmias

European Journal of Clinical Investigation

Volumn 26, Issue 5, 1996, Pages 382-390

  Iervasi, G ^a   Clerico, A ^a   Berti, S ^a   Pilo, A ^a   Biagini, A ^a   Bianchi, R ^b   Donato, L ^a  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Amiodarone; arrhythmias; thyroid hormone metabolism; thyroid hormones

Indexed keywords

AMIODARONE;

ADULT; AGED; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HEART VENTRICLE ARRHYTHMIA; HUMAN; KINETICS; LIOTHYRONINE BLOOD LEVEL; MALE; METABOLIC CLEARANCE RATE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; THYROID HORMONE METABOLISM; THYROID HORMONE SYNTHESIS; THYROXINE BLOOD LEVEL;

EID: 0030013357     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1996.127300.x     Document Type: Article

References (18)

1. Figge HL, Figge J. The effects of amiodarone on thyroid hormone function: a review of the physiology and clinical manifestations. J Clin Pharmacol 1990;30:588-95.
2. Gill J, Heel RC, Fitton A. Amiodarone. An overview of its pharmacological properties, and review of its therapeutic use in cardiac arrhythmias. Drugs 1992;43:69-110.
3. Linger J, Lambert M, Jonckheer MH, Denayer Ph. Amiodarone and the thyroid: pharmacological, toxic and therapeutic effects. J Intern Med 1993;233:435-43.
4. Polikar R, Burger AG, Scherrer U, Nicod P. The thyroid and the heart. Circulation 1993;87:1435-41.
5. Venkatesh N, Lynch JJ, Uprichard ACG, Kitzen JM, Singh BN, Lucchesi BR. Hypothyroidism renders protection against lethal ventricular arrhythmias in a conscious canine model of sudden death. J Cardiovasc Pharmacol 1991;18:703-10.
6. Kannan R, Chopra IJ, Ookhtens M, Singh BN. Effect of amiodarone on non-deiodinative pathway of thyroid hormone metabolism. Acta Endocrinol 1990;122:249-54.
7. Lambert MJ, Burger AG, Galeazzi RL, Engler D. Are selective increases in serum thyroxine (T4) due to iodinated inhibitors of T4 monodeiodination indicative of hyperthyroidism? J Clin Endocrinol Metab 1982;55:1058-65.
8. Hershman JM, Nademanee K, Sugawara M R et al. Thyroxine and triiodothyronine kinetics in cardiac patients taking amiodarone. Acta Endocrinol 1986;111:193-9.
9. Pilo A, Iervasi G, Vitek F, Ferdeghini M, Cazzuola F, Bianchi R. Thyroidal and peripheral production of. 3,5,3′-triiodothyronine in humans by multicompartmental analysis. Am J Physiol 1990;258: E715-26.
10. Pilo A, Iervasi G, Vitek F, Turchi S, Bianchi R. Disposal and distribution of rT3 in humans: a new double-tracer kinetic study. Am J Physiol 1993; 264: E239-49.
11. Biagini A, Iervasi G, Clerico A et al. L. Peripheral thyroid hormone metabolism in patients with complex ventricular arrhythmias. Am J Cardiol 1995;75:630-3.
12. Manfredi C, Clerico A, Iervasi G et al. Measurement of serum amiodarone and desethylamiodarone by HPLC: its usefulness in the follow-up of arrhythmic patients treated with amiodarone. Clin Pharmacol Res 1995;15:87-93.
13. Zonszein J, Fein FS, Sonnenblick EH. Heart and endocrine disease. In: Sciant RC, Alexander RW, eds. The Heart. Arteries and Veins, 8th edn. London: McGraw-Hill, 1994: 1907-20.
14. Gotzsche BHL, Orskov H. Cardiac triiodothyronine nuclear receptor binding capacities in amiodarone-treated, hypo- and hyperthyroid rats. Eur J Endocrinol 1994;130:281-90.
15. Burger A, Dinichert D, Nicod P, Jenny M, Lemarchand-Beraud T, Vallotton MB. Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine, thyroxine and thyrotropin. A drug influencing peripheral metabolism of thyroid hormones. J Clin Invest 1976;58:255-61.
16. Nicoloff JT, LoPresti JS. Nonthyroidal illness. In: The Thyroid. A Fundamental and Clinical Text. Braverman LE, Utiger RD, eds. Philadelphia: JB Lippincott, 1991: 357-68.
17. Chess-Williams R, Coker SJ. Ventricular fibrillation is reduced in hypothyroid rats with enhanced myocardial alpha-adrenoceptors responsiveness. Br J Pharmacol 1989;98:95-100.
18. Yin YL, Perret GY, Nicolas P, Vassy R, Uzzan B, Tod M. In vivo effects of amiodarone on cardiac beta-adrenoceptor density and heart rate require thyroid hormones. J Cardiovasc Pharmacol 1992;19:541-5.