Cellular resistance to the antimelanoma immunotoxin ZME-gelonin and strategies to target resistant cells

Cancer Immunology Immunotherapy

Volumn 42, Issue 2, 1996, Pages 115-121

  Rosenblum, Michael G ^a   Cheung, Lawrence ^a   Kim, Se Kyu ^a   Mujoo, Kalpana ^a   Donato, Nicholas J ^a   Murray, James L ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Chemotherapeutic agents; Drug resistance; Gelonin; Immunotoxins; Melanoma

Indexed keywords

ALPHA INTERFERON; ANTINEOPLASTIC AGENT; BACITRACIN; CARMUSTINE; CISPLATIN; COLCHICINE; ETOPOSIDE; FLUOROURACIL; GAMMA INTERFERON; GELONIN; IMMUNOTOXIN; LEUPEPTIN; MELPHALAN; NIGERICIN; PROPYLTHIOURACIL; UNCLASSIFIED DRUG; VERAPAMIL; ZINC OIL;

ARTICLE; DRUG RESISTANCE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; INTERNALIZATION; MELANOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL RESPONSE MODIFIERS; CELL MEMBRANE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMMUNOTOXINS; IODINE RADIOISOTOPES; KINETICS; MELANOMA; PLANT PROTEINS; TUMOR CELLS, CULTURED;

EID: 0030011912     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050260     Document Type: Article

References (35)

1. Banker DE, Pastan I, Gottesman MM, Herschman HR (1989) An epidermal growth factor-pseudomonos endotoxin (EGF-PE)-resistant mutant have distinct phenotypes. J Cell Physiol 139:51
2. Casellas P, Ravel S, Bourrie BJ, Derocq JM, Jansen FK, Laurent G, Gros P (1988) T-lymphocyte killing by T101-ricin A-chain immunotoxin: pH-dependent potentiation with lysosomotropic amines. Blood 72:1197
3. Donato NJ, Gallick GE, Steck PA, Rosenblum MG (1989) Tumor necrosis factor modulates EGF-receptor phosphorylation and kinase activity in human tumor cells: correlation with cytotoxicity. J Biol Chem 264:20474
4. Ferguson PJ (1991) The role of gene amplification in clinical resistance to chemotherapy: a review. J Otolaryngol 20:130
5. Fojo A, Hamilton TC, Young RC, Ozols RF (1987) Multidrug resistance in ovarian cancer. Cancer 60:2075
6. Fulton RJ, Uhr JW, Vitetta, ES (1986) The effect of antibody valency and lysosomotropic amines on the synergy between ricin A chain- and ricin B chain-containing immunotoxins. J Immunol 136:3103
7. Goldmacher VS (1988) Isolation and analysis of somatic cell mutants resistant to toxin conjugates. Cancer Treat Res 37:417
8. Goldmacher VS, Anderson J, Schulz ML, Blattler WA, Lambert JM (1987) Somatic cell mutants resistant to ricin, diphtheria toxin, and to immunotoxins. J Biol Chem 262:3205
9. Gonzalez-Noriega A, Coutino R, Saavedra VM, Barrera R (1989) Adsorptive endocytosis of lysosomal enzymes by human fibroblasts: presence of two different functional systems that deliver an acid hydrolase to lysosomes. Arch Biochem Biophys 268:649
10. Gottesman MM, Pastan I (1988) Resistance to multiple chemotherapeutic agents in human cancer cells. Trends Pharmacol Sci 9:54
11. Greiner JW, Smalley RV, Borden EC, Martin EW, Guadagni F, Roselli M, Schlom J (1991) Applications of monoclonal antibodies and recombinant cytokines for the treatment of human colorectal and other carcinomas. J Surg Oncol Suppl 2:9
12. Hall A, Cattan AR, Proctor SJ (1989) Mechanisms of drug resistance in acute leukaemia. Leukemia Res 13:351
13. Hamilton TC, Ozols RF, Longo DL (1987) Biologic therapy for the treatment of malignant common epithelial tumors of the ovary. Cancer 60:2054
14. Hertler AA, Frankel AE (1989) Immunotoxins: a clinical review of their use in the treatment of malignancies. J Clin Oncol 7:1932
15. Kornfeld SB, Leonard JE, Mullen MD, Taetle R (1991) Assessment of ligand effects in intracellular trafficking or ricin A chain using anti-ricin hybridomas. Cancer Res 51:1689
16. Lesly J, Schulte R (1986) Selection and characterization of transferrin receptor mutants using receptor-specific antibodies. Immunogenetics 24:163
17. Long BH, Stringfellow DA (1988) Inhibitors of topoisomerase II: structure-activity relationships and mechanism of action of podophyllin congeners. Adv Enzyme Regul 27:223
18. May RD, Wheeler HT, Finkelman FD, Uhr JW, Vitetta ES (1991) Intracellular routing rather than cross-linking or rate of internalization determines the potency of immunotoxins directed against different epitopes of sIgD on murine B cells. Cell Immunol 135:490
19. Miaskowski C (1991) Chemotherapy update. Nurs Clin North Am 26:331
20. Morgan AC Jr, Bordonaro J, Pearson JW, Sivam G (1987) Immunotoxins to a human melanoma-associated antigen: resistance to pokeweed antiviral portein conjugates in vitro. J Natl Cancer Inst 78:1101
21. 2. Cancer Immunol Immunother 34:198
22. Murray JL, Wilmanns C, Mujoo K, Janus MA, Rosenblum MG (1992) Factors influencing in vivo localizaton of radiolabeled antimelanoma monoclonal antibody combinations compared to single antibodies. Antibody Immunoconj, Radiopharm 5:209
23. Periti P, Mini E (1989) Drug resistance in cancer: an overview of the clinical aspects. J Chemother 1:5
24. Preijers FW, Tax WJ, Wessels JM, Capel PJ, DeWitte T, Haanen C (1988) Different susceptibilities of normal T cells and T cell lines to immunotoxins. Scand J Immunol 27:533
25. Press OW, DeSantes K, Anderson SK, Geissler F (1990) Inhibition of catabolism of radiolabeled antibodies by tumor cells using lysosomotropic amines and carboxylic ionophores. Cancer Res 50:1243
26. Rosenblum MG, Murray JL, Cheung L, Rifkin R, Salmon S, Bartholomew R (1991) A specific and potent immunotoxin composed of antibody ZME-018 and the plant toxin gelonin. Mol Biother 3:6
27. Scatchard G (1949) The attraction of proteins for small molecules and ions. Ann NY Acad Sci 51:660
28. Scheinberg DA, Houghton AN (1987) Current status of antitumor therapy with monoclonal antibodies. Oncology 1:31
29. Sivam G, Pearson JW, Bohn W, Oldham RK, Sadoff JC, Morgan AC Jr (1987) Immunotoxins to a human melanoma-associated antigen: comparison of gelonin with ricin and other A chain conjugates. Cancer Res 47:3169
30. Stirpe F, Olsnes S and Pihl A (1980) Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalinA. J Biol Chem 255:6947
31. Vaickus L, Foon KA (1991) Overview of monoclonal antibodies in the diagnosis and therapy of cancer. Cancer Invest 9:195
32. Vitetta ES (1988) The development of immunotoxins for the therapy of cancer, AIDS, and immune dysfunctions. International Symposium of the Princess Takamatsu Cancer Res Fund 19:333
33. Vitetta ES (1990) Immunotoxins: new therapeutic reagents for autoimmunity, cancer, and AIDS. J Clin Immunol 10:15S
34. Wargalla UC, Reisfeld RA (1989) Rate of internalization of an immunotoxin correlates with cytotoxic activity against human tumor cells. Proc Natl Acad Sci USA 86:5146
35. Wiley HS, Cunningham DD (1982) The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis. J Biol Chem 257:4222