Bone targeted drugs 2. Synthesis of estrogens with hydroxyapatite affinity

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 9, 1996, Pages 1047-1050

  Willson, Timothy M ^a   Henke, Brad R ^a   Momtahen, Tanya M ^a   Garrison, Deanna T ^a   Moore, Linda B ^a   Geddie, Nora G ^a   Baer, Philip G ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 4 PYRAZOLECARBOXYLIC ACID; ALKALINE PHOSPHATASE; ESTROGEN; ESTROGEN RECEPTOR; HEXESTROL; HYDROXYAPATITE; PYRAZOLE DERIVATIVE; TETRACYCLINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BONE; CALCIUM BINDING; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INDUCTION; MOUSE; NONHUMAN; RAT;

EID: 0030011437     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00165-5     Document Type: Article

References (10)

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4. Willson, T. M.; Charifson, P. S.; Baxter, A. D.; Geddie, N. G. Preceding paper in this journal.
5. 4 requires: C, 60.9; H, 5.8; N, 10.1
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7. Landvatter, S. W.; Katzenellenbogen, J. A. J. Med. Chem. 1982, 24, 1300.
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9. Willson, T. M.; Henke, B. R.; Momtahen, T. M.; Charifson, P. S.; Batchelor, K. W.; Lubahn, D. B.; Moore, L. B.; Oliver, B. B.; Sauls, H. R.; Triantafillou, J. A.; Wolfe, S. G.; Baer, P. G. J. Med. Chem. 1994, 37, 1550.
10. The control compound 3 was synthesized from reaction of the mesylate of alcohol 8 and the sodium salt of ethyl 4-pyrazole carboxylate, followed by the standard deprotection and purification as the dicyclohexylamine salt. Figure Presented