Genes responsible for nisin synthesis, regulation and immunity form a regulon of two operons and are induced by nisin in Lactoccocus lactis N8

Microbiology

Volumn 142, Issue 5, 1996, Pages 1281-1288

  Ra, S Runar ^a   Qiao, Mingqiang ^a   Immonen, Tiina ^a   Pujana, Idoia ^a   Saris, Per E J ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Lactococcus lactis; Nisin regulon; Signal transduction; Transcriptional regulation

Indexed keywords

NISIN; POLYPEPTIDE ANTIBIOTIC AGENT;

ANTIMICROBIAL ACTIVITY; ARTICLE; AUTOREGULATION; BACTERIAL GROWTH; CELL SURFACE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG SYNTHESIS; GENE CLUSTER; GENE MAPPING; GENETIC TRANSCRIPTION; IMMUNITY; LACTOCOCCUS LACTIS; NONHUMAN; NORTHERN BLOTTING; OPERON; PH; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; REGULON; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); LACTOCOCCUS LACTIS; STREPTOCOCCUS;

EID: 0030010883     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/13500872-142-5-1281     Document Type: Article

References (34)

1. Albright, L. M., Huala, E. & Ausubel, F. M. (1989). Prokaryotic signal transduction mediated by sensor and regulator protein pairs. Annu Rev Genet 23, 311-336.
2. Axelsson, L. T., Ahrne, S. E. J., Andersson, M. C. & Ståhl, S. R. (1988). Identification and cloning of a plasmid-encoded erythromycin resistance determinant from Lactobacillus reuteri. Plasmid 20, 171-174.
3. Banerjee, S. & Hansen, J. N. (1988). Structure and expression of a gene encoding the precursor of subtilin, a small protein antibiotic. J Biol Chem 263, 9508-9514.
4. Buchman, G. W., Banerjee, S. & Hansen, J. N. (1988). Structure, expression, and evolution of a gene encoding the precursor of nisin, a small protein antibiotic. J Biol Chem 263, 16260-16266.
5. Carter, M. & Milton, I. D. (1993). An inexpensive and simple method for DNA purifications on silica particles. Nucleic Acids Res 21, 1044.
6. Delves-Broughton, J. (1990). Nisin and its application as a food preservative. J Society Dairy Technol 43, 73-76.
7. Dodd, H. M. & Gasson, M. J. (1994). Bacteriocins of lactic acid bacteria. In Genetics and Biotechnology of Lactic Acid Bacteria, pp. 211-251. Edited by M. J. Gasson & W. M. de Vos. Glasgow: Blackie.
8. Dodd, H. M., Horn, N. & Gasson, M. J. (1990). Analysis of the genetic determinant for production of the peptide antibiotic nisin. J Gen Microbiol 136, 555-566.
9. Engelke, G., Gutowski-Eckel, Z., Hammelmann, M. & Entian, K.-D. (1992). Biosynthesis of the lantibiotic nisin: genomic organisation and membrane localisation of the NisB protein. Appl Environ Microbiol 58, 3730-3743.
10. Engelke, G., Gutowski-Eckel, Z., Kiesau, P., Siegers, K. , Hammelmann, M. & Entian, K.-D. (1994). Regulation of nisin biosynthesis and immunity in Lactococcus lactis 6F3. Appl Environ Microbiol 60, 814-825.
11. Gao, F., Abee, T. & Konings, W. N. (1991). Mechanism of action of the peptide antibiotic nisin in liposomes and cytochrome c oxidase containing proteoliposomes. Appl Environ Microbiol 57, 2164-2170.
12. Gasson, M. J. (1983). Plasmid complements of Streptococcus lactis NCDO712 and other lactic streptococci after protoplast induced curing. J Bacteriol 154, 1-9.
13. Graeffe, T., Rintala, H., Paulin, L. & Saris, P. (1991). A natural nisin variant. In Nisin and Novel Lantibiotics, pp. 260-268. Edited by G. Jung & H.-G. Sahl. Leiden: ESCOM Science Publishers.
14. Hanahan, D. (1983). Studies on transformation of Escherichia coli with plasmids. J Mol Biol 16, 557-580.
15. Hurst, A. & Peterson, G. M. (1971). Observations on the conversion of an inactive precursor protein to the antibiotic nisin. Can J Microbiol 17, 1379-1384.
16. Immonen, T., Ye, S., Ra, R., Qiao, M., Paulin, L. & Saris, P. E. J. (1995). The codon usage of the nisZ operon in Lactococcus lactis N8 suggests a non-lactococcal origin of the conjugative nisin-sucrose transposon. DNA Sequence 5, 203-218.
17. King, T. C. & Schlessinger, D. (1987). Processing of RNA transcripts. In Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology, pp. 703-718. Edited by F. C. Neidhart and others. Washington, DC: American Society for Microbiology.
18. Kuipers, O. P., Beerthuyzen, M. M., Siezen, R. J. & de Vos, W. (1993). Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of nisin immunity. Eur J Biochem 216, 281-291.
19. Liu, W. & Hansen, J. N. (1990). Some chemical and physical properties of nisin, a small-protein antibiotic produced by Lactococcus lactis. Appl Environ Microbiol 56, 2551-2558.
20. Maniatis, J., Fritsch, E. F. & Sambrook, J. (1982). Molecular Cloning: a Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbour Laboratory.
21. van der Meer, J. R., Polman, J., Beerthuyzen, M. M., Siezen, R. J., Kuipers, O. P. & de Vos, W. (1993). Characterization of the Lactococcus lactis nisin A operon genes nisP, encoding a subtilisin-like serine protease involved in precursor processing, and nisR, encoding a regulatory protein involved in nisin biosynthesis. J Bacteriol 174, 2152-2159.
22. Myöhänen, S. & Wahlfors, J. (1993). Automated fluorescent primer extension. Biotechniques 14, 16-17.
23. Mulders, J. W. M., Boerrighter, I. J., Rollema, H. S., Siezen, R. J. & de Vos, W. (1991). Identification and characterization of the lantibiotic nisin Z, a natural nisin variant. Eur J Biochem 201, 581-584.
24. Qiao, M., Immonen, T., Koponen, O. & Saris, P. E. J. (1995). The cellular location and effect on nisin immunity of the NisI protein from Lactococcus lactis N8 expressed in Escherichia coli and L. lactis. FEMS Microbiol Lett 131, 75-80.
25. Ra, S. R. & Saris, P. E. J. (1995). Characterization of procaryotic mRNAs by RT-PCR. Biotechniques 18, 792-795.
26. Schnell, N., Entian, K.-D., Schneider, U., Götz, F., Zahner, H., Kellner, R. & Jung, G. (1988). Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulfide-rings. Nature 333, 276-278.
27. Sibakov, M., Koivula, T., von Wright, A. & Palva, I. (1991). Secretion of TEM β-lactamase with signal sequences isolated from the chromosome of Lactococcus lactis subsp. lactis. Appl Environ Microbiol 57, 341-348.
28. Siegers, K. & Entian, K.-D. (1995). Genes involved in immunity to the lantibiotic nisin produced by Lactococcus lactis 6F3. Appl Environ Microbiol 61, 1081-1089.
29. Steen, M. T., Chung, Y. J. & Hansen, J. N. (1991). Characterization of the nisin gene as a part of a polycistronic operon in the chromosome of Lactococcus lactis ATCC 11454. Appl Environ Microbiol 57, 1181-1188.
30. Terzaghi, B. E. & Sandine, W. E. (1975). Improved medium for lactic streptococci and their bacteriophages. Appl Microbiol 29, 807-813.
31. de Vos, W. M. & Simmons, G. F. M. (1994). Gene cloning and expression systems in lactococci. In Genetics and Biotechnology of Lactic Acid Bacteria, pp. 52-97. Edited by M. J. Gasson & W. M. de Vos. Glasgow: Blackie.
32. de Vuyst, L. & Vandamme, E. J. (1992). Influence of the carbon source on nisin production in Lactococcus lactis subsp. lactis batch fermentations. J Gen Microbiol 138, 571-578
33. de Vuyst, L. & Vandamme, E. J. (1993). Influence of the phosphorus and nitrogen source on nisin production in Lactococcus lactis subsp. lactis batch fermentations using a complex medium. Appl Microbiol Biotechnol 40, 17-22.
34. Yang, R., Johnson, M. C. & Ray, B. (1992). A novel method to extract large amounts of bacteriocins from lactic acid bacteria. Appl Environ Microbiol 58, 3355-3359.