p53 accumulates in micronuclei after treatment with a DNA breaking chemical, methylnitrosourea, and with the spindle poison, vinblastine

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 352, Issue 1-2, 1996, Pages 61-64

  Granetto, C ^a   Ottaggio, L ^a   Abbondandolo, A ^a,b   Bonatti, S ^a,c  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c IMD   (Italy)

Author keywords

Micronuclei; N methyl N nitrosourea; p53; Vinblastine

Indexed keywords

METHYLNITROSOUREA; MONOCLONAL ANTIBODY; PROTEIN P53; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL AGING; CELL CULTURE; CHO CELL; DNA DEGRADATION; DNA STRAND BREAKAGE; IMMUNOCYTOCHEMISTRY; MAMMAL CELL; MICRONUCLEUS; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TUMOR SUPPRESSOR GENE;

ANIMALIA; MAMMALIA;

EID: 0030010662     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(95)00235-9     Document Type: Article

References (8)

1. Bonatti, S., Z. Cavalieri, S. Viaggi and A. Abbondandolo (1992) The analysis of 10 potential spindle poisons for their ability to induce CREST-positive micronuclei in human diploid fibroblasts, Mutagenesis, 7, 111-114.
2. 1 arrest and long-term induction of Cip1 in normal human fibroblasts, Genes Dev., 8, 2540-2551.
3. Evans, H.J. (1976) Cytological methods for detecting chemical mutagens, in: A. Hollander (Ed.), Chemical Mutagens, Plenum Publ. Co., New York, pp. 1-29.
4. Fritsche, M., C. Haessler and G. Brandner (1993) Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents, Oncogene, 8, 307-318.
5. Lu, X. and D.P. Lane (1993) Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell, 75, 765-778.
6. Nelson, W.G. and M.B. Kastan (1994) DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA response pathways, Molec. Cell. Biol., 14, 1815-1823.
7. Oberosler, P., P. Hloch, U. Ramsperger and H. Stahl (1993) p53 catalized annealing of complementary single-stranded nucleic acid, EMBO J., 12, 2389-2396.
8. Unger C., S. Kress, A. Buchmann and M. Schwarz (1994) γ-irradiation-induced micronuclei from mouse hepatoma cells accumulate high levels of the tumor suppressor protein p53, Cancer Res., 54, 3651-3655.