On the mechanism and possible therapeutic application of delayed cardiac adaptation to stress

Canadian Journal of Cardiology

Volumn 12, Issue 2, 1996, Pages 177-185

  Szekeres, László ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Cardioprotection; Delayed cardiac adaptation; Ischemic stress; Prostaglandin I2

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENYLATE CYCLASE; CALCIUM ION; CYCLIC AMP; ILOPROST; OUABAIN; PHOSPHODIESTERASE; POTASSIUM ION; PROSTACYCLIN; SODIUM ION;

ADAPTATION; BETA ADRENERGIC STIMULATION; BIOACCUMULATION; DOSE TIME EFFECT RELATION; ENZYME INDUCTION; HEART ARRHYTHMIA; HEART ELECTROPHYSIOLOGY; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART MUSCLE REPERFUSION; HEART PROTECTION; HYDROLYSIS; REVIEW; STRESS;

ADAPTATION, PHYSIOLOGICAL; ADENOSINE TRIPHOSPHATASES; ANIMALS; CYCLIC AMP; HEART; HUMANS; MYOCARDIAL ISCHEMIA; MYOCARDIUM; STRESS; TIME FACTORS;

EID: 0030009187     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (49)

1. Parratt JR. Protection of the heart by ischaemic preconditioning: mechanisms and possibilities for pharmacological evaluation. Trends Pharmacol Sci 1994;15:19-25.
2. Szekeres L, Krassói I, Udvary É. Delayed antuschemic effect of PgI2 and of a new stable PgI2 analogue 7-oxo-prostacyclin-Na in experimental model angina in dogs. J Mol Cell Cardiol 1983;15(Suppl I):394.
3. Udvary É, Végh Á, Szekeres L. 7-oxo-PgI2-induced late appearing and long lasting antiischaemic action in dogs. Pharmacol Res Commun 1988;20 (Suppl 1):171-2.
4. Szekeres L, Pataricza J, Szilvássy Z, Udvary É, Végh Á. Cardioprotection: endogenous protective mechanisms promoted by prostacyclin. Basic Res Cardiol 1991;86(Suppl 3):215-21.
5. Szekeres L, Koltai M, Pataricza J, Takáts I, Udvary E. On the late antiischaemic action of the stable PgI2 analogue: 7-oxo-PgI2-Na and its possible mode of action. Biomed Biochim Acta 1984;43:135-42.
6. Szekeres L, Krassói I, Pataricza J, Udvary É. Delayed antiischaemic effect of prostaglandin 12 and of a new stable prostaglandin 12 analogue, 7-oxo-prostacyclin-Na, in experimental model angina in dogs. In: Dhalla NS, Hearse DJ, eds. Advances in Myocardiology, vol 6. New York: Plenum Press, 1985:607-18.
7. Kovanecz I, Papp JG, Szekeres L. Response to beta adrenergic stimuli is moderated during Iloprost induced delayed and prolonged cardioprotective adaptation. J Mol Cell Cardiol 1994;26:330.
8. Szekeres L, Szilvássy Z., Udvary E, Végh Á. Rapid pacing evoking myocardial ischaemia induces both short-term and delayed cardioprotection. J Mol Cell Cardiol 1991;23(Suppl V):S72,P47.
9. Szekeres L, Papp JG, Szilvássy Z, Udvary É, Végh Á. Moderate stress by cardiac pacing may induce both short term and long term cardioprotection. Cardiovasc Res 1993;27:593-6.
10. Szekeres L. Catecholamines, possible agents for preventive therapy. XV World congress of ISHR, Prague, July 2-7, 1995.
11. Kuzuya T, Hoshida S, Yamashita N, et al. Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia. Circulation Res 1993;72:1293-9.
12. Marber MS, Latchman DS, Walker JM, Yellon DM. Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 1993;88:1264-72.
13. Selye H, Veilleux R, Grasso S. Protection by coronary ligature against isoproterenol-induced myocardial necroses. Proc Soc Exp Biol Med 1960;104:343-5.
14. Rona G, Chappel CI, Balazs T, Gaudry R. An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. Arch Pathol 1959;67:443-5.
15. Dusek J, Rona G, Kahn DS. Myocardial resistance: a study of its development against toxic doses of isoproterenol. Arch Pathol 1970;89:79-83.
16. Poupa O, Turek Z, Pelouch V, Prochazka J, Krofta K. Increased resistance of the myocardium to anoxia in vitro after repeated application to isoprenaline. Physiol Bohemoslov 1965;14:536-41
17. Joseph X, Bloom S, Pledger G, Balázs T. Determinants of resistance to the cardiotoxicity of isoproterenol in rats. Toxicol Appl Pharmacol 1983;69:199-205.
18. Udvary É, Végh Á, Szekeres L. 7-oxo-PgI2 induced late protective action from arrhythmias due to local myocardial ischaemia. Bratisl Lek Listy 1991;92:146-9.
19. Szekeres L, Németh M, Szilvássy Z, Tósaki Á, Udvary É, Végh Á. On the nature and molecular basis of prostacyclin induced late cardiac changes. Biomed Biochim Acta 1988;47:6-11.
20. Szekeres L, Bálint Z, Karcsú S, Tósaki Á, Udvary É. On the 7-oxo-PgI2 induced late appearing long-lasting cytoprotective effect. In: Schrör K, Sinzinger H, eds. Prostaglandins in Clinical Research: Cardiovascular System. New York: Alan R Liss, Inc, 1989:143-7.
21. Szekeres L, Bálint Z, Karcsú S, Tösaki Å. Delayed protection by 7-oxo-PgI2 against cardiac transmembrane ion shifts and early morphological changes due to ischaemia and reperfusion. Cardioscience 1990;1:280-6.
22. Ravingerova T, Tribulova N, Ziegelhöffer A, Dzurba A, Szekeres L. 7-oxo-PgI2 prevents partially the postischemic reperfusion injury of the rat heart. J Mol Cell Cardiol 1991;23(Suppl V):P104.
23. Ravingerová T, Tribulová N, Ziegelhöffer A, Styk J, Szekeres L. Suppression of reperfusion induced arrhythmias in the isolated rat heart: pretreatment with 7-oxo prostacyclin in vivo. Cardiovasc Res 1993;27:1051-5.
24. Ziegelhöffer A, Ravingerova T, Dzurba A, Slezak J, Tribulova N, Szekeres L. High Na/K-ATPase activity induced pretreatment with 7-oxo-prostacyclin (PgI2) is involved in prevention of Ca-paradox (CaP) in the rat heart. J Mol Cell Cardiol 1991;23(Suppl V):P3.
25. Udvary É, Szekeres L. Prostacyclin: antiischaemic or cardioprotective? In: Kecskeméti V, Gyires K, Kovács G, eds. Advances in Pharmacological Research and Practice, volume 3, section 7. Prostanoids. Budapest: Akadémiai Kiadó, 1986 333-8.
26. Szekeres L, Németh M, Papp JG, Udvary É, Végh A, Virág L. Neue Entwicklungen der antiarrhythmischen Therapie. In: Lüderitz B, Antoni B, eds. Perspektiven der Arrhythmiebehandlung. Berlin: Springer Verlag, 1988:24-34.
27. Végh Á. 7-oxo-PgI2 induced delayed protective action from late postocclusion arrhythmias in conscious dogs. In: Abstracts, East European Subsection Meeting, International Society for Heart Research, May 13-18, Smolenice CSR, 1990:93.
28. Szekeres L, Szilvássy Z, Udvary É, Végh Á. 7-oxo-PgI2 induced late appearing protection against ouabain induced cardiac arrhythmias in anesthetized guinea pigs. Pharmacol Res Commun 1988;20:77-8.
29. Szilvássy Z, Szekeres L, Udvary É, Végh A. On the 7-oxo-PgI2 induced lasting protection against ouabain arrhythmias in anesthetized guinea pigs. Biomed Biochim Acta 1988;47(Suppl):35-8.
30. Szilvássy Z, Szekeres L, Udvary É, Karcsú S, Végh Á. 7-oxo-PgI2 dramatically increases the safety margin of digitalis. Bratisl Lek Listy 1991;92:134-7.
31. Vegh A, Papp JG, Kasala K, Parratt JR. Cardiac pacing in anaesthetized dogs preconditions the heart against arrhythmias when ischaemia is induced 24 h later. J Physiol 1994;480:89P.
32. Ravingerova T, Styk J, Trégerova V, et al. Protective effect of 7-oxo-prostacyclin on myocardial function and metabolism during postischemic reperfusion and calcium paradox. Basic Res Cardiol 1991;86:245-53.
33. Szekeres L, Németh M, Papp JG, Szilvássy Z, Udvary É, Végh Á. On the late appearing cardiac electrophysiological actions of the stable prostacyclin analogue: 7-oxo-PgI2-Na. Proceedings of the 10th International Congress of Pharmacology, Sydney, 1987:156.
34. Németh M, Papp JG, Szekeres L. Class 3 antiarrhythmic features of 7-oxo-PgI2, a stable analogue of prostacyclin. Eur Heart J 1988;9(Suppl):232.
35. Szekeres L, Szilvássy Z, Udvary É, Végh Á. 7-oxo-PgI2 induced late appearing and long-lasting electrophysiological changes in the heart in situ of the rabbit, guinea pig, dog and cat. J Mol Cell Cardiol 1989;21:545-54.
36. Szekeres L, Németh M, Papp JG, Udvary É. Short incubation with 7-oxo-prostacyclin induces long lasting prolongation of repolarisation time and effective refractory period in rabbit papillary muscle preparation. Cardiovasc Res 1990;24:37-41.
37. Yellon D. Delayed myocardial preconditioning: the role of stress proteins. In: Parratt J, Thiemermann C, eds. William Harvey Research Conferences: Cardiac Preconditioning: Novel Approaches for Prevention and Treatment of Myocardial Ischaemia. London: William Harvey Research Institute, 1994:10.
38. Szekeres L. Delayed cardioprotective effects of prostacyclins and other benign stresses. In: Parratt J, Thiemermann C, eds. William Harvey Research Conferences: Cardiac Preconditioning: Novel Approaches for Prevention and Treatment of Myocardial Ischaemia. London: William Harvey Research Institute, 1994:12.
39. Szekeres L. Possible stages of adaptive remodeling of myocardial cells. In: Nagano M, Takeda N, Dhalla NS, eds. The Cardiomyopathic Heart. New York: Raven Press, 1994:237-45.
40. Krause E-G, Bartel S, Luthardt G, Szilvássy Z, Szekeres L. The protective effect of 7-oxo-prostacyclin (7-oxo) is related to a rise in particulate cGMP-hydrolysing PDE activity in the myocardium. J Mol Cell Cardiol 1990;22(Suppl 3):33.
41. Borchert G, Bartel S, Beyerdörfer I, Küttner I, Szekeres L, Krause EG. Long lasting anti-adrenergic effect of 7-oxo-prostacyclin in the heart: a cycloheximide sensitive increase of phosphodiesterase isoform I and IV activities. Mol Cell Biochem 1994;132:57-67.
42. Dzurba A, Ziegelhöffer A, Breier A, Vrbjar N, Szekeres L. Increased activity of sarcolemmal (Na+ K+)- ATPase is involved in the late cardioprotective action of 7-oxo-prostacyclin. Cardioscience 1991;2:105-8.
43. Opie LH. Role of cyclic nucleotides in heart metabolism. Cardiovascular Research 1982;16:483-507.
44. Thandroyen FT, Muntz KH, Buja LM, Willerson JT. Alterations in beta-adrenergic receptors, adenylate cyclase, and cyclic AMP concentrations during acute myocardial ischemia and reperfusion. Circulation 1990;82(Suppl II): II30-I7.
45. Meng X, Brown JM, Ao L, Mitchell MB, Banerjee A, Harken AH. Norepinephrine induces late cardiac protection preceded by oncogene and heat shock protein gene overexpression. Circulation 1993;88. (Abst 3407).
46. Szekeres L, Tósaki Á. Release of 6-keto-PgFlalfa and thromboxane BZ in late appearing cardioprotection induced by the stable PgI analogue: 7-oxo-PgI. Mol Cell Biochem 1993;119:129-32.
47. Ziegelhöffer A, Grünermel J, Dzurba A, et al. Sarcolemmal cation transport systems in rat hearts acclimatized to high altitude hypoxia: influence of 7-oxo-prostacyclin. In: Ostádal B, Dhalla NS, eds. Heart Function in Health and Disease. Boston: Kluwer Academic Publishers, 1993:219-28.
48. Szekeres L, Németh M, Papp JG. 7-oxo-prostacyclin induced late appearing microelectrophysiological changes in normoxic and ischaemic rabbit papillary muscle preparation. J Mol Cell Cardiol 1993;25(Suppl 1): S71.
49. Krause EG, Szekeres L. On the mechanism and possible therapeutic application of delayed adaptation of the heart to stress situations. Mol Cell Biochem. (In press)