Efficacy of combination therapy with amantadine, thymosin α1 and α/β interferon in mice infected with influenza A virus

International Journal of Immunopharmacology

Volumn 18, Issue 2, 1996, Pages 95-102

  D'Agostini, Cartesio ^a   Palamara, Anna Teresa ^a   Favalli, Cartesio ^a,b   Sivilia, Mariliana ^a   Febbraro, Giuseppe ^a   Bue', Cristina ^a   Garaci, Enrico ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Amantadine; Combination therapy; Influenza; Thymosin 1; interferon

Indexed keywords

ALPHA INTERFERON BETA; AMANTADINE; THYMOSIN ALPHA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; IMMUNOMODULATION; INFLUENZA VIRUS A; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0030012884     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/0192-0561(96)00002-1     Document Type: Article

References (36)

1. Ada, G. L. & Jones, P. D. (1986). The immune response to influenza infection. Current Topics in Microbiology and Immunology, 128, 2-54.
2. Barrett, T. & Inglis, S. C. (1985). Growth, purification and titration of influenza virus. In Virology: A Pratical Approach (ed. Mahy, B. W. J.), pp. 119-150. IRL Press, Oxford.
3. Buckley, C. E. III, Zitt, M. G. & Cate, T. R. (1973). Two categories of lymphocyte unresponsiveness to phytohemagglutinin. Cell. Immun., 6, 140-148.
4. Bukowsky, J. F., Warner, J. F., Dennert, G. & Welsh, R. M. (1985). Adoptive transfer studies demonstrating the antiviral effects of natural killer cells in vivo. J. exp. Med., 161, 40-52.
5. Davies, W. L., Grunert, R. R., Haff, R. F., McGahen, J. W., Neumayer, E. M., Pauloshock, M., Watts, J. C., Wood, T. R., Hermann, E. C. & Hoffmann, C. E. (1964). Antiviral activity of 1-Adamantanamine (Amantadine). Science, 144, 862-863.
6. Del Gobbo, V., Villani, N., Marini, S., Balestra, E. & Calio', R. (1990). Suppressor cells induced by influenza virus inhibit interleukin-2 production in mice. Immunology, 69, 454-459.
7. Dolin, R., Reichman, R. C., Madore, H. P., Maynard, R., Linton, R. L. & Webber-Jones, J. (1982). A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infections. N. Engl. J. Med., 307, 580-584.
8. Favalli, C., Jezzi, T., Mastino, A., Rinaldi-Garaci, C., Riccardi, C. & Garaci, E. (1985). Modulation of natural killer activity by thymosin alpha 1 and interferon. Cancer Immun. Immunother., 20, 189-92.
9. Favalli, C., Mastino, A., Jezzi, T., Grelli, S., Goldstein, A. L. & Garaci, E. (1989). Synergistic effect of thymosin α1 and α/β-interferon on NK activity in tumor-bearing mice. Int. J. Immunopharmac., 11, 443-450.
10. Frasca, D., Adorini, L., Mancini, C. & Doria, G. (1988). Reconstitution of T-cell function in aging mice by thymosin alpha 1. Immunopharmacology, 11, 55-68.
11. Garaci, E., Mastino, A., Pica, F. & Favalli, C. (1990). Combination treatment using thymosin α1 and interferon after cyclophosphamide is able to cure Lewis lung carcinoma in mice. Cancer Immun. Immunother., 32, 154-160.
12. Garaci, E., Pica, F., Mastino, A., Palamara, A. T., Belardelli, F. & Favalli, C. (1993). Antitumor effect of thymosin α1/interferon α/β following cyclophosphamide in mice injected with highly metastatic Friend erythroleukemia cells. J. Immunother., 13, 7-17.
13. Garaci, E., Rocchi, G., Perroni, L., D'agostini, C., Soscia, F., Grelli, S., Mastino, A. & Favalli, C. (1994). Combination treatment with zidovudine, thymosin α1 and interferon-α in human immunodeficiency virus infection. Int. J. clin. Lab. Res., 24, 23-28.
14. Goldstein, A. L., Low, T. L. K., Adoo, M., McClure, J., Thurman, G. B., Rossio, G., La, C. Y., Chang, D., Wang, S. S., Harwey, C., Ramel, A. H. & Meienhofer, J. (1977). Thymosin alpha 1: isolation and sequence analysis of an immunologically active thymic polypeptide. Proc. natn. Acad. Sci. U.S.A., 74, 725-729.
15. Grunert, R. R. & Hoffman, C. E. (1977). Sensitivity of influenza A/New Jersey/8/76 (Hsw1 N1) virus to amantadine HCL. J. infect. Dis., 136, 297-300.
16. Hay, A. J., Wolstenholme, J. J., Skehel, J. J. & Smith, M. H. (1985). The molecular basis of the specific anti-influenza action of amantadine. EMBO J., 11, 3021-3024.
17. Herberman, R. B. (1985). Natural killer (NK) cells: characteristics and possible role in resistance against tumor growth. In Immunity to Cancer (eds Reif, A. E. and Mitchell, M. S.), pp. 217-219. Academic Press, Orlando.
18. Jakab, G. J., Warr, G. A. & Knight, M. E. (1979). Pulmonary and systemic defenses against challenge with Staphylococcusaureus in mice with pneumonia due to influenza A virus. J. infect. Dis., 140, 105-108.
19. + cytotoxic T-cells. Immunology, 67, 375-380.
20. Mastino, A., Favalli, C., Grelli, S., Innocenti, F. & Garaci, E. (1991a). Thymosin α1 potentiates interleukin-2 induced cytotoxic activity in mice. Cell. Immun., 133, 196-205.
21. Mastino, A., Grelli, S., Premrov, M. G. & Favalli, C. (1991b). Susceptibility to influenza A virus infection in mice immunosuppressed with Cyclophosphamide. J. Chemother., 3, 156-161.
22. Mitchell, D. M., McMichael, A. J. & Lamb, J. R. (1985). The immunology of influenza. Br. med. Bull., 41, 80-85.
23. Riccardi, C., Vose, B. M. & Herberman, R. B. (1983). Modulation of IL-2 dependent growth of mouse NK cells by interferon and T-lymphocytes. J. Immun., 130, 228-236.
24. Roberts, N. J., Jr & Domurat, F. (1989). Virus-induced immunosuppression: influenza virus. In Virus-induced Immunosuppression (eds Specter, S., Bendinelli, M. and Friedman, H.), pp. 303-326. Plenum Press, New York.
25. Rodriguez-Boulan, E. (1983). Polarized assembly of enveloped viruses from cultured epithelial cells. Meth. Enzymol., 98, 486-501.
26. Santoro, M. G., Favalli, C., Mastino, A., Jaffe, B. M., Esteban, M. & Garaci, E. (1988). Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus. Arch. Virol., 99, 89-100.
27. Scheinberg, M. A., Blacklow, N. R., Goldstein, A. L., Parino, T. A., Rose, F. B. & Cathcart, E. S. (1976). Influenza: response of T-cell lymphopenia to thymosin. N. Engl. J. Med., 294, 1208-1211.
28. Serrate, S. A., Schulof, R. S., Leonardis, L., Goldstein, A. L. & Sztein, M. B. (1987). Modulation of human natural killer cell cytotoxic activity, lymphokine production, and interleukin-2 receptor expression by thymic hormones. J. Immun., 139, 2338-2347.
29. Stein-Streilein, J., Bennett, D. M. & Kumar, V. (1983). Natural killer cells in mouse lungs: surface phenorype preference, and response to local influenza virus infection. J. Immun., 131, 2699-2704.
30. Stein-Streilein, J. & Guffee, J. (1986). In vivo treatment of mice and hamsters with antibodies to asialo GM1 increases morbidity and mortality to pulmonary influenza infection. J. Immun., 136, 1435-1441.
31. Stein-Streilein, J., Write, P. L., Streilein, J. W. & Guffee, J. (1985). Local cellular defenses in influenza infected lungs. Cell. Immun., 95, 234-242.
32. Sztein, M. B., Serrate, S. A. & Goldstein, A. L. (1986). Modulation of interleukin 2 receptor expression on normal human lymphocytes by thymic hormones. Proc. natn. Acad. Sci. U.S.A., 83, 6107-6112.
33. Warshauer, D., Goldstein, E., Aker, T., Lippert, W. & Kim, M. (1977). Effect of influenza viral infection on the ingestion and killing of bacteria by alveolar macrophages. Am. Rev. resp. Dis., 115, 269-277.
34. Yap, K. L. & Ada, G. L. (1978). Cytotoxic T-cells in the lungs of mice infected with an influenza A virus. Scand. J. Immun., 7, 73-80.
35. Yap, K. L., Ada, G. L. & Mackenzie, C. D. (1978). Transfer of specific cytotoxic T-lymphocytes protects mice inoculated with influenza virus. Nature., 273, 238-239.
36. Zatz, M. M., Oliver, J., Samuels, C., Skotnicki, A. B., Sztein, M. B. & Goldstein, A. L. (1985). Thymosin increases production of T-cell growth factor by normal human peripheral blood lymphocytes. Proc. natn. Acad. Sci. U.S.A., 81, 2882-2886.