Granulomatous cholangitis in chronic hepatitis C: A new diagnostic problem in liver pathology

Pathology International

Volumn 46, Issue 4, 1996, Pages 301-305

  Hoso, Masahiro ^a   Nakanuma, Yasuni ^a   Kawano, Mitsuhiro ^b   Oda, Kunio ^b   Tsuneyama, Koichi ^a,c   Van Water, Judy De ^c   Gershwin, M Eric ^c  

^a KANAZAWA UNIVERSITY   (Japan)

^b Naruwa General Hospital   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antimitochondrial antibodies; chronic hepatitis C; granulomatous cholangitis; primary biliary cirrhosis

Indexed keywords

ALKALINE PHOSPHATASE; IMMUNOGLOBULIN M; MITOCHONDRION ANTIBODY;

ADULT; ARTICLE; CASE REPORT; CHOLANGITIS; CHRONIC HEPATITIS; FEMALE; GRANULOMATOUS INFLAMMATION; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; PRIORITY JOURNAL;

EID: 0030012748     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1827.1996.tb03615.x     Document Type: Article

References (22)

1. Sherlock S. Disease of the Liver and Biliary System, 8th edn. Blackwell Scientific Publications, 1989.
2. Klaskin G, Conn HO. Histopathology of the Liver. Oxford University Press, New York, Oxford, Vol. 1, 1993.
3. Jyberg M. The hepatitis-associated bile duct lesion. Liver 1994; 13: 289-301.
4. Lefkowitch JH, Schiff ER, Davis GL et al. Pathological diagnosis of chronic hepatitis C: A multicenter comparative study with chronic hepatitis B. Gastroenterology 1993; 104: 595-603.
5. Bach N, Thung SN, Schaffner F. The histological features of chronic hepatitis C and autoimmune chronic hepatitis: A comparative analysis. Hepatology 1992; 15: 572-577.
6. Nakanuma Y, Kono N. Expression of HLA-DR antigens on interlobular bile ducts in primary biliary cirrhosis and other hepatobiliary diseases: An immunohistochemical study. Hum. Pathol. 1991; 22: 431-436.
7. Van de Water J, Turchany J, Leung PSC et al. Molecular mimicry in primary biliary cirrhosis. Evidence for biliary expression of a molecule cross-reactive with pyruvate dehydrogenase complex E. J. Clin. Invest. 1993; 91: 2653-2664.
8. Gerber MA, Krawczynski K, Alter MJ, Sampliner RE, Margelis HS. The sentinel counties chronic non-A non-B hepatitis study team. Histopathology of community acquired chronic hepatitis. Mod. Pathol. 1992; 5: 483-486.
9. Rowan BP, Smith A, Gleeson D, Hunt LP, Warness TW. Hepatitis C virus in autoimmune liver disease in the UK: Aetiological agent or artefact? Gut 1994; 35: 542-546.
10. Van de Water J, Gershwin ME. The molecular definition of the mitochondrial autoantigens of primary biliary cirrhosis. Bull. Inst. Pasteur 1989; 87: 349-359.
11. Fregeau DR, Roche TE, Davis PA, Coppel R, Gershwin ME. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1α, a non-lipoic acid containing mitochondrial enzyme. J. Immunol. 1990; 144: 1671-1676.
12. Van de Water J, Cooper A, Surh C et al. Detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary cirrhosis. N. Engl. J. Med. 1989; 320: 1377-1380.
13. Gershwin ME, Mackey I, Coppel R, Nakanuma Y. Clinical, immunological and molecular features of primary biliary cirrhosis. Sem. Clin. Immunol. 1994; 7: 5-16.
14. Ludwig J. The nomenclature of chronic hepatitis: an obituary. Gastroenterology 1993; 105: 274-278
15. Nakanuma Y, Karino T, Ohta G. Orcein positive granules in the hepatocytes in chronic cholestasis. Virchows Arch. A. Pathol. Anat. Histopathol. 1979; 382: 21-30.
16. Hsu M, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC in immunoperoxidase techniques: A comparison between ABC and unlabelled PAP procedures). J. Histochem. Cytochem. 1981; 29: 557-580.
17. Graham RC, Karnovsky MJ. The early stages of absorption of injected peroxidase in the proximal tubules of mouse kidney: Ultrastructural cytochemistry by a new technique. J. Histochem. Cytochem. 1966; 14: 291-302.
18. Kaji K, Nakanuma Y, Tsuneyama K, Van de Water J, Gershwin ME. Hepatitic bile duct injury in chronic hepatitis C: Histopathologic and immunohistochemical studies. Mod. Pathol. 1994; 7: 937-945.
19. Nakanuma Y, Ohta G. Quantitation of hepatic granulomas and epithelioid cells in primary biliary cirrhosis. Hepatology 1983; 3: 423-427.
20. Danque POV, Bach N, Schaffner F, Gerber MA, Thung SN. HLA-DR expression in bile duct damage in hepatitis C. Mod. Pathol. 1993; 6: 327-332.
21. Gerber MA. Pathology of hepatitis C virus. Jpn. J. Gastroenterol. 1994; 91: 463-465.
22. Emile JF, Sebagh M, Feray C, David F, Reynes M. The presence of epithelioid granulomas in hepatitis C virus-related cirrhosis. Hum. Pathol. 1993; 24: 1095-1097.