Luteinizing Hormone-Releasing Hormone (LHRH) receptors in the neuroendocrine-immune network: Biochemical bases and implications for reproductive physiopathology

Annals of the New York Academy of Sciences

Volumn 784, Issue , 1996, Pages 209-236

  Marchetti, Bianca ^a   Gallo, Francesco ^a   Farinella, Zelinda ^a   Romeo, Carmela ^a   Morale, Maria C ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; CYTOKINE; GLUCOCORTICOID RECEPTOR; GONADORELIN RECEPTOR; GONADOTROPIN; NEUROTENSIN; SEX HORMONE; SOMATOSTATIN;

ADENOHYPOPHYSIS; AMINO ACID SEQUENCE; ANIMAL CELL; ASTROCYTE; BREAST TUMOR; CONFERENCE PAPER; CONTROLLED STUDY; DIESTRUS; ESTRUS CYCLE; FEMALE; FEMALE GENITAL SYSTEM; GENITAL SYSTEM; GONAD; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; IMMUNE SYSTEM; LUTEINIZING HORMONE RELEASE; MAMMARY GLAND; NEUROENDOCRINE SYSTEM; NONHUMAN; PLACENTA; PREGNANCY; PROESTRUS; RAT; SEX DIFFERENCE; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030012887     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb16238.x     Document Type: Article

References (117)

1. AMOSS, M., R. BURGES, R. BLACKWELL, W. VALE, R. FELLOWS & R. GUILLEMIN. 1971. Purification and amino-acid composition and N-terminus of the hypothalamic luteinizing hormone-releasing hormone factor (LRF) of ovine origin. Biochem. Biophys. Res. Commun. 44: 205-210.
2. SCHALLY, A. V., A. ARIMURA, Y. BAKER, R. NAIR, H. MATSUO, T. W. REDDING, L. DEBELJUK & W. F. WHITE. 1971. Isolation and properties of the FSH- and LH-releasing hormone. Biochem. Biophys. Res. Commun. 43: 393-399.
3. MATSUO, H., Y. BABA, R. M. G. NAU, A. ARIMURA & A. V. SCHALLY. 1971. Structure of the porcine LH and FSH releasing hormone. I. Proposed amino-acid sequence. Biochem. Biophys. Res. Commun. 43: 134-139.
4. HODGEN, G. D. & J. ITSKOVITZ. 1988. Recognition and maintenance of pregnancy. In The Physiology of Reproduction. E. Knobil & J. D. Neill, Eds.: 1995. Raven Press. New York.
5. SARGENT, I. L. 1993. Maternal and fetal immune responses during pregnancy. Exp. Clin. Immunogenet. 10: 85.
6. USSA, J. E., A. P. CADAVID & J. G. MALDONADO. 1994. Is the immune system necessary for placental reproduction? A hypothesis on the mechanisms of alloimmunotherapy in recurrent spontaneous abortion. Med. Hypotheses 42: 193.
7. EVERETT, J. W. 1988. Pituitary and hypothalamus: perspectives and overview. In The Physiology of Reproduction. E. Knobil & J. D. Neill, Eds.: 1143. Raven Press. New York.
8. MARCHETTI, B., M. CIONI & U. SCAPAGNINI. 1985. Ovarian LHRH receptors increase following lesions of the major LHRH structures in the rat brain: involvement of a direct neural pathway. Neuroendocrinology 41: 321.
9. MARCHETTI, B., M. CIONI & U. SCAPAGNINI. 1986. Hypophyseal and gonadal receptors for luteinizing hormone-releasing hormone LHRH in aging rats: neuroendocrine markers of central versus peripheral LHRH activity. In Neuroendocrine Perspectives. Volume 5. E. E. Muller & R. M. MacLeod, Eds.: 205. Elsevier. Amsterdam/New York.
10. MARCHETTI, B., M. CIONI, M. BADR, N. FOLLEA & G. PELLETIER. 1987. Ovarian adrenergic nerves directly participate in the control of luteinizing hormone-releasing hormone and adrenergic receptors during puberty: a biochemical and autoradiographic study. Endocrinology 121: 219.
11. OJEDA, S. R., H. F. URBANSKI, M. E. COSTA, D. F. HILL & M. MOHOLT-SIEBERT. 1990. Involvement of transforming growth factor α in the release of luteinizing hormone-releasing hormone from the developing female hypothalamus. Proc. Natl. Acad. Sci. U.S.A. 87: 9698-9702.
12. OJEDA, S. R., G. A. DISSEN & M. P. JUNIER. 1993. Neurotrophic factors and female sexual development. Front. Neuroendocrinol. 13: 120-162.
13. JUNIER, M. P., D. F. HILL, M. E. COSTA, S. FELDER & S. R. OJEDA. 1993. J. Neurosci. 13: 703-713.
14. MA, Y. J., M. P. JUNIER, M. E. COSTA & S. R. OJEDA. 1992. Neuron 9: 657-670.
15. LABRIE, F., F. A. LEFEBVRE, B. MARCHETTI, G. PELLETIER, M. GODBOUT, C. SÈGUIN, L. FERLAND, J. MASSICOTTE, J. P. BORGUS & V. GIGUÈRE. 1982. Control of luteinizing hormone-releasing hormone receptor levels and activity in the anterior gland and gonad. In Pituitary Hormone and Related Peptides. M. Motta, M. Zanisi & F. Piva, Eds.: 201-222. Academic Press. New York/London.
16. MARCHETTI, B. & F. LABRIE. 1983. Hormonal control of luteinizing hormone-releasing hormone activity in the rat anterior pituitary gland. In Neuropeptides, Neurotransmitters, and Regulation of Endocrine Processes. E. Endroczi, L. Angelucci, U. Scapagnini & D. De Wied, Eds.: 11-18. Akad. Kiadò. Budapest.
17. LABRIE, F., B. MARCHETTI, L. PROULX-FERLAND, V. GIGUÈRE, F. A. LEFEBVRE & M. LAVOIE. 1983. Characteristics of the LHRH and CRF receptors in the rat anterior pituitary gland. In Hormone Receptors and Receptor Diseases. H. Imura & H. Kuzuya, Eds.: 53-67. Excerpta Medica. Amsterdam.
18. MARCHETTI, B., F. LABRIE, G. PELLETIER, L. PROULX-FERLAND & J. J. REEVES. 1983. Hormonal control of pituitary luteinizing hormone-releasing hormone receptors. In Recent Advances in Male Reproduction: Molecular Basis and Clinical Implications. R. D'Agata, M. B. Lipsett, P. Polos & H. J. Van der Molen, Eds.: 215-226. Raven Press. New York.
19. CONN, P. M. 1986. The molecular basis of gonadotropin-releasing hormone action. Endocr. Rev. 7: 3-10.
20. 2+: the case of LHRH. Endocr. Rev. 11: 326-353.
21. STOJILKOVIC, S. S., J. REINHART & K. J. CATT. 1994. Gonadotropin-releasing hormone receptors: structure and signal transduction pathways. Endocr. Rev. 15: 462.
22. TSUTSUMI, M., W. ZHOU, R. P. MILLAR, P. L. MELLON, J. L. ROBERTS, C. A. FLANAGAN, K. DONG, K. GILLO & S. C. SEALFON. 1992. Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor. Mol. Endocrinol. 6: 1163-1169.
23. REINHART, J., L. M. MERTZ & K. J. CATT. 1992. Molecular cloning and expression of a cDNA encoding the murine gonadotropin-releasing hormone receptor. J. Biol. Chem. 267: 21281-21284.
24. PERRIN, M. H., L. M. BILEZIKJIAN, C. HOEGER, C. V. DONALDSON, J. RIVIER, Y. HAAS & W. VALLE. 1993. Molecular and functional characterization of GnRH receptors cloned from rat pituitary and mouse pituitary tumor cell lines. Biochem. Biophys. Res. Commun. 191: 1139-1144.
25. KAKAR, S. S., L. C. MUSGROVE, D. C. DEVOR, J. C. SELLERS & J. D. NEILL. 1993. Cloning, sequencing, and expressing of human gonadotropin-releasing hormone (GnRH) receptor. Biochem. Biophys. Res. Commun. 189: 289-295.
26. CHI, L., W. ZHOU, A. PRIKHOZAN, C. FLANAGAN, J. S. DAVIDSON, N. ILLING, R. P. MILLAR & S. C. SEALFON. 1993. Cloning/characterization of the human GnRH receptor. Mol. Cell. Endocrinol. 91: R1-R6.
27. ILLING, N., G. F. M. JACOBS, A. BECKER II, C. A. FLANAGAN, L. DAVIDSON, A. EALES, W. ZHOU, S. C. SEALFON & R. P. MILLAR. 1993. Comparison sequence analysis and functional characterization of the sheep gonadotropin-releasing hormone receptor reveal differences in primary structure and ligand specificity among mammalian receptors. Biochem. Biophys. Res. Commun. 196: 745-751.
28. BROOKS, J., P. L. TAYLOR, P. T. K. SAUNDERS, K. A. EIDNE, E. STRUTHERS & A. S. MCNEILLY. 1993. Cloning and sequencing of the sheep pituitary gonadotropin-releasing hormone receptor and changes in expression of its mRNA during the estrous cycle. Mol. Cell. Endocrinol. 94: R23-R27.
29. ZHOU, W., C. FLANAGAN, J. A. BALLESTEROS, K. KONVICKA, J. S. DAVIDSON, H. WEINSTEIN, R. P. MILLAR & S. C. SEALFON. 1994. A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor. Mol. Pharmacol. 45: 165-170.
30. SILVERMAN, A-J. 1988. The gonadotropin-releasing hormone (GnRH) neuronal systems: immunocytochemistry. In The Physiology of Reproduction. E. Knobil & J. D. Neill, Eds. Raven Press. New York.
31. BADR, M., B. MARCHETTI & G. PELLETIER. 1988. Modulation of hippocampal LHRH receptors by sex steroids in the rat. Peptides 9: 441.
32. BADR, M., B. MARCHETTI & G. PELLETIER. 1989. Changes in hippocampal LHRH receptor density during maturation and aging in the rat. Dev. Brain Res. 45: 179-184.
33. CHOI, W. S., M. O. KIM, B. J. LEE, J. H. KIM, W. SUN, J. Y. SEONG & K. KIM. 1994. Presence of gonadotropin-releasing hormone mRNA in the rat olfactory piriform cortex. Brain Res. 64: 148.
34. SILVERMAN, A-J., R. P. MILLAR, J. A. KING, X. ZHUANG & R. SILVER. 1994. Mast cells with gonadotropin-releasing hormone-like immunoreactivity in the brain of doves. Proc. Natl. Acad. Sci. U.S.A. 91: 3695.
35. SUNDARAM, K., A. DIDOLKAR, R. THAU, M. CHANDHURI & F. SCHMIDT. 1988. Antagonists of luteinizing hormone-releasing hormone bind to rat mast cells and induce histamine release. Agents Actions 25: 307.
36. VLIAGOFTIS, H., V. DIMITRIADOU & T. C. THEOHARIDES. 1990. Progesterone triggers selective mast cell secretion of 5-hydroxytryptamine. Int. Arch. Allergy Appl. Immunol. 93: 113.
37. KOZLOWSKI, G. P. & P. W. COATES. 1990. Ependymo-neuronal specializations between LHRH fibers and cells of the cerebroventricular system. Cell Tissue Res. 242: 301-311.
38. SCHWANZEL-FUKUDA, M. & D. W. PFAFF. 1987. Origin of luteinizing hormone-releasing neurons. Nature 338: 161.
39. SILVERMAN, R. C., M. J. GIBSON & A-J. SILVERMAN. 1991. Exp. Neurol. 114: 259-274.
40. 1-1 neuronal cell lines. Endocrine 3: 867-874.
41. 1-1-astroglial cell cultures after activation of growth factor receptors: implications for neuronal-glial interactions. Twenty-fourth Annual Meeting of the Society for Neuroscience, Miami Beach, Florida.
42. MARCHETTI, B., V. GUARCELLO, G. TRIOLO, M. C. MORALE, Z. FARINELLA & U. SCAPAGNINI. 1989. Luteinizing hormone-releasing hormone (LHRH) as natural messenger in neuro-immune-endocrine communications. In Interactions among CNS, Neuroendocrine, and Immune Systems. J. W. Hadden, K. Masek & G. Nisticò, Eds.: 127. Pythagora Press. Rome/Milan.
43. BATTICANE, N., M. C. MORALE, F. GALLO, Z. FARINELLA & B. MARCHETTI. 1991. Luteinizing hormone-releasing hormone signaling at the lymphocyte involves stimulation of interleukin-2 receptor expression. Endocrinology 128: 277.
44. YAMAGUCHI, M., K. KOIKE, Y. YOSHIMOTO, N. MTASUZAKI, A. MIYAKE & O. TANIZAWA. 1991. Interleukin-6 stimulates gonadotropin-releasing hormone secretion from rat hypothalamic cells. Horm. Res. 35: 252.
45. 2 release to suppress pulsatile release of luteinizing hormone-releasing hormone, but not follicle-stimulating hormone. Proc. Natl. Acad. Sci. U.S.A. 88: 2763.
46. RIVEST, S., S. LEE, B. ATTARDI & C. RIVIER. 1993. The chronic intracerebroventricular infusion of interleukin-1β alters the activity of the hypothalamic-pituitary-gonadal axis of cycling rats: effect on LHRH and gonadotropin biosynthesis and secretion. Endocrinology 133: 2424.
47. KALRA, S. P. 1993. Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge. Endocr. Rev. 14: 507.
48. KNOBIL, E. & J. HOTCHKISS. 1988. The menstrual cycle and its neuroendocrine control. In The Physiology of Reproduction. E. Knobil & J. D. Neill, Eds. Raven Press. New York.
49. MELLON, P., J. WINDLE, P. GOLDSMITH, C. PADULA, J. L. ROBERTS & R. I. WEINER. 1990. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5: 1-10.
50. 1-1 GnRH neuronal cell line. Proc. Natl. Acad. Sci. U.S.A. 89: 1852-1855.
51. WETSEL, W. C. I., M. M. VALENÇA, I. MERCHENTHALER, Z. LIPOSITS, F. J. LÒPEZ, R. I. WEINER, P. L. MELLON & A. NEGRO-VILLAR. 1992. Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone secreting neurons. Proc. Natl. Acad. Sci. U.S.A. 89: 4149-4153.
52. KRSMANOVIC, L. Z., S. S. STOJILKOVIC, L. M. MERTZ, M. TOMIC & K. J. CATT. 1993. Expression of gonadotropin-releasing hormone receptors and autocrine regulations of neuropeptide release in immortalized hypothalamic neurons. Proc. Natl. Acad. Sci. U.S.A. 90: 3908-3912.
53. HATTON, G. I., L. S. PERLMUTTER, A. K. SALM & C. D. TWEEDLE. 1984. Dynamic neuronal-glial interactions in hypothalamus and pituitary: implications for control of hormone synthesis and release. Peptides [Suppl. 1] 5: 121.
54. MARCHETTI, B., J. J. REEVES, G. PELLETIER & F. LABRIE. 1988. Modulation of pituitary luteinizing hormone-releasing hormone receptors by sex steroids and LHRH in the rat. Biol. Reprod. 27: 133.
55. MARCHETTI, B. & F. LABRIE. 1982. Prolactin inhibits pituitary LHRH receptors in the rat. Endocrinology 111: 1209.
56. MARCHETTI, B. & U. SCAPAGNINI. 1985. Modulation of opioid influence on pituitary luteinizing hormone-releasing hormone receptors in the female rat. Neuroendocrinol. Lett. 7: 11-18.
57. HSUEH, A. J. W. & P. B. C. JONES. 1981. Extrapituitary actions of gonadotropin-releasing hormone. Endocr. Rev. 2: 437.
58. LABRIE, F., C. SÉGUIN, F. A. LEFEBVRE, J. J. REEVES, A. BELANGER, J. MASSICOTTE, L. CUSAN, P. A. KELLY & B. MARCHETTI. 1982. Gonadal LHRH receptors and direct gonadal effects of LHRH agonist. In Frontiers in Hormone Research Advances in Neuroendocrine Physiology. G. Tolis & K. B. Ruf, Eds.: 33. Karger. Basel.
59. TREMBLAY, Y., A. BELANDER & B. MARCHETTI. 1985. Specificity of the direct effect of an LHRH agonist on testicular 17-hydroxylase, but not on 5α-reductase activity in hypophysectomized adult rats. Mol. Cell. Endocrinol. 40: 33.
60. MARCHETTI, B., G. PALUMBO, E. CITTADINI, A. CIANCI, R. PALERMO, E. LOMEO, S. CIANCI & U. SCAPAGNINI. 1987. LHRH receptors in human ovary and corpus luteum: possible role in the intragonadal regulation of human reproductive function. In Proc. 12th World Congr. Fertil. Steril.: Releasing Hormones and Genetics and Immunology in Human Reproduction. E-S. Teoh, S. S. Ratnam & V. H. H. Goh, Eds.: 43. Parthenon. Lancaster, United Kingdom.
61. KHODR, G. S. &. T. M. SILER-KHODR. 1978. Localization of luteinizing hormone-releasing factor (LRF) in the human placenta. Fertil. Steril. 29: 523.
62. KHODR, G. S. & T. M. SILER-KHODR. 1980. Placental LRF and its synthesis. Science 227: 315.
63. KOCH, Y. & T. BARAM. 1977. Gonadotropin-releasing hormone in milk. Science 207: 215.
64. SEPPALA, M., T. WAHLSTROM & J. LEPPALUOTO. 1979. Luteinizing hormone-releasing factor (LRF)-like immunoreactivity in rat pancreatic islet cells. Life Sci. 25: 1489.
65. CURRIE, A. J., H. M. FRASER & R. M. SHARPE. 1981. Human placental receptors for luteinizing hormone-releasing hormone. Biochem. Biophys. Res. Commun. 99: 332.
66. MAIER, C. C., B. MARCHETTI, R. D. LEBOEUF & J. E. BLALOCK. 1992. Thymocytes express an mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA. Cell. Mol. Neurobiol. 12: 447.
67. AZAD, N., N. V. EMANUELE, M. M. HALLORAN, J. TENTLER & M. R. KELLEY. 1991. Presence of luteinizing hormone-releasing hormone (LHRH) mRNA in rat spleen lymphocytes. Endocrinology 128: 1679.
68. AZAD, N., N. LA PAGLIA, K. ABEL, J. JURGENS, L. KIRSTEINS, N. V. EMANUELE, M. KELLEY, A. M. LAWRENCE & N. MOHAGHEGHPOUR. 1993. Immunoactivation enhances the concentation of luteinizing hormone-releasing hormone peptide and its gene expression in human peripheral T-lymphocytes. Endocrinology 133: 215.
69. BIRNBAUMER, L., N. SHAHABI, J. RIVIER & W. VALE. 1985. Evidence for a physiological role of gonadotropin-releasing hormone (GnRH) or GnRH-like material in the ovary. Endocrinology 116: 1367.
70. BILLIG, H., I. FURUTA & A. J. W. HSUEH. 1994. Gonadotropin-releasing hormone directly induces apoptotic cell death in the rat ovary: biochemical and in situ detection of deoxyribonucleic acid fragmentation on granulosa cells. Endocrinology 134: 245.
71. HUGHES, F. M. & W. C. GOROSPE. 1991. Biochemical identification of apoptosis (programmed cell death) in granulosa cells: evidence for potential mechanisms underlying follicular atresia. Endocrinology 129: 2415.
72. MILLER, W. R., W. N. SCOTT, R. MORRIS, H. M. FRASER & R. M. SHARPE. 1985. Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist. Nature 313: 231.
73. EIDNE, K. A., C. A. FLANAGAN & R. P. MILLAR. 1987. Gonadotropin-releasing hormone (GnRH) binding sites in human breast cancer cell lines and inhibitory effects of GnRH antagonists. J. Clin. Endocrinol. Metab. 64: 425-432.
74. LAMBERTS, S. W. J., J. M. TIMMERS, R. OOSTEROM, T. VERLEUN, F. G. ROMMERO & F. H. DE JONG. 1982. Testosterone secretion by cultured arrhenoblastoma cells: suppression by a luteinizing hormone agonist. J. Clin. Endocrinol. Metab. 54: 450-454.
75. PAHWA, G. S., G. VOLLMER, R. KNUPPEN & G. EMONS. 1989. Photoaffinity labeling of gonadotropin-releasing hormone binding sites in human epithelial ovarian carcinomata. Biochem. Biophys. Res. Commun. 161: 1086-1092.
76. EMONS, G., O. ORTMANN, G. S. PAHWA, R. KACKENBERG, F. OBERHEUS & K. D. SCHULTS. 1992. Intracellular actions of gonadotropic peptide hormones and the therapeutic value of GnRH-agonists in ovarian cancer. Acta Obstet. Gynecol. Scand. 155: 31-38.
77. FEKETE, M., T. W. REDDING, A. M. COMRARU-SCHALLY, J. E. PONTES, R. W. CONNELEY, G. SRKALOVIC & A. V. SCHALLY. 1989. Receptors for luteinizing hormone-releasing hormone, somatostatin, prolactin, and epidermal growth factor in rat and human prostate cancers and in benign prostate hyperplasia. Prostate 14: 191-208.
78. QAYUM, A., W. GULLICK, R. C. CLAYTON, K. SIKORA & J. WAXMAN. 1992. The effects of gonadotropin-releasing hormone analogues in prostate cancer are mediated through specific tumour receptors. J. Cancer 62: 96-99.
79. MARCHETTI, B., V. GUARCELLO, M. C. MORALE, G. BARTOLONI, Z. FARINELLA, S. CORDARO & U. SCAPAGNINI. 1989. Luteinizing hormone-releasing hormone (LHRH) binding sites in the rat thymus: characteristic and biological function. Endocrinology 125: 1025.
80. MARCHETTI, B., V. GUARCELLO, M. C. MORALE, G. BARTOLONI, F. RAITI, G. PALUMBO, JR., Z. FARINELLA, S. CORDARO & U. SCAPAGNINI. 1989. Luteinizing hormone-releasing hormone (LHRH) agonist restoration of age-associated decline of thymus weight, thymic LHRH receptors, and thymocyte proliferative capacity. Endocrinology 125: 1037.
81. MARCHETTI, B., V. GUARCELLO & U. SCAPAGNINI. 1988. Luteinizing hormone-releasing hormone agonist (LHRH-A) binds to lymphocytes and modulates the immune response. In Biology and Biochemistry of Normal and Cancer Cell Growth. L. Castagnetta & I. Nenci, Eds.: 149. Harwood Academic Press. London.
82. STANDAERT, F. E., B. P. CHEW, D. DE AVILA & J. J. REEVES. 1992. Presence of luteinizing hormone-releasing hormone binding sites in cultured porcine lymphocytes. Biol. Reprod. 46: 997.
83. ATAYA, K. M., W. SAKR, C. M. BLACKER, M. A. MUTCHNICK & Z. A. LATIF. 1989. Effect of GnRH agonists on the thymus in female rats. Acta Endocrinol. 121: 833.
84. BLACKER, C. M., K. M. ATAYA, R. T. SAVOY-MOORE, M. G. SUBRAMANIAN, M. A. MUTCHNICK & J. DUNBAR. 1991. The gonadotropin-releasing hormone agonist leuprolide affects the thymus and other non-reproductive systems of female rats. Acta Endocrinol. 125: 581.
85. RAO, L. V., R. P. CLEVELAND & K. M. ATAYA. 1993. Sequential changes in functional lymphocyte subpopulations during long-term administration of GnRH agonist in postpubertal female mice. Endocr. J. 1: 451.
86. CHIODI, H. 1977. Thymus hypertrophy induced by castration in old rats and mice. Fed. Proc. 35: 277A.
87. GREENSTEIN, B. D., F. T. A. FITZPATRICK, M. D. KENDALL & M. J. WHEELER. 1987. Regeneration of the thymus in old male rats treated with a stable analogue of LHRH. J. Endocrinol. 112: 345.
88. MARCHETTI, B., V. GUARCELLO, M. C. MORALE, G. BARTOLONI, G. PALUMBO, F. RAITI, N. CUTULI, Z. FARINELLA & U. SCAPAONINI. 1990. A physiological role for the neuropeptide luteinizing hormone-releasing hormone (LHRH) during the maturation of thymus gland function. Int. J. Neurosci. 51: 287.
89. MORALE, M. C., N. BATTICANE, G. BARTOLONI, V. GUARCELLO, Z. FARINELLA, M. G. GALASSO & B. MARCHETTI. 1991. Blockade of central and peripheral luteinizing hormone-releasing hormone (LHRH) receptors in neonatal rats with a potent LHRH-antagonist inhibits the morphofunctional development of the thymus and maturation of cell-mediated and humoral immune responses. Endocrinology 128: 1073.
90. JACOBSON, J. D., B. C. NISULA & A. D. STEINBERG. 1994. Modulation of the expression of murine lupus by gonadotropin-releasing hormone analogs. Endocrinology 134: 2516.
91. GLASS, J. D. 1991. A sequence related to the human gonadoliberin precursor near the N-termini of HIV and SIV gag polyproteins. J. Theor. Biol. 150: 489-496.
92. GOTTSCHALL, P. E., A. UEHARA, S. T. HOFFMAN & A. ARIMURA. 1987. Interleukin-1 inhibits FSH-induced differentiation in rat granulosa cells in vitro. Biochem. Biophys. Res. Commun. 149: 502.
93. FUKUOKA, M., T. MORI, S. TAII & K. YASUDA. 1988. Interleukin-1 inhibits luteinization of porcine granulosa cells in culture. Endocrinology 122: 367.
94. HERNANDEZ, E. R. & E. Y. ADASHI. 1991. Cytokine-mediated regulation of ovarian function: interleukin-1 inhibits gonadotropin-induced androgen biosynthesis. Endocrinology 129: 1250.
95. KOKIA, E., A. HURWITZ, E. RICCIARELLI, C. TEDESCHI, C. RESNICK, M. MITCHELL & E. Y. ADASHI. 1992. Interleukin-1 stimulates ovarian prostaglandin biosynthesis: evidence for cell-cell interaction. Endocrinology 130: 3095.
96. HURWITZ, A., J. LOUKIDES, E. RICCIARELLI, L. BOTERO, E. KATZ, J. M. MCALLISTER, J. E. GARCIA, R. ROHAN, E. Y. ADASHI & E. R. HERNANDEZ. 1992. The human intraovarian interleukin-1 (IL-1), its receptor, and its receptor antagonist. J. Clin. Invest. 89: 1745.
97. HURWITZ, A., E. RICCIARELLI, L. BOTERO, E. R. HERNANDEZ & E. Y. ADASHI. 1991. Endocrine- and autocrine-mediated regulation of rat ovarian (theca-interstitial) interleukin-1β gene expression: gonadotropin-dependent preovulatory acquisition. Endocrinology 129: 3427.
98. HURWITZ, A., M. DUSHNIK, H. SOLOMON, A. BEN-CHETRIT, Z. FINCI-YEHESKEL, A. MILWIDSKY, M. MAYER, E. Y. ADASHI & S. YAGEL. 1993. Cytokine-mediated regulation of rat ovarian function: interleukin-1 stimulates the accumulation of a 92-kilodalton gelatinase. Endocrinology 132: 2709.
99. GROSSMAN, C. J. 1984. Regulation of the immune system by sex steroids. Endocr. Rev. 5: 435.
100. MARCHETTI, B., F. GALLO, Z. FARINELLA & M. C. MORALE. 1995. Unique neuroendocrine-immune interactions during pregnancy. In The Physiology of Immunity. M. Kendal & J. Marsh, Eds. CRC Press. Boca Raton, Florida.
101. MARCHETTI, B. 1989. Involvement of the thymus in reproduction. Prog. Neuroendocrinimmunol. 2: 64.
102. GROSSMAN, C. J. 1990. Are there underlying immune-neuroendocrine interactions responsible for immunological sexual dimorphism? Prog. Neuroendocrinimmunol. 3: 75.
103. FAROOKHI, R., E. WESOLOWSKI, J. M. TRASLER & B. ROBAIRG. 1988. Modulation by neonatal thymectomy of the reproductive axis in male and female rats during development. Biol. Reprod. 27: 1267.
104. MARCHETTI, B., M. C. MORALE, V. GUARCELLO, N. CUTULI, F. RAITI, N. BATTICANE, G. PALUMBO, JR., Z. FARINELLA & U. SCAPAGNINI. 1990. Crosstalk communication in the neuroendocrine-reproductive axis: age-dependent alterations in the common communication networks. Ann. N.Y. Acad. Sci. 594: 309.
105. GESHWIND, N. & P. O. BEHAN. 1982. Left-handedness: association with immune diseases, migraine, and developmental learning disorder. Proc. Natl. Acad. Sci. U.S.A. 79: 5097.
106. MARCHETTI, B., M. C. MORALE, V. GUARCELLO, N. CUTULI, F. GALLO & U. SCAPAGNINI. 1990. The neuroendocrine-immune connections in the control of reproductive functions. In Major Advances in Human Female Reproduction. Volume 73. E. Y. Adashi & S. Mancuso, Eds.: 279. Raven Press. New York.
107. MARCHETTI, B., M. C. MORALE, N. BATTICANE, F. GALLO, Z. FARINELLA & M. CIONI. 1991. Aging of the reproductive-neuroimmune axis: a crucial role for the hypothalamic neuropeptide luteinizing hormone-releasing hormone. Ann. N.Y. Acad. Sci. 621: 159.
108. 2-adrenergic receptor in the rat thymus gland and presence of a sexual dimorphism during ontogenic development. Prog. Neuroendocrinimmunol. 3: 103.
109. 2-adrenergic receptor distribution as revealed by in vitro autoradiography. Mol. Cell. Neurosci. 1: 10.
110. 2-adrenergic receptor messenger RNA concentration in the male rat thymus. Mol. Endocrinol. 6: 1513.
111. 2-adrenergic receptor. Am. J. Physiol. 43: E718-E731.
112. MARCHETTI, B., A. PEIFFER, M. C. MORALE, N. BATTICANE, F. GALLO & N. BARDEN. 1994. Transgenic animals with impaired type II glucocorticoid receptor expression: a model to study aging of the neuroendocrine immune system. Ann. N.Y. Acad. Sci. 719: 308.
113. PEIFFER, A., M. C. MORALE, N. BARDEN & B. MARCHETTI. 1994. Modulation of glucocorticoid receptor gene expression in the thymus by the sex steroid hormone milieu and correlation with sexual dimorphism of immune response. Endocr. J. 2: 181.
114. MORALE, M. C., N. BATTICANE, F. GALLO, N. BARDEN & B. MARCHETTI. 1995. Disruption of hypothalamic-pituitary-adrenocortical system in transgenic mice expressing type II glucocorticoid receptor antisense RNA permanently impairs T-cell function: effects on T-cell trafficking and T-cell responsiveness during postnatal development. Endocrinology 136: 3949-3960.
115. RADIVICK, S., C. M. TICKNOR, Y. NAKAYAMA, A. C. NOTIDES, A. RAHMAN, B. D. WEINTRAUB, G. B. CUTTLER & F. E. WONDISFORD. 1991. Evidence for direct estrogen regulation of the human gonadotropin-releasing hormone gene. J. Clin. Invest. 88: 1649.
116. MARCHETTI, B., M. C. MORALE, F. GALLO, N. BATTICANE, Z. FARINELLA & M. CIONI. 1995. Neuroendocrine immunology (NEI) at the turn of the century: towards a molecular understanding of basic mechanisms and implications for reproductive physiopathology. Endocrine 3: 845-861.
117. GALLO, F., M. C. MORALE, D. SAMBATARO, Z. FARINELLA, U. SCAPAGNINI & B. MARCHETTI. 1993. The immune system response during development and progression of carcinogen-induced rat mammary tumors: prevention of tumor growth and restoration of immune system responsiveness by thymopentin. Breast Cancer Res. Treat. 27: 221-237.