Early ultrastructural changes of human keratinocytes after HIV-1 contact: An in vitro study

European Journal of Dermatology

Volumn 6, Issue 3, 1996, Pages 213-218

  Cenacchi, Giovanna ^a   Guiducci, Germana ^a   Pasquinelli, Gianandrea ^a   Re, Maria C ^a   Ramazzotti, Eric ^a   Furlini, Giuliano ^a   Malorni, Walter ^b   De Luca, Michele ^c   Martinelli, Giuseppe N ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

Cytoskeleton; Electron microscopy; HIV 1; Human epidermal keratinocyte; Skin pathology

Indexed keywords

GLYCOPROTEIN GP 120;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; KERATINOCYTE; MOLECULAR BIOLOGY; NORMAL HUMAN; SCANNING ELECTRON MICROSCOPY; ULTRASTRUCTURE; VIRUS INFECTION;

EID: 0030011017     PISSN: 11671122     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Kaplan MH, Sadick NS, McNutt NS, Meltzer M, Sarngadharan G, Pahwa S. Dermatologic findings and manifestations of acquired immunodeficiency syndrome (AIDS). J Am Acad Dermatol 1987; 16: 485-506.
2. Vogel J, Hinrichs SH, Reynolds RK, Luciw PA, Jay G. The HIV Tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice. Nature 1988; 335: 606-11.
3. McNutt NS, Urmacher C. Las erupciones papuloesacamosas del sindrome de immunodeficiencia adquirida (SIDA). Patologia 1990; 23: 3-9.
4. McNutt NS. Skin diseases associated with human lymphotropic retrovirus infection. Proc 19th Congr Int Acad Pathol, Madrid, 1992; 97-9.
5. Orenstein JM. Ultrastructural pathology of human immunodeficiency virus infection. Ultrastruct Pathol 1992; 16: 179-210.
6. Cao Y, Friedman-Kien AE, Huang Y, Li XL, Mirabile M, Moudgil T, Zucker-Franklin D, Ho DD. CD4-independent, productive human immunodeficiency virus type 1 infection of hepatoma cell lines in vitro. J Virol 1990; 64: 2553-9.
7. Owens RJ, Dubay JW, Hunter E, Compans W. Human immunodeficiency virus envelope protein determines the site of virus release in polarized epithelial cells. Proc Natl Acad Sci USA 1991; 88: 3987-91.
8. Douglas GC, Fry GN, Thirkill T, Holmes E, Hakim H, Jennings M, King BF. Cell-mediated infection of human placental trophoblast with HIV in vitro. AIDS Res Hum Retrov 1992; 9: 735-9.
9. Phillips DM, Bourinbaiar AS. Mechanism of HIV spread from lymphocytes to epithelia. Virology 1992; 186: 261-73.
10. Phillips MD, Zacharopulous VR, Tan X, Pearce-Pratt R. Mechanisms of sexual transmission of HIV: does HIV infect intact epithelia? Trends Microbiol 1994; 2: 454-8.
11. Zacharopoulos VR, Perotti ME, Phillips DM. Lymphocyte- facilitated infection of epithelia by human T-cell lymphotropic virus type I. J Virol 1992; 66: 4601-5.
12. Levy JA. Pathogenesis of human immunodeficiency virus infection. Microbiol Rew 1993; 57: 183-289.
13. Stingl G, Rappersberger K, Tschachler E, Gartner S, Groh V, Mann DL, Wolff K, Popovic M. Langerhans cells in HIV-1 infection. J Am Acad Dermatol 1990; 22: 1210-7.
14. Zambruno G, Mori L, Marconi A. Detection of HIV-1 in epidermal Langerhans cells of HIV-infected patients using the polymerase chain reaction. J Invest Dermatol 1991; 96: 979-82.
15. Ramazzotti E, Marconi M, Re MC, Gicolomoni G, Cenacchi G, Vignoli M, Zambruno G, Furlini G, La Placa M, Giannetti A. In vitro infection or human Langerhans cells with HIV-1. Immunol 1995; 85: 94-8.
16. De Luca M, Franzi AT, D'Anna F, Zicca A, Albanese E, Bondanza S, Cancedda R. Co-culture of human keratinocytes ond melanocytes: differentiated melanocytes are physiologically organized in the basal layer of the culture epithelium. Eur J Cell Biol 1988; 46: 176-80.
17. Popovic M, Sarngadharan MG, Read E, Gallo RC. Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 1984; 224: 497-500.
18. Lee MH, Sano K, Morales FE, Imagawa DT. Comparable sensitivities for detection of human immunodeficiency virus by sensitive reverse transcriptase and antigen capture enzyme-linked immunosorbent assays. J Clin Microbiol 1988; 26: 371-4.
19. Sodroski J, Goh WC, Rosen C. Replicative and cytopathic potential of HTLV III/LAV with sor gene delections. Science 1986; 231: 1549-53.
20. Nottet H, Janse I, de Graff L, Bakker L, Visser MR, Verhoef J. Infection of epithelial cell line Hep-2 with human immunodeficiency virus type 1 is CD4 dependent. J Med Virol 1993; 40: 39-43.
21. Toniolo A, Serra C, Conaldi PG, Basolo F, Falcone V, Dolei A. Productive HIV-1 infection of normal human epithelial cells. AIDS 1995, 9: 859-65.
22. Malorni W, Donelli G. Cell death. General features and morphological aspects. Aging Cell Def Mech 1992; 663: 218-33.
23. Voss TG, Fernier CD, Garry RF. Alterations of ion transport by HIV. Abstr Book Int Conf AIDS, Berlin, 1993: 180.
24. Lufting RB, Lupo LD. Viral interactions with the host-cell cytoskeleton: the role of retroviral proteases. Trends Microbiol 1994; 2: 178-82.
25. Honer J, Shoeman RL, Traub P. Human immunodeficiency virus type 1 protease microinjected into cultured human skin fibroblasts cleaves vimentin and affects cytoskeletal and nuclear architecture. J Cell Sci 1991; 100: 799-807.
26. Shoeman RL, Honer J, Stoller TJ, Kesselmeier C, Miedel MC, Traub P, Graves MC. Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein. Proc Natl Acad Sci USA 1990; 87: 6336-40.
27. Levi G, Patrizio M, Bernardo A, Petrucci TC. Human immunodeficiency virus coat protein gp120 inhibits the beta- adrenergic regulation of astroglial and microglial functions. Proc Natl Acad Sci USA 1993; 90: 1541-5.