Clinical assessment of modafinil

Drugs of Today

Volumn 32, Issue 4, 1996, Pages 339-347

  Laffont, F ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL STIMULANT AGENT; MODAFINIL;

AGE; AGED; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ELECTROENCEPHALOGRAM; HUMAN; HUMAN EXPERIMENT; INSOMNIA; NARCOLEPSY; NORMAL HUMAN; REVIEW;

EID: 0030011530     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: None     Document Type: Review

References (27)

1. Sebban, CI. Double-blind placebo-controlled study of the effects of CRL 40476 as a single oral dose of 200 mg in young healthy volunteers. Clinical expert report, Laboratoire Lafon, 1985.
2. Saletu, B., Frey, R., Krupka, M. Anderer, P., Grünberger, J. Differential effects of a new central adrenergic agonist modafinil and D-amphetamine on sleep and early morning behaviour in young healthy volunteers. Int J Clin Pharm Res 1989, 9 (3): 183-95.
3. Goldenerg, G F. Administration of a morning or evening dose of 200 mg of modafinil. Comparison of the effects on night sleep and daytime alertness in comparison with a placebo). Clinical expert report E725, Laboratoire Lafon, 1983.
4. Goldenberg, F., Weil, J.S., Von Frenckeel, R. Effects of modafinil on diurnal variation of objective sleepiness in normal subjects. 5th Int Cong Sleep Res (June 28-July 3, Copenhagen) 1987, 149.
5. Goldenberg, F. Mise au point d'un indice EEG de la vigilance diurne. Applications aux essais pharmacologiques. Rev EEG Neurophysiol 1986, 16: 39-48.
6. Goldenberg, F. Study of the effects of 200 mg of modafinil on performances, daytime alertness and nighttime sleep in comparison with a placebo. Clinical expert report, Laboratoire Lafon, 1985.
7. Benoit, O., Clodore, M., Touron, N., Pailhous, E. Effects of modafinil on sleepiness in normal sleep deprived and symptomatic subjects. 5th Int Cong Sleep Res (June 28-July 3, Copenhagen) 1987, 135.
8. Richet, F. Action of modafinil on neuro-sensorial alertness in sleep deprived automobile drivers. Clinical expert report E801, Laboratoire Lafon, 1984.
9. Lagarde, D., Batejat, D., Anton, G., Pradella, S. Aide pharmacologique dans une situation d'éveil prolongé. Etude du modafinil. Journée Thématique DRET. Efficience mentale et rythmes biologiques. Arcueil 1991.
10. Simon, P., Puech, A., Bensimon, ?, Warot, D. Effects of modafinil on psychomotor and memory performances in healthy subjects. Study of antagonism of triazolam-induced sedation and amnesia with 3 doses of modafinil. Clinical expert report E841, Laboratoire Lafon, 1986.
11. Saletu, B., Grünberger, J., Linzmayer, L., Storh, H. Pharmaco-EEG, psychometric and plasma level studies with two α-adrenergic stimulants CRL 40-476 and adrafinil in elderlies. New Trends Exp Clin Psychiatr 1986, 2 (1): 5-31.
12. Obrist, W.D. EEG changes in normal aging and dementia, in: Brain Function in Old Age. Hoffmeistern, F., Müller, C. (Eds.). Springer-Verlag: Berlin/New York 1979, 102-11.
13. Saletu, B., Frey, R., Krupka, M., Anderer, P., Grünberger, J., Barbanoj, M. Differential effects of the new central adrenergic agonist modafinil and D-amphetamine on sleep and early morning behaviour in elderlies. Arzneim-Forsch/Drug Res 1989, 39 (10): 1268-73.
14. Warot, D., Corruble, E., Payan, C., Weil, J.S. Subjective effects of modafinil, a new central adrenergic stimulant, in healthy volunteers. A comparison with amphetamine, caffeine and placebo. Eur Psychiatr 1993, 8: 201-8.
15. Bastuji, H., Jouvet, M. Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil. Prog Neuro-Psychopharmacol Biol Psychiat 1988, 12: 695-700.
16. Billard, M. New treatment for narcolepsy. Congress of National Institute of Health Workshop of Narcolepsy. Bethesda, MD, 1990.
17. Laffont, F., Mayer, G., Minz, M. Modafinil in diurnal sleepiness. A study of 123 patients. Sleep 1994, 17: S113-5.
18. Laffont, F., Cathala, H.P., Waisbord, P., Kohler, F. Effects of modafinil on narcoleptic patients. Double blind cross over study. 9th Eur Cong Sleep Res (Sept 4-9, Jerusalem) 1988, 21.
19. Billiard, M., Besset, A., Montplaisir, J. et al. Modafinil: A double blind multicentric study. Sleep 1994, 17: 5107-12.
20. Marchand, F., Cuartas, J., Bonora, I., Garma, L., Galland, Y., Lubin, S. Résultats thérapeutiques du modafinil chez 32 patients sur 112 hypersomniaques examinés a l'unité de sommeil. Neurophysiol Clin 1991, 21: 213-36.
21. Laffont, F. Spectral analysis of wakefulness and sleepiness in narcoleptic patients. Effect of modafinil. J Sleep Res 1992, Suppl. 1.
22. Laffont, F., Agar, N., Mayer, G., Minz, M. Effet du modafinil chez des patients narcoleptiques. Etudes électrophysiologique et psychométrique. Neurophysiol Clin 1995, 25: 84-95.
23. Besset, A., Tafti, M., Villemin, E., Billard, M. Effet du modafinil (300 mg) sur le sommeil, la somnolence et la vigilance du narcoleptique. Neurophysiol Clin 1993, 23: 47-60.
24. Boivin, D.B., Montplaisir, J., Petit, D., Lambert, C., Lubin, S. Effects of modafinil on symptomatology of human narcolepsy. Clinical Neuropharmacol 1993, 16 (1): 46-53.
25. Garma, L., Gallard, Y., Levy, F., Marchand, F. Le renforcement et l'éveil comme traitement de l'insomnie et de la narcolepsie. Effet du CRL 40-476. Encéphale 1986, 12: 177.
26. Saletu, B., Saletu, M., Grünberger, J., Frey, R., Anderer, P., Mader, R. Treatment of the alcoholic organic brain syndrome: Double-blind, placebo-controlled trial. Clinical, psychometric and electroencephalographic mapping studies with modafinil. Neuropsychobiology 1993, 27: 26-39.
27. Digonnet, C., Boyer, P., Puech, A., Frenckell, R.V., Weil, J.S. Les échelles AMDP dans l'é volution des psychotropes en phase II. Acta Psychiat BeIg 1987, 87: 245-52.