Combined effect of penetration enhancers and temperature on skin irritation in rats

S.T.P. Pharma Sciences

Volumn 6, Issue 2, 1996, Pages 142-147

  Ohara, N ^a   Takayama, K ^a   Isowa, K ^b   Nagai, T ^a  

^a HOSHI UNIVERSITY   (Japan)

^b Ctr of Japan Biol Chem Co Ltd   (Japan)

Author keywords

D limonene; Oleic acid; Skin irritation; Skin penetration enhancer; Temperature effect

Indexed keywords

LIMONENE; OLEIC ACID;

ANIMAL EXPERIMENT; ARTICLE; DRUG FORMULATION; HISTOPATHOLOGY; HYDROGEL; MALE; NONHUMAN; RAT; SKIN IRRITATION; SKIN PENETRATION; TEMPERATURE;

EID: 0030012754     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. OHARA N., TAKAYAMA K., MACHIDA Y. and NAGAI T. - Combined effect of d-limonene and temperature on the skin permeation of ketoprofen. - Int. J. Pharm., 105, 31-38, 1994.
2. OHARA N., TAKAYAMA K. and NAGAI T. - Combined effect of d-limonene pretreatment and temperature on the rat skin permeation of lipophilic and hydrophilic drugs. - Biol. Pharm. Bull., 18, 439-442, 1995.
3. OHARA N., TAKAYAMA K. and NAGAI T. - Influence of temperature on the percutaneous absorption for lipophilic and hydrophilic drugs across the rat skin pretreated with oleic acid. - Int. J. Pharm., in press, 1995.
4. GREEN P. G., GUY R.H. and HADGRAFT J. - In vitro and in vivo enhancement of skin permeation with oleic and lauric acid. - Int. J. Pharm., 48, 103-111, 1988.
5. FRANCOEUR M.L. GOLDEN G.M. and POTTS R.O. - Oleic acid : its effects on stratum corneum in relation to (trans)dermal drug delivery. - Pharm. Res., 7, 621-627, 1990.
6. KOYAMA Y , BANDO H., YAMASHITA F., TAKAKURA Y., SEZAKI H. and HASHIDA M. - Comparative analysis of percutaneous absorption enhancement by d-limonene and oleic acid based on a skin diffusion model - Pharm. Res , 11, 377-383, 1994.
7. RULAND A., KREUTER J. and RYTTING J.H. - Transdermal delivery of the tetrapeptide hisetal (melanotropin (6-9)). I Effect of various penetration enhancers : in vitro study across hairless mouse skin. - Int J. Pharm., 101, 57-61, 1994.
8. RULAND A., KREUTER J. and RYTTING J.H. - Transdermal delivery of the tetrapeptide hisetal (melanotropin (6-9)). II. Effect of various penetration enhancers : in vitro study across human skin - Int. J. Pharm., 103, 77-80. 1994.
9. OKABE H., TAKAYAMA K., OGURA A. and NAGAI T. - Effect of limonene and related compounds on the percutaneous absorption of indomethacin. - Drug Des. Del., 4, 313-321, 1989.
10. OBATA Y., TAKAYAMA K., OKABE H and NAGAI T. - Effect of cyclic monoterpenes on percutaneous absorption in the case of a water soluble drug (diclofenac sodium) - Drug Des. Del., 6. 319-328, 1990.
11. OKABE H, OBATA Y., TAKAYAMA K. and NAGAI T. - Percutaneous absorption enhancing effect and skin irritation of monocyclic monoterpenes. - Drug Des. Del., 6, 229-238, 1990.
12. OBATA Y., TAKAYAMA K., MACHIDA Y. and NAGAI T. - Combined effect of cyclic monoterpenes and ethanol on percutaneous absorption of diclofenac sodium. - Drug Des Del , 8, 137-144, 1991.
13. KIKUCHI K., TAKAYAMA K and NAGAI T - Effect of d-limonene on the amounts of ethanol and indomethacin penetrated from aqueous gel ointments to rat skin. - Chem. Pharm. Bull., 40, 3108-3109, 1992.
14. OBATA Y., TAKAYAMA K., MAITANI Y., MACHIDA Y. and NAGAI T. - Effect of pretreatment of skin with cyclic monoterpenes on permeation of diclofenac in hairless rat. - Biol. Pharm. Bull., 16, 312-314, 1993.
15. OKUM M. R. and EDELSTEIN L.M. - Gross and Microscopic Pathology of the Skin. - Dermatopathology Foundation Press, Boston, 1976, pp. 10-168.
16. CHIEN Y.W. - Transdermal controlled-release drug administration. - In : Novel Drug Delivery Systems, Marcel Dekker, New York, 1982, pp. 149-160.
17. MEHREGAN A.H. - Pinkus' Guide to Dermatohistopathology. - Appleton-Century-Crofts, Norwalk, 1986, pp. 77-92.
18. ELIAS P M. - Epidermal lipids, membranes, and keratinization. - Int. J. Dermatol., 20, 1-19, 1981.
19. BARRY B. W. - Action of skin penetration enhancers : the lipid-protein partitioning theory. - Int. J. Cosmet. Sci., 10, 281-293, 1988.
20. BARRY B.W. - Lipid-protein partitioning theory of skin penetration enhancement. - J. Contr. Rel., 15, 237-248, 1991.