Further studies on the buffer-catalyzed cleavage and isomerization of uridyluridine. Medium and ionic strength effects on catalysis by morpholine, imidazole, and acetate buffers help clarify the mechanisms involved and their relationship to the mechanism used by the enzyme ribonuclease and by a ribonuclease mimic

Journal of the American Chemical Society

Volumn 118, Issue 28, 1996, Pages 6588-6600

  Breslow, Ronald ^a   Dong, Steven D ^a   Webb, Yael ^a   Xu, Ruo ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMIDAZOLE; MORPHOLINE; RIBONUCLEASE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE; URIDYLURIDINE;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; IONIC STRENGTH; REACTION ANALYSIS;

EID: 0030010889     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9526933     Document Type: Article

References (37)

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10. Much ado has been made about our use of the phrase "negative catalysis". This term was first used by L. P. Hammett (Physical Organic Chemistry, 1st ed.; McGraw-Hill Book Company: New York, 1940: p 398). It simply means that a species that is functioning as a catalyst (i.e., it is not changed at the end of the reaction, and it is not simply an inhibitor of another catalyst) is observed to slow a reaction. Of course it does it by speeding another reaction in a branching process. I do not retract the use of this perfectly apt phrase by us or by Hammett.
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13. First suggested by Charles Perrin as an anonymous referee of ref 12.
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