Utility of pancreatic digestive enzyme immunohistochemistry in the differential diagnosis of hepatocellular carcinoma, cholangiocarcinoma and metastatic adenocarcinoma of the liver

Pathology International

Volumn 46, Issue 3, 1996, Pages 183-188

  Terada, Tadashi ^a   Nakanuma, Yasuni ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

cholangiocarcinoma; hepatocellular carcinoma; metastatic adenocarcinoma; pancreatic digestive enzyme immunohistochemistry

Indexed keywords

CHYMOTRYPSINOGEN; TRIACYLGLYCEROL LIPASE; TRYPSINOGEN;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER DIAGNOSIS; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER METASTASIS; MALE; PRIORITY JOURNAL;

EID: 0030010646     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1827.1996.tb03596.x     Document Type: Article

References (28)

1. Allen RA, Lisa RJ. Combined liver cell and bile duct carcinoma. Am. J. Pathol. 1949; 25: 647-655.
2. Fischer HP, Altmannsberger M, Werber K, Osborne M. Keratin polypeptides in malignant epithelial liver tumors. Am. J. Pathol. 1987; 127: 530-537.
3. Johnson DE, Herndier BG, Medeiros LJ, Warnke RA, Rouse RV. The diagnostic utility of the keratin profiles of hepatocellular carcinoma and cholangiocarcinoma. Am. J. Surg. Pathol. 1988; 12: 187-197.
4. Lai YS, Thung SN, Gerber MA, Chen ML, Schaffner F. Expression of cytokeratins in normal and diseased livers and in primary liver carcinomas. Arch. Pathol. Lab. Med. 1989; 113: 34-38.
5. Van Eyken P, Sciot R, Paterson A, Callea F, Kew MC, Desmet VJ. Cytokeratin expression in hepatocellular carcinoma: An immunohistochemical study. Hum. Pathol. 1988; 19: 562-569.
6. Balaton AJ, Nehama-Sibony M, Gotheil C, Callard P, Bavierra EE. Distinction between hepatocellular carcinoma, cholangiocarcinoma and metastatic carcinoma based on immunohistochemical staining for carcinoembryonic antigen and for cytokeratin 19 on paraffin sections. J. Pathol. 1988; 156: 305-310.
7. Hurlimann J, Cardiol D. Immunohistochemistry in the differential diagnosis of liver carcinomas. Am. J. Surg. Pathol. 1991; 15: 280-288.
8. Lee FY, Lee SD, Tsai YT, Wu JC, Lai KH, Lo KJ. Serum C-reactive protein as a serum marker for the diagnosis of hepatocellular carcinoma. Cancer 1989; 63: 1567-1571.
9. Ganjei P, Nadji M, Albores-Saavedra J, Morales AR. Histologic markers in primary and metastatic tumors of the liver. Cancer 1988; 62: 1994-1998.
10. Jovanovic R, Jagirdar J, Thung SN, Paronetto F. Blood-group-related antigens Lewis x and Lewis y in the differential diagnosis of cholangiocarcinoma and hepatocellular carcinoma. Arch. Pathol. Lab. Med. 1989; 113: 139-142.
11. Brumm C, Schulze C, Charels K, Motohashi T, Kloppel G. The significance of alpha-fetoprotein and other tumor markers in differential immunohistochemistry of primary liver tumors. Histopathology 1989; 14: 503-513.
12. Goodman ZD, Ishak KG, Langloss JM, Sesterhenn IA, Rabin L. Combined hepatocellular cholangiocellular carcinoma: A histologic and immunohistochemical study. Cancer 1985; 55: 124-135.
13. Imoto M, Nishimura D, Fukuda Y, Sugiyama K, Kumada T, Nakano S. Immunohistochemical detection of alpha-fetoprotein, carcinoembryonic antigen, and ferritin in formalin-paraffin sections from hepatocellular carcinoma. Am. J. Gastroenterol. 1985; 80: 902-906.
14. Ordonez NG, Manning JT. Comparison of alpha-1-antitrypsin and alpha-1-antichymotrypsin in hepatocellular carcinoma: An immunohistochemical study. Am. J. Gastroenterol. 1984; 79: 959-963.
15. Christensen WN, Boitnott JK, Kuhajda FP. Immunoperoxidase staining as a diagnostic aid for hepatocellular carcinoma. Mod. Pathol. 1989; 14: 503-513.
16. Suzuki K, Uchida T, Horiuchi R, Shikata T. Localization of hepatitis B surface and core antigens in human hepatocellular carcinoma by immunoperoxidase methods. Cancer 1985; 56: 321-327.
17. Charlotte F, L'Hermine A, Martin N et al. Immunohistochemical detection of bcl-2 protein in normal and pathological human liver. Am. J. Pathol. 1994; 144: 460-465.
18. Fucich LF, Cheles MK, Thung SN, Gerber MA, Marrogi AJ. Primary vs metastatic hepatic carcinoma: An immunohistochemical study of 34 cases. Arch. Pathol. Lab. Med. 1994; 118: 927-930.
19. Terada T, Nakanuma Y. Development of intrahepatic peribiliary glands: Histological, keratin immunohistochemical and mucus histochemical analyses. Lab. Invest. 1993; 68: 261-269.
20. Terada T, Nakanuma Y. Immunohistochemical demonstration of pancreatic alpha-amylase and trypsin in intrahepatic bile ducts and peribiliary glands. Hepatology 1991; 14: 1129-1135.
21. Terada T, Kono N, Nakanuma Y. Immunohistochemical and immunoelectron microscopical analyses of alpha-amylase isozymes in the intrahepatic biliary epithelium and hepatocytes. J. Histochem. Cytochem. 1992; 40: 1627-1635.
22. Terada T, Nakanuma Y. Expression of alpha-amylase isozymes and trypsin by proliferating epithelium of large intrahepatic bile ducts and intrahepatic peribiliary glands in hepatolithiasis. Histopathology 1993; 22: 467-473.
23. Terada T, Kida T, Nakanuma Y. Extrahepatic peribiliary glands express alpha-amylase isozymes, trypsin and pancreatic lipase: An immunohistochemical analysis. Hepatology 1993; 18: 803-808.
24. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabelled (PAP) procedures. J. Histochem. Cytochem, 1981; 29: 557-580.
25. Ohtsuki M, Yuu H, Maeda M, Saeki S, Yamasaki T, Baba S. Amylase in the lung. Cancer 1977; 39: 1656-1663.
26. Bruns DE, Mills SE, Savory J. Amylase in fallopian tube and serous ovarian neoplasms: Immunohistochemical localization. Arch. Pathol. Lab. Med. 1982; 106: 17-20.
27. Weizel JN, Pooler PA, Mohammed R, Lewitt MD, Eckfeldt JH. A unique case of breast carcinoma producing pancreatic type isoamylase. Gastroenterology 1988; 94: 519-520.
28. Inaji H, Koyama H, Higashiyama M et al. Immunohistochemical, ultrastructural and biochemical studies of an amylase-producing breast carcinoma. Virchows Arch. A Pathol. Anat. Histopathol. 1991; 419: 29-33.