Inhibitory activity of the equine infectious anemia virus major 5′ splice site in the absence of rev

Journal of Virology

Volumn 70, Issue 6, 1996, Pages 3645-3658

  Tan, Wei ^a   Schalling, Martin ^b   Zhao, Cuiping ^a   Luukkonen, Mattias ^a   Nilsson, Mia ^b   Fenyö, Eva Maria ^a   Pavlakis, George N ^c   Schwartz, Stefan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMPETITIVE INHIBITION; EQUINE INFECTIOUS ANEMIA VIRUS; GENE LOCATION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RNA SPLICING; SPLICEOSOME; STRUCTURAL GENE; TRANSCRIPTION REGULATION; VIRUS GENOME; VIRUS INHIBITION;

BASE SEQUENCE; GENE PRODUCTS, GAG; GENE PRODUCTS, REV; GENES, GAG; HELA CELLS; HUMANS; INFECTIOUS ANEMIA VIRUS, EQUINE; MOLECULAR SEQUENCE DATA; POINT MUTATION; RNA SPLICING; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0030011640     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (86)

1. Adachi, A., H. E. Gendelman, S. Koenig, T. Folks, R. Willey, A. Rabson, and M. A. Martin. 1986. Production of acquired immunodeficiency syndrome-associated retruvirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59:284-291.
2. Aebi, M., H. Hornig, R. A. Padgett, J. Reiser, and C. Weissraann. 1986. Sequence requirements for splicing of higher cukaryotic nuclear pre-mRNA. Tell 47:555-565.
3. Amendt, H. A., D. Hesslein, L.-J. Chang, and C. M. Stoltzfus. 1994. Presence of negative and positive ci-acting RNA splicing elements within and flanking the first et al coding exon of human immunodeficiency virus type 1. Mol. Cell. Biol. 14:3960-3970.
4. Amendt, B. A., Z.-H. Si, and C. M. Stoltzfus. 1995. Presence of exon splicing silencers within the human immunodeficiency virus type 1 tat exon 2 and tat-rev exon 3: evidence for inhibition mediated by cellular factors. Mol. Cell. Biol. 15:4606-4615.
5. Arrigo, S. J., and I. S. Y. Chen. 1991. Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs. Genes Dev. 5:808-819.
6. Beisel, C. E., J. F. Edwards, L. L. Dunn, and N. R. Rice. 1993. Analysis of multiple mRNAs from pathogenic equine infectious anemia virus (EIAV) in an acutely infected horse reveals a novel protein, Tim, derived from the carboxy terminus of the EIAV transmembrane protein. J. Virol. 67:832-842.
7. Black, A. C., I. S. Y. Chen, S. Arrigo, C. T. Ruland, T. Allogiamento, E. Chin, and J. D. Rosenblatt. 1991. Regulation of HTLV-II gene expression by Rex involves positive and negative cis-acting elements in the 5′ long terminal repeat. Virology 181:433-444.
8. Bogerd, H. P., R. A. Fridell, S. Madore, and B. R. Cullen. 1995. Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. Cell 82:485-494.
9. Bray, M., S. Prasad, J. W. Dubay, E. Hunter, K. T. Jeang, D. Rekosh, and M. L. Hammarskjöld. 1994. A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent. Proc. Natl. Acad. Sci. USA 91:1256-1260.
10. Brighty, D. W., and M. Rosenberg. 1994. A cis-acting repressive sequence that overlaps the Rev-responsive element of human immunodeficiency virus type 1 regulates nuclear retention of env mRNAs independently of known splice signals. Proc. Natl. Acad. Sci. USA 91:8314-8318.
11. Caputl, M., G. Casari, S. Giienzi, R. Tagliabue, A. Sidoli, C. A. Melo, and F. E. Baralle. 1994. A novel bipartite enhancer modulates the differential processing of the human fibronectin EDA exon. Nucleic Acids Res. 22:1018-1022.
12. Carroll, R., and D. Derse. 1993. Translation of equine infectious anemia virus bicistronic tat-rev mRNA requires leaky ribosome scanning of the tat CTG initiation codon. J. Virol. 67:1433-1440.
13. Carroli, R., L. Martarano, and D. Derse. 1991. Identification of lentivirus Tat functional domains through generation of equine infectious anemia virus/human immunodeficiency virus type 1 tat gene chimeras. J. Virol. 65:3460-3467.
14. Carvalho, M., and D. Derse. 1991. Mutational analysis of the equine infectious anemia virus Tat-responsive element. J. Virol. 65:3468-3474.
15. Chang, D. D., and P. A. Sharp. 1989. Regulation by HIV Rev depends upon recognition of splice sites. Cell 59:789-795.
16. Cheevers, W. P., and T. C. McGuire. 1985. Equine infectious anemia virus: immunopathogencsis and persistence. Rev. Infect. Dis. 7:83-88.
17. Cheevers, W. P., and T. C. McGuire. 1988. The lentiviruses: Maedi/visna, caprine arthritis-encephalitis, and equine infectious anemia. Adv. Virus Res. 34:189-215.
18. Cochrane, A. W., K. S. Jones, S. Beidas, P. J. Dillon, A. M. Skalka, and C. A. Rosen. 1991. Identification and characterization of intragenic sequences which repress human immunodeficiency virus structural gene expression. J. Virol. 65:5305-5313.
19. Cullen, B. R. 1992. Mechanism of action of regulatory proteins encoded by complex retroviruses. Microbiol. Rev. 56:375-394.
20. D'Agostino, D. M., B. K. Felber, J. E. Harrison, and G. N. Pavlakis. 1992. The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs. Mol. Cell. Biol. 12:1375-1386.
21. Derse, D., M. Carvalho, R. Carroll, and B. M. Peterlin. 1991. A minimal lentivirus Tat. J. Virol. 65:7012-7015.
22. Dorn, P., L. DaSilva, L. Martarano, and D. Derse. 1990. Equine infectious anemia virus tat: insights into the structure, function, and evolution of lentivirus trans-activator proteins. J. Virol. 64:1616-1624.
23. Dorn, P. L., and D. Derse. 1988. cis- and trans-acting regulation of gene expression of equine infectious anemia virus. J. Virol. 62:3522-3526.
24. Dunn, J. J., B. Krippl, K. E. Bernstein, H. Westphal, and F. W. Studier. 1988. Targeting bacteriophage T7 RNA polymerase to the mammalian cell nucleus. Gene 68:259-266.
25. Emerman, M., R. Vaieux, and K. Peden. 1989. The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization. Cell 57:1155-1165.
26. Eperon, I. C., D. C. Ireland, R. A. Smith, A. Maveda, and A. R. Krainer. 1993. Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF. EMBO J. 12:3607-3617.
27. Felber, B. K., M. Hadzopoulou-Cladaras, C. Cladaras, T. Copeland, and G. N. Pavlakis. 1989. Rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA. Proc. Natl. Acad. Sci. USA 86:1495-1499.
28. Fischer, U., J. Huber, W. C. Boelens, I. W. Mattaj, and R. Lührmann. 1995. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82:475-483.
29. Fischer, U., S. Meyer, M. Teufel, C. Heckel, R. Lührman, and G. Rautmann. 1994. Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA. EMBO J. 13:4105-4111
30. Franchini, G., K. A. Fargnoli, F. Giombini, L. Jagodzinski, A. De Rossi, M. Bosch, G. Biberfeld, E. M. Fenyö, J. Albert, R. C. Gallo, and F. Wong-Staal. 1989. Molecular and biological characterization of a replication competent human immunodeficiency type 2 (HIV-2) proviral clone. Proc. Natl. Acad. Sci. USA 86:2433-2437.
31. Fritz, C. C., M. L. Zapp, and M. R. Green. 1995. A human nucleoporin-like protein that specifically interacts with HIV Rev. Nature (London) 376:530-533.
32. Fu, X.-D., R. A. Katz, A. M. Skalka, and T. Maniatis. 1991. The role of the branchpoint and 3′-exon sequences in the control of balanced splicing of avian retrovirus RNA. Genes Dev. 5:211-220.
33. Fuerst, T. R., E. G. Niles, F. W. Studier, and B. Moss. 1986. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes hacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83:8122-8126.
34. Graham, F. J., and A. J. Van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-450.
35. Hadzopoulou-Cladaras, M., B. K. Felber, C. Cladaras, A. Athanassopoulos, A. Tse, and G. N. Pavlakis. 1989. The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region. J. Virol. 63:1265-1274.
36. Hamiharskjöld, M. L., J. Heimer, B. Hammarskjold, I. Sangwan, L. Albert, and D. Rekosh. 1989. Regulation of human immunodeficiency virus emexpression by the rev gene product. J. Virol. 63:1959-1966.
37. Henderson, L. E., R. C. Sowder, G. W. Smythers, and S. Oroszlan. 1987. Chemical and immunological characterization of equine infectious anemia virus gag-encoded proteins. J. Virol. 61:1116-1124.
38. Hope, T., and R. J. Pomerantz. 1995. The human immunodeficiency virus type 1 Rev protein: a pivotal protein in the viral life cycle, p. 91-105. In I. S. Y. Chen, H. Koprowski, A. Srinivasan, and P. K. Vogt (ed.), Transacting functions of human retroviruses, vol. 193. Springer-Verlag, Berlin.
39. Horowitz, D. S., and A. R. Krainer. 1994. Mechanisms for selecting 5′ splice sites in mammalian pre-mRNA splicing. Trends Genet. 10:100-106.
40. Kandels-Lewis, S., and B. Seraphin. 1993. Role of U6 snRNA in 5′ splice site selection. Science 262:2035-2039.
41. Kjems, J., M. Brown, D. D. Chang, and P. A. Sharp. 1991. Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element. Proc. Natl. Acad. Sci. USA 88:683-687.
42. Kohtz, J. D., S. F. Jamison, C. L. Will, P. Zuo, R. Luhrmann, M. A. GarcioBlanco, and J. L. Manley. 1994. Protein-protein interactions and 5′ splicesite recognition in mammalian mRNA precursors. Nature (London) 368: 119-124.
43. Konforti, B. B., M. J. Koziolkiewicz, and M. M. Konarska. 1993. Disruption of base pairing between the 5′ splice site and the 5′ end of U1 snRNA is required for spliceosome assembly. Cell 75:863-873.
44. Lavigueur, H. L., H. L. Branche, A. R. Kornblihtt, and B. Chabot. 1993. A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes Dev. 7:2405-2417.
45. Lawrence, J., A. Cochrane, C. Johnson, A. Perkins, and C. Rosen. 1991. The HIV-1 Rev protein: a model system for coupled RNA transport and translation. New Biol. 3:1220-1232.
46. Lesser, C. F., and C. Gulbrie. 1993. Mutations in U6 snRNA that alter splice site specificity: implications for the active site. Science 262:1982-1988.
47. Lu, X., J. Heimer, D. Rekosh, and M.-L. Hammarskjold. 1990. U1 small nuclear RNA plays a direct role in the formation of a rev-regulated human immunodeficiency virus env mRNA that remains unspliced. Proc. Natl. Acad. Sci. USA 87:7598-7602.
48. Luukkonen, B. G. M., W. Tan, and S. Schwartz. 1995. Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distance. J. Virol. 69:4086-4094.
49. Maldarelli, F., M. A. Martin, and K. Strebel. 1991. Identification of posttranscriptionally active inhibitory sequences in human immunodeficiency virus type 1 RNA: novel level of gene regulation. J. Virol. 65:5732-5743.
50. Malim, M. H., and B. R. Cullen. 1993. Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes. Mol. Cell. Biol. 13:6180-6189.
51. Malim, M. H., J. Hauber, S. Le, J. V. Maizel, and B. R. Cullen. 1989. The HIV-1 rev transactivator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature (London) 338:254-257.
52. Martarano, L., R. Stephens, N. Rice, and D. Derse. 1994. Equine infectious anemia virus trans-regulatory protein Rev controls viral mRNA stability, accumulation, and alternative splicing. J. Virol. 68:3102-3111.
53. Mount, S. M. 1982. A catalogue of splice junction sequences. Nucleic Acids Res. 10:459-472.
54. Nasioulas, G., A. S. Zolotukhin, C. Tabernero, L. Solomin, C. P. Cunningham, G. N. Pavlakis, and B. K. Felber. 1994. Elements distinct from human immunodeficiency virus type 1 splice site are responsible for the Rev dependence of env mRNA. J. Virol. 68:2986-2993.
55. Newman, A. J., and C. Norman. 1992. U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites. Cell 68:743-754.
56. Noiman, S., A. Yaniv, T. Tsach, L. Sherman, T. Mild, S. R. Tronick, and A. Gazit. 1991. The tat protein of equine infectious anemia virus is encoded by at least three types of transcripts. Virology 184:521-530.
57. Pedersen, N. C. 1989. Animal virus infections that defy vaccination: equine infectious anemia, caprine arthritis-encephalitis, maedi-visna, and feline infectious peritonitis. Adv. Vet. Sci. Comp. Med. 33:413-428.
58. Reddy, R. 1985. Compilation of small RNA sequences. Nucleic Acids Res. 13:155-163.
59. Rimsky, L., J. Hauber, M. Dukovich, M. H. Malim, A. Langlois, B. R. Cullen, andW. C. Greene. 1988. Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein. Nature (London) 335:738-740.
60. Rosen, C. A., E. Terwilliger, A. Dayton, J. G. Sodroski, and W. A. Haseltine. 1988. Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 85:2071-2075.
61. Rosin-Arbesfeld, R., M. Rivlin, S. Noiman, P. Mashiah, A. Yaniv, T. Miki, S. R. Tronick, and A. Gazit. 1993. Structural and functional characterization of rev-like transcripts of equine infectious anemia virus. J. Virol. 67:5640-5646.
62. Schalling, M., K. Friberg, K. Seroogy, P. Riederer, E. Bird, S. N. Schiffmann, P. Mailleux, J.-J. Vanderhaeghen, S. Kuga, M. Goldstein, K. Kitahama, P. H. Luppi, M. Jouvet, and T. Hökfelt. 1990. Analysis of expression of cholecystokinin in dopamine cells in the ventral mesencephalon of several species and in humans with schizophrenia. Proc. Natl. Acad. Sci. USA 87:8427-8431.
63. Schwartz, S., M. Campbell, G. Nasioulas, J. Harrison, B. K. Felber, and G. N. Pavlakis. 1992. Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expression. J. Virol. 66:7176-7182.
64. Schwartz, S., B. K. Felber, D. M. Benko, E. M. Fenyö, and G. N. Pavlakis. 1990. Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type J. J. Virol. 64:2519-2529.
65. Schwartz, S., B. K. Felber, and G. N. Pavlakis. 1992. Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein. J. Virol. 66:150-159.
66. Seiki, M., A. Hikikoshi, and M. Yoshida. 1990. The US sequence is a cisacting repressive element for genomic RNA expression of human T cell leukemia virus type 1. Virology 176:81-86.
67. Sherman, L., A. Gazit, A. Yaniv, T. Kawakami, J. E. Dahlberg, and S. R. Tronick. 1988. Localization of sequences responsible for trans-activation of the equine infectious anemia virus long terminal repeat. J. Virol. 62:120-126.
68. Sherman, L., A. Yaniv, H. Lichtman-Pleban, S. R. Tronick, and A. Gazit. 1989. Analysis of regulatory elements of the equine infectious anemia virus and caprine arthritis-encephalitis virus long terminal repeats. J. Virol. 63: 4925-4931.
69. Sontheimer, E. J., and J. A. Steitz. 1993. The U5 and U6 small nuclear RNAs as active site components of the spliceosome. Science 262:1989-1996.
70. Staffa, A., and A. Cochrane. 1995. Identification of positive and negative splicing regulatory elements within the terminal tat-rev exon of human immunodeficiency virus type l. Mol. Cell. Biol. 15:4597-4605.
71. Staffa, A., and A. Cochrane. 1994. The tat/rev intron of human immunodeficiency virus type 1 is inefficiently spliced because of suboptimal signals in the 3 ′splice site. J. Virol. 68:3071-3079.
72. Staknis, D., and R. Reed. 1994. SR proteins promote the first specific recognition of pre-mRNA and are together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex. Mol. Cell. Biol. 11:7670-7682.
73. Stephens, R. M., J. W. Casey, and N. R. Rice. 1986. Equine infectious anemia virus gag and pol genes: relatedness to visna and AIDS virus. Science 231: 589-594.
74. Stephens, R. M., D. Derse, and N. R. Rice. 1990. Cloning and characterization of cDNAs encoding equine infectious anemia virus Tat and putative Rev proteins. J. Virol. 64:3716-3725.
75. Stripecke, R., and M. W. Hentze. 1992. Bacteriophage and spliceosomal proteins function as position-dependent cis/trans repressers of mRNA translation in vitro. Nucleic Acids Res. 20:5555-5564.
76. Tan, W., B. K. Felber, A. S. Zolotukhin, G. N. Pavlakis, and S. Schwartz. 1995. Efficient expression of the human papillomavirus type 16 L1 protein in epithelial cells by using Rev and the Rev responsive element of human immunodeficiency virus or the cis-acting transactivation element of simian retrovirus type 1. J. Virol. 69:5607-5620.
77. Tan, W., and S. Schwartz. 1995. The Rev protein of human immunodeficiency virus type 1 counteracts the effect of an AU-rich negative element in the human papillomavirus type 1 late 3′ untranslated region. J. Virol. 69: 2932-2945.
78. Tanaka, K., A. Watakabe, and Y. Shiraura. 1994. Polypurine sequences within a downstream exon function as a splicing enhancer. Mol. Cell. Biol. 14:1347-1354.
79. Temin, H. M. 1993. A proposal for a new approach to a preventive vaccine against human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 90:4419-4420.
80. Unge, D., L. Solomin, M. Mellini, D. Derse, B. K. Felber, and G. N. Pavlakis. 1991. The Rex regulatory protein of human T-cell lymphotropic virus type I binds specifically to its target within the viral RNA. Proc. Natl. Acad. Sci. USA 88:7145-7149.
81. Watakabe, A., K. Tanaku, and Y. Shimura. 1993. The role of exon sequences in splice site selection. Genes Dev. 7:407-418.
82. Xu, R., J. Teng, and T. A. Cooper. 1993. The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol. Cell. Biol. 13:3660-3674.
83. Zhuang, Y., H. Leung, and A. M. Weiner. 1987. The natural 5′ splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA. Mol. Cell. Biol. 7:3018-3020.
84. Zhuang, Y., and A. M. Weiner. 1986. A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation. Cell 46:827-835.
85. Zolotukhin, A. S., A. Valentin, G. N. Pavlakis, and B. K. Felber. 1994. Continuous propagation of RRE(-) and Rev(-)RRE(-) human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes J Virol 68:7944-7952.
86. Zuo, P., and J. L. Manley. 1994. The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5′splice sites. Proc. Natl. Acad. Sci. USA 91:3363-3367.