메뉴 건너뛰기




Volumn 16, Issue 1, 1996, Pages 321-326

Tumorigenic behaviour of c-Ha-ras oncogene transfected CaCo 2 cells is associated with increased proteolytic potency

Author keywords

c Ha ras oncogene; CaCo 2; Colorectal carcinoma cell line; Differentiation; Gelatinase; Human; Plasminogen activator; Proliferative potential; Tumorigenicity

Indexed keywords

CHROMOGRANIN A; GELATIN; MUCIN; SUCRASE ISOMALTASE; UROKINASE;

EID: 0030009432     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (1)

References (53)
  • 1
    • 0004210231 scopus 로고
    • Boston: Jones and Bartlett Publishers
    • Cooper GM, ed: Oncogenes. first ed. Boston: Jones and Bartlett Publishers, 1990.
    • (1990) Oncogenes. First Ed.
    • Cooper, G.M.1
  • 2
    • 0020328955 scopus 로고
    • Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene
    • Parada LF, Tabin CJ, Shih C and Weinberg RA: Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 297: 474-478, 1982
    • (1982) Nature , vol.297 , pp. 474-478
    • Parada, L.F.1    Tabin, C.J.2    Shih, C.3    Weinberg, R.A.4
  • 3
    • 0020046441 scopus 로고
    • Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells
    • Goldfarb M, Shimizu K, Perucho M and Wigler M: Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature 290: 404-409, 1982.
    • (1982) Nature , vol.290 , pp. 404-409
    • Goldfarb, M.1    Shimizu, K.2    Perucho, M.3    Wigler, M.4
  • 4
    • 0007625884 scopus 로고
    • Oncogenes in human tumor cell lines: Molecular cloning of a transforming gene from human bladder carcinoma cells
    • USA
    • Pulciani S, Santos E, Lauver AV, Long LK, Robbins KC and Barbacid M: Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells. Proc Natl Acad Sci (USA) 79: 2845-2849, 1982.
    • (1982) Proc Natl Acad Sci , vol.79 , pp. 2845-2849
    • Pulciani, S.1    Santos, E.2    Lauver, A.V.3    Long, L.K.4    Robbins, K.C.5    Barbacid, M.6
  • 6
    • 0027732538 scopus 로고
    • Proteins regulating ras and its relatives
    • Boguski MS and McCormick F: Proteins regulating ras and its relatives. Nature 366: 643-654, 1993.
    • (1993) Nature , vol.366 , pp. 643-654
    • Boguski, M.S.1    McCormick, F.2
  • 7
    • 0026026818 scopus 로고
    • The GTPase superfamily: Conserved structure and molecular mechanism
    • Bourne HR, Sanders DA and McCormick F: The GTPase superfamily: conserved structure and molecular mechanism Nature 349: 117-127, 1991.
    • (1991) Nature , vol.349 , pp. 117-127
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 9
    • 0023619575 scopus 로고
    • A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants
    • Trahey M and McCormick F: A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238: 542-545, 1987.
    • (1987) Science , vol.238 , pp. 542-545
    • Trahey, M.1    McCormick, F.2
  • 11
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER and Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61. 759-767, 1990.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 13
    • 0023262990 scopus 로고
    • Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
    • Forrester K, Almoguera C, Han K, Grizzle WE and Perucho M: Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 327: 298-303, 1987.
    • (1987) Nature , vol.327 , pp. 298-303
    • Forrester, K.1    Almoguera, C.2    Han, K.3    Grizzle, W.E.4    Perucho, M.5
  • 15
    • 0027318554 scopus 로고
    • Increased protein kinase C alpha expression in human colonic CaCo 2 cells after insertion of human Ha-ras or polyoma virus middle T oncogene
    • Delage S, Chastre E, Empereur S, Wicek D, Veissiere D, Capeau J, Gespach C, and Cherqui G: Increased protein kinase C alpha expression in human colonic CaCo 2 cells after insertion of human Ha-ras or polyoma virus middle T oncogene. Cancer Res 53: 2762-2770, 1993.
    • (1993) Cancer Res , vol.53 , pp. 2762-2770
    • Delage, S.1    Chastre, E.2    Empereur, S.3    Wicek, D.4    Veissiere, D.5    Capeau, J.6    Gespach, C.7    Cherqui, G.8
  • 16
    • 0027529827 scopus 로고
    • Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras
    • Medema RH, de Vries-Smits AMM, van der Zon GCM, Maassen JA and Bos JL: Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras. Mol Cell Biol 13. 155-162, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 155-162
    • Medema, R.H.1    De Vries-Smits, A.M.M.2    Van Der Zon, G.C.M.3    Maassen, J.A.4    Bos, J.L.5
  • 17
    • 0027465064 scopus 로고
    • Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts
    • Buday L and Downward J Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts. Mol Cell Biol 13: 1903-1910, 1993.
    • (1993) Mol Cell Biol , vol.13 , pp. 1903-1910
    • Buday, L.1    Downward, J.2
  • 18
    • 0024306658 scopus 로고
    • Growth and transformation of the small intestinal mucosa-importance of connective tissue, gut associated lymphoid tissue and gastrointestinal regulatory peptides
    • Riecken EO, Stallmach A, Zeitz M, Schulzke JD, Menge H and Gregor M: Growth and transformation of the small intestinal mucosa-importance of connective tissue, gut associated lymphoid tissue and gastrointestinal regulatory peptides. Gut 30: 1630-1640, 1989.
    • (1989) Gut , vol.30 , pp. 1630-1640
    • Riecken, E.O.1    Stallmach, A.2    Zeitz, M.3    Schulzke, J.D.4    Menge, H.5    Gregor, M.6
  • 19
    • 9244244860 scopus 로고
    • Identification and biogenesis of intestinal cell-surface components
    • Quaroni A: Identification and biogenesis of intestinal cell-surface components. Progress in Cancer Research and Therapy 29: 267-293, 1984.
    • (1984) Progress in Cancer Research and Therapy , vol.29 , pp. 267-293
    • Quaroni, A.1
  • 21
    • 0024556819 scopus 로고
    • Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells
    • Axelrod JH, Reich R and Miskin R: Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells Mol Cell Biol 9: 2133-2141, 1989.
    • (1989) Mol Cell Biol , vol.9 , pp. 2133-2141
    • Axelrod, J.H.1    Reich, R.2    Miskin, R.3
  • 22
    • 0023109730 scopus 로고
    • Secretion of type IV collagenolytic protease and metastatic phenotype: Induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1 a
    • Garbisa S, Pozzatti R, Muschel RJ, Saffiotti U, Ballin M, Goldfarb RH, Khoury G, and Liotta LA Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1 a. Cancer Res 47: 1523-1528, 1987
    • (1987) Cancer Res , vol.47 , pp. 1523-1528
    • Garbisa, S.1    Pozzatti, R.2    Muschel, R.J.3    Saffiotti, U.4    Ballin, M.5    Goldfarb, R.H.6    Khoury, G.7    Liotta, L.A.8
  • 23
    • 0024548165 scopus 로고
    • Malignant transfer nation of human fibroblasts caused by expression of a transfected T24 HRAS oncogene
    • USA
    • Hurlin PJ, Maher VM and McCormick JJ: Malignant transfer nation of human fibroblasts caused by expression of a transfected T24 HRAS oncogene. Proc Natl Acad Sci (USA) 86: 187-191, 1989
    • (1989) Proc Natl Acad Sci , vol.86 , pp. 187-191
    • Hurlin, P.J.1    Maher, V.M.2    McCormick, J.J.3
  • 24
    • 0025195509 scopus 로고
    • Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells
    • Bernhard EJ, Muschel RJ and Hughes EN: Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells. Cancer Res 50 3872-3877, 1990.
    • (1990) Cancer Res , vol.50 , pp. 3872-3877
    • Bernhard, E.J.1    Muschel, R.J.2    Hughes, E.N.3
  • 26
    • 0020513908 scopus 로고
    • Sucrase-isomaltase: A marker of foetal and malignant epithelial cells of the human colon
    • Zweibaum A, Triadou N, Kedinger M et al: Sucrase-isomaltase: a marker of foetal and malignant epithelial cells of the human colon. Int J Cancer 32: 407-412, 1983.
    • (1983) Int J Cancer , vol.32 , pp. 407-412
    • Zweibaum, A.1    Triadou, N.2    Kedinger, M.3
  • 27
    • 0024424864 scopus 로고
    • Colonic epithelium reactive monoclonal antibodies. Identification and immunohistochemical localization of the target epitopes
    • Verstijnen CPHJ, Arends JW, Moerkerk PTM, Pijls M, Kuypers-Engelen B and Bosman FT: Colonic epithelium reactive monoclonal antibodies. Identification and immunohistochemical localization of the target epitopes. Histochemistry 92 397-406, 1989.
    • (1989) Histochemistry , vol.92 , pp. 397-406
    • Verstijnen, C.P.H.J.1    Arends, J.W.2    Moerkerk, P.T.M.3    Pijls, M.4    Kuypers-Engelen, B.5    Bosman, F.T.6
  • 28
    • 0020562483 scopus 로고
    • Specific endocrine tissue marker defined by a monoclonal antibody
    • Lloyd RV and Wilson BS: Specific endocrine tissue marker defined by a monoclonal antibody. Sciencey 222: 628-630, 1983.
    • (1983) Sciencey , vol.222 , pp. 628-630
    • Lloyd, R.V.1    Wilson, B.S.2
  • 29
    • 0023372129 scopus 로고
    • An improved method for the immunocytochemical detection of bromodeoxyuridine-labeled nudei using flow cytometry
    • Schutte B, Reynders MM, van-Assche CL, Hupperets PS, Bosman FT and Blijham GH. An improved method for the immunocytochemical detection of bromodeoxyuridine-labeled nudei using flow cytometry. Cytometry 8. 372-376, 1987.
    • (1987) Cytometry , vol.8 , pp. 372-376
    • Schutte, B.1    Reynders, M.M.2    Van-Assche, C.L.3    Hupperets, P.S.4    Bosman, F.T.5    Blijham, G.H.6
  • 30
    • 0025610444 scopus 로고
    • New methods for calculating kinetic properties of cells in vitro using pulse labelling with bromodeoxyuridine
    • White RA, Terry N and Meistrich ML: New methods for calculating kinetic properties of cells in vitro using pulse labelling with bromodeoxyuridine. Cell Tissue Kinet 23: 561-573, 1990.
    • (1990) Cell Tissue Kinet , vol.23 , pp. 561-573
    • White, R.A.1    Terry, N.2    Meistrich, M.L.3
  • 31
    • 0022540110 scopus 로고
    • Quantitation of urokinase antigen in plasma and culture media by use of an ELISA
    • Binnema DJ, van Iersel JJL and Dooijewaard G: Quantitation of urokinase antigen in plasma and culture media by use of an ELISA. Thromb Res 43: 569-577, 1986.
    • (1986) Thromb Res , vol.43 , pp. 569-577
    • Binnema, D.J.1    Van Iersel, J.J.L.2    Dooijewaard, G.3
  • 32
    • 0021336784 scopus 로고
    • Quantitation of tissue-type plasminogen activator in human endothelial cell cultures by use of an enzyme immunoassay
    • Rijken DC, van Hinsbergh VWM and Sens EHC: Quantitation of tissue-type plasminogen activator in human endothelial cell cultures by use of an enzyme immunoassay Thromb Res 33: 145-153, 1984.
    • (1984) Thromb Res , vol.33 , pp. 145-153
    • Rijken, D.C.1    Van Hinsbergh, V.W.M.2    Sens, E.H.C.3
  • 35
    • 0020637308 scopus 로고
    • India ink staining of proteins on nitrocellulose paper
    • Hancock K and Tsang VCW: India ink staining of proteins on nitrocellulose paper Anal Biochem 133: 157-162, 1983.
    • (1983) Anal Biochem , vol.133 , pp. 157-162
    • Hancock, K.1    Tsang, V.C.W.2
  • 36
    • 0020316263 scopus 로고
    • Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus
    • Chang EH, Furth ME, Scolnick EM and Lowy DR: Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus. Nature 297: 479-483, 1982.
    • (1982) Nature , vol.297 , pp. 479-483
    • Chang, E.H.1    Furth, M.E.2    Scolnick, E.M.3    Lowy, D.R.4
  • 37
    • 0026317501 scopus 로고
    • Clonal analysis of sucrase-isomaltase expression in the human colon adenocarcinoma CaCo-2 cells
    • Beaulieu J-F and Quaroni A. Clonal analysis of sucrase-isomaltase expression in the human colon adenocarcinoma CaCo-2 cells. Biochem J 280. 599-608, 1991.
    • (1991) Biochem J , vol.280 , pp. 599-608
    • Beaulieu, J.-F.1    Quaroni, A.2
  • 38
    • 0026533045 scopus 로고
    • Ras transformation of simian virus 40-immortalized rat hepatocytes: An in vitro model of hepatocarcinogenesis
    • Fang XJ, Flowers M, Keating A, Cameron R and Sherman M: Ras transformation of simian virus 40-immortalized rat hepatocytes: an in vitro model of hepatocarcinogenesis. Cancer Res 52: 173-180, 1992.
    • (1992) Cancer Res , vol.52 , pp. 173-180
    • Fang, X.J.1    Flowers, M.2    Keating, A.3    Cameron, R.4    Sherman, M.5
  • 39
    • 0026533082 scopus 로고
    • Introduction of the ras oncogene transforms a simian virus 40-immortalized hepatocyte cell line without loss of expression of albumin and other liver-specific genes
    • Isom HC, Woodworth CD, Meng Y, Kreider J, Miller T and Mengel L: Introduction of the ras oncogene transforms a simian virus 40-immortalized hepatocyte cell line without loss of expression of albumin and other liver-specific genes. Cancer Res 52: 940-948, 1992.
    • (1992) Cancer Res , vol.52 , pp. 940-948
    • Isom, H.C.1    Woodworth, C.D.2    Meng, Y.3    Kreider, J.4    Miller, T.5    Mengel, L.6
  • 40
    • 0025275853 scopus 로고
    • c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy
    • Boukamp P, Stanbridge EJ, Foo DY, Cerutti PA and Fusenig NE: c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy. Cancer Res 50: 2840-2847, 1990.
    • (1990) Cancer Res , vol.50 , pp. 2840-2847
    • Boukamp, P.1    Stanbridge, E.J.2    Foo, D.Y.3    Cerutti, P.A.4    Fusenig, N.E.5
  • 41
    • 0021184853 scopus 로고
    • Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein
    • Stacey DW and Kung H-F: Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein Nature 310. 508-511, 1984.
    • (1984) Nature , vol.310 , pp. 508-511
    • Stacey, D.W.1    Kung, H.-F.2
  • 42
    • 0021719520 scopus 로고
    • Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells
    • Feramisco JR, Gross M, Kamata T, Rosenberg M and Sweet RW: Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells Cell 38: 109-117, 1984.
    • (1984) Cell , vol.38 , pp. 109-117
    • Feramisco, J.R.1    Gross, M.2    Kamata, T.3    Rosenberg, M.4    Sweet, R.W.5
  • 43
    • 0027515642 scopus 로고
    • Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability
    • Arends MJ, McGregor AH, Toft NJ, Brown EJH and Wyllie AH: Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability. Br J Cancer 68: 1127-1133, 1993.
    • (1993) Br J Cancer , vol.68 , pp. 1127-1133
    • Arends, M.J.1    McGregor, A.H.2    Toft, N.J.3    Brown, E.J.H.4    Wyllie, A.H.5
  • 44
    • 0028231893 scopus 로고
    • Apoptosis is inversely related to necrosis and determines net growth in tumours bearing constitutively expressed myc, ras, and HPV oncogenes
    • Arends MJ, McGregor AH and Wyllie AH: Apoptosis is inversely related to necrosis and determines net growth in tumours bearing constitutively expressed myc, ras, and HPV oncogenes. Am J Pathol 144: 1045-1057, 1994.
    • (1994) Am J Pathol 1 , vol.44 , pp. 1045-1057
    • Arends, M.J.1    McGregor, A.H.2    Wyllie, A.H.3
  • 45
    • 0023919959 scopus 로고
    • H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen
    • Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Kronberger A, He CS, Bauer EA, and Goldberg GI: H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. J Biol Chem 263: 6579-6587, 1988.
    • (1988) J Biol Chem , vol.263 , pp. 6579-6587
    • Collier, I.E.1    Wilhelm, S.M.2    Eisen, A.Z.3    Marmer, B.L.4    Grant, G.A.5    Kronberger, A.6    He, C.S.7    Bauer, E.A.8    Goldberg, G.I.9
  • 46
    • 0028346025 scopus 로고
    • Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells
    • USA
    • Bernhard EJ, Gruber SB and Muschel RJ: Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci (USA) 91: 4293-4297, 1994.
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 4293-4297
    • Bernhard, E.J.1    Gruber, S.B.2    Muschel, R.J.3
  • 47
    • 0024330327 scopus 로고
    • SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages
    • Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA and Goldberg GI: SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. J Biol Chem 264: 17213-17221, 1989.
    • (1989) J Biol Chem , vol.264 , pp. 17213-17221
    • Wilhelm, S.M.1    Collier, I.E.2    Marmer, B.L.3    Eisen, A.Z.4    Grant, G.A.5    Goldberg, G.I.6
  • 48
    • 0025096722 scopus 로고
    • Multiple modes of activation of latent human fibroblast collagenase: Evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation
    • USA
    • Springman EB, Angleton EL, Birkedal-Hansen H and van Wart HE: Multiple modes of activation of latent human fibroblast collagenase: Evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation. Proc Natl Acad Sci (USA) 87: 364-368, 1990.
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 364-368
    • Springman, E.B.1    Angleton, E.L.2    Birkedal-Hansen, H.3    Van Wart, H.E.4
  • 50
    • 0024334327 scopus 로고
    • Urokinase-type plasminogen activator biosynthesis is induced by the EJ-Ha-ras oncogene in CL26 mouse colon carcinoma cells
    • Testa JE, Medcalf RL, Cajot JF, Schleuning WD and Sordat B: Urokinase-type plasminogen activator biosynthesis is induced by the EJ-Ha-ras oncogene in CL26 mouse colon carcinoma cells. Int J Cancer 43: 816-822, 1989.
    • (1989) Int J Cancer , vol.43 , pp. 816-822
    • Testa, J.E.1    Medcalf, R.L.2    Cajot, J.F.3    Schleuning, W.D.4    Sordat, B.5
  • 51
    • 0024539580 scopus 로고
    • Induction of urokinase activity and malignant phenotype in bladder carcinoma cells after transfection of the activated Ha-ras oncogene
    • K Brunner G, Pohl J, Erkell LJ, Radler-Pohl A and Schirrmacher V: Induction of urokinase activity and malignant phenotype in bladder carcinoma cells after transfection of the activated Ha-ras oncogene. J Cancer Res Clin Oncol 115. 139-144, 1989.
    • (1989) J Cancer Res Clin Oncol , vol.115 , pp. 139-144
    • K Brunner, G.1    Pohl, J.2    Erkell, L.J.3    Radler-Pohl, A.4    Schirrmacher, V.5
  • 53
    • 0027439698 scopus 로고
    • Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumour cells
    • L Sato Hr and Seiki M: Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumour cells. Oncogene 8. 395-405, 1993.
    • (1993) Oncogene , vol.8 , pp. 395-405
    • L Sato, Hr.1    Seiki, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.