Inhibitory effects of diltiazem, an L-type Ca2+ channel blocker, on naloxone-increased glutamate levels in the locus coeruleus of opioid-dependent rats

Brain Research

Volumn 722, Issue 1-2, 1996, Pages 212-216

  Tokuyama, Shogo ^a   Ho, Ing K ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Butorphanol; Channels; Diltiazem; Glutamate; L type Ca2+; Locus coeruleus; Microdialysis; Morphine; Physical dependence

Indexed keywords

BUTORPHANOL; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; GLUTAMIC ACID; MORPHINE; NALOXONE;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DEPENDENCE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LOCUS CERULEUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WITHDRAWAL SYNDROME;

ANIMALS; BUTORPHANOL; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; GLUTAMIC ACID; LOCUS COERULEUS; MALE; MICRODIALYSIS; MORPHINE; MORPHINE DEPENDENCE; NALOXONE; NARCOTIC ANTAGONISTS; OPIOID-RELATED DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0030012461     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00187-4     Document Type: Article

References (32)

1. Aghajanian, G.K., Tolerance of locus coeruleus neurons to morphine and suppression of withdrawal response by clonidine, Nature, 276 (1978) 186-188.
2. Aghajanian, G.K., Kogan, J.H. and Moghaddam, B., Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study. Brain Res., 636 (1994) 126-130.
3. Barrios, M. and Baeyens. J.M., Differential effects of L-type calcium channel blockers and stimulants on naloxone-precipitated withdrawal in mice acutely dependent on morphine, Psychopharmacology, 104 (1991) 397-403.
4. Bhargava, H.N., The effects of divalent ions on morphine analgesia and abstinence syndrome in morphine-tolerant and -dependent mice, Psychopharmacology, 57 (1978) 223-225.
5. Caro, G., Barrios, M. and Baeyens, J.M., Dose-dependent and stereo-selective antagonism by diltiazem of naloxone-precipitated morphine abstinence after acute morphine-dependence in vivo and in vitro, Life Sci., 43 (1988) 1523-1527.
6. Crain, S.M. and Shen, K.-F., After brief GM1 ganglioside treatment of sensory neurons naloxone paradoxically prolongs the action potential but still antagonizes opioid inhibition, J. Phannacol. Exp. Ther., 260 (1992) 182-186.
7. Crain, S.M. and Shen, K.-F., After chronic opioid exposure sensory neurons become supersensitive to the excitatory effects of opioids agonists and antagonists as occurs after acute elevation of GM1 ganglioside. Brain Res., 575 (1992) 13-24.
8. Crain, S.M. and Shen, K.-F., Chronic morphine-treated sensory ganglion neurons remain supersensitive to the excitatory effects of naloxone for months after return to normal culture medium: an in vitro model of 'protracted opioid dependence'. Brain Res., 694 (1995) 103-110.
9. Dahlstrom, A. and Fuxe, L., Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons, Acta Physiol. Scand., 62 (1964) Suppl. 232 (1).
10. Esposito, E., Kruszzewska, A., Ossowska, G. and Samanin, R., Noradrenergic and behavioural effects of naloxone injected in the locus coeruleus of morphine-dependent rats and their control by clonidine, Psychopharmacology, 93 (1987) 393-396.
11. Feng, Y.Z., Zhang, T., Rockhold, R.W. and Ho, I.K., Increased locus coeruleus glutamate levels are associated with naloxone-precipitated withdrawal from butorphanol in the rat, Neurochem. Res., 20 (1995) 745-751.
12. Feng, Y.Z., Zhang, T., Tokuyama, S., Zhu, H., Rockhold, R.W. and Ho, I.K., μ- and δ-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence, Neurochem. Res., 21 (1996) 63-71.
13. Foote, S.L., Bloom, F.E. and Aston-Jones, G., Nucleus locus coeruleus: new evidence of anatomical and physiological specificity, Physiol. Rev., 63 (1983) 844-914.
14. Maldonado, R., Stinus, L., Gold, L.H. and Koob, G.F., Role of different brain structures in the expression of the morphine physical withdrawal syndrome, J. Pharm. Exp. Ther., 261 (1992) 669-677.
15. Nishi, K., Akaike, N., Oyama, Y. and Ito, H., Actions of calcium antagonists on calcium currents in helix neurons: specificity and potency. Circ. Res., 52 (Suppl. I) (1983) 53-59.
16. North, R.A., Drug receptors and the inhibition of nerve cells, Br. J. Pharmacol., 98 (1989) 13-28.
17. 3H]nitrendipine binding and γ-aminobutyric acid release in rat hippocampus following repeated morphine administration, J. Neurochem., 53 (1989) 1507-1511.
18. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxi Coordinates, 2nd edn., Academic Press, Orlando, FL, 1986.
19. Rasmussen, K. and Aghajanian, G.K., Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis, Brain Res., 505 (1989) 346-350.
20. Rasmussen, K., Beitner-Johnson, D.B., Krystal, J.H., Aghajanian, G.K. and Nestler, E.J., Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological and biochemical correlates, J. Neurosci., 10 (1990) 2308-2317.
21. Redmond, D.E. and Krystal, J.H., Multiple mechanisms of withdrawal from opioid drugs, Annu. Rev. Neurosci., 1 (1984) 443-478.
22. Redmond, D.E., Huang, Y.H., Snyder, D.R. and Maas, J.W., Behavioral effects of stimulation of the nucleus locus coeruleus in the stump-tailed monkey (Macaca arctoides), Brain Res., 116 (1976) 502-510.
23. + channel openers inhibit morphine withdrawal, Eur. J. Pharmacol., 251 (1994) 113-115.
24. Tempel, A. and Zukin, R.S., Neuroanatomical patterns of the μ, δ and κ opioid receptors of rat brain as determined by quantitative in vitro autoradiography, Proc. Natl. Acad. Sci. USA, 84 (1987) 4308-4312.
25. 2+ channel blocker, diltiazem, prevents physical dependence and the enhancement of protein kinase C activity by opioid infusion in rats, Eur. J. Pharmacol, 279 (1995) 93-98.
26. Tokuyama, S., Feng, Y.Z., Wakabayashi, H. and Ho, I.K., Possible involvement of protein kinase in physical dependence on opioids: studies using protein kinase inhibitors, H-7 and H-8. Eur. J. Phrmacol. 284 (1995) 101-107.
27. Tokuyama, S., Wakabayashi, H. and Ho, I.K., Direct evidence for a role of glutamate in the expression of the opioid withdrawal syndrome, Eur. J. Phrmacol., 295 (1996) 123-129.
28. Tsien, R.W., Lipscombe, D., Madison, D.V., Bley, K.R. and Fox, A.P., Multiple types of neuronal calcium channels and their selective modulation, Trends Neurosci., 11 (1988) 431-437.
29. Turner, T.J., Adams, M.E. and Dunlap, K., Calcium channels coupled to glutamate release identified by ω-Aga-IVA, Science, 258 (1992) 310-313.
30. 2+ channels. Naunyn-Schmiedeberg's Arch. Pharmacol., 337 (1988) 690-692.
31. 2+ channel function and drug action. Trends Pharmacol. Sci., 16 (1995) 43-49.
32. Zhang, T., Feng, Y.Z., Rockhold, R.W. and Ho, I.K., Naloxone-precipitated morphine withdrawal increases pontine glutamate levels in the rat, Life Sci., 55 (1994) 25-31.