Oral tolerance in EAE: Reversal of tolerance by T helper cell cytokines

Journal of Neuroimmunology

Volumn 66, Issue 1-2, 1996, Pages 77-84

  Kelly, Kathleen A ^a   Whitacre, Caroline C ^b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

antibody forming cells; ELISPOT; experimental autoimmune encephalomyelitis; myelin basic protein; oral tolerance

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; INTERLEUKIN 4; INTERLEUKIN 5; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030009046     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-5728(96)00027-6     Document Type: Article

References (47)

1. Armaki, Y., Fujii, Y., Suda, H., Suzuki, I., Yadomae, T. and Tsuchiya, S. (1994) Induction of oral tolerance after feeding of ragweed pollen extract in mice. Immunol. Letters 40, 21-25.
2. Bitar, D.M. and Whitacre, C.C. (1988) Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein. Cell. Immunol. 112, 364-370.
3. γ producing (Th1) cells. J. Immunol. 148, 3687-3691.
4. Challacombe, S.J. and Tomasi, T.B. (1980) Systemic tolerance and secretory immunity after oral immunization. J. Exp. Med. 152, 1459-1472.
5. Chiller, J.M. and Glasebrook, A.L. (1988) Oral tolerance and the induction of T cell unresponsiveness. In: L.A. Hanson and C. Svanborg-Eden (Eds.), Mucosal Immunobiology Cellular-Molecular Interactions in the Mucosal Immune System, Mongr. Allergy, Vol. 24, Karger, Basel, pp. 256-265.
6. Coffman, R.L., Seymour, B.W.P., Lebman, D.A., Hiraki, D.D., Christiansen, J.A., Shrader, B., Cherwinski, H.M., Savelkoul, H.F.J., Finkelman, F.D., Bond, M.W. and Mosmann T.R. (1988) The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102, 5-28.
7. Coffman, R.L., Lebman, D.A. and Shrader, B. (1989) Transforming growth factor β specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Exp. Med. 170, 1039-1044.
8. Cowdrey, J.S. and Johlin, B.J. (1984) Regulation of the primary in vitro response to TNP-polymerized OVA by T-suppressor cells induced by OVA feeding. J. Immunol. 132, 2783-2789.
9. David, M.F. (1979) Induction of hyporesponsiveness to particulate antigen by feeding: the sequence of immunologic response to fed antigen. J. Allergy Clin. Immunol. 64, 164-172.
10. Day, E.D. and Pitts, O.M. (1974) The antibody response to myelin basic protein (BP) in Lewis rats: The effect of time, dosage of MBP, and dosage of Mycobacterium butyricum. J. Immunol. 133, 1958-1967.
11. Fishman-Lobell, J., Friedman, A. and Weiner, H.L. (1994) Different kinetic patterns of cytokine gene expression in vivo in orally tolerant mice. Eur. J. Immunol. 24, 2720-2724.
12. Friedman A. and Weiner, H.L. (1994) Induction of anergy or active suppression in oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Sci. USA 91, 6688-6692.
13. Frangakis, M.V., Koopman, W.J., Kiyono, H., Michalek, S.M. and McGhee, J.R. (1982) An enzymatic method for preparation of dissociated murine Payer's patch cells enriched for macrophages. J. Immunol. Methods 48, 33-44.
14. Fuller, K.A., Pearl, D. and Whitacre, C.C. (1990) Oral tolerance in experimental autoimmune encephalomyelitis: serum and salivary antibody responses. J. Neuroimmunol. 28, 15-26.
15. Groome, N.P. (1980) Enzyme-linked immunoadsorbent assays for myelin basic protein and antibodies to myelin basic protein. J. Neurochem. 35, 1409-1417.
16. Hanson, D.G., Vaz, N.M., Maia, L.C.S., Hornbrook, M.M., Lynch, J.M. and Roy, C.A. (1977) Inhibition of specific immune responses by feeding protein antigens. Int. Archs. Allergy Appl. Immunol. 55, 526-532.
17. Higgins, P.J. and Weiner, H.L. (1988) Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J. Immunol. 140, 440-445.
18. Husby, S., Mestecky, J., Moldoveanu, A., Holland, S. and Elson, C.O. (1994) Oral Tolerance in Humans. T cell but not B cell tolerance after antigen feeding. J. Immunol. 152, 4664-4670.
19. Jabara, H.H., Schnieder, L.C., Shapira, S.K., Alfieri, C., Moody, C.T., Kieff, E., Geha, R.S. and Vercelli, D. (1990) Induction of germ-line and mature Ce transcripts in human B cells stimulated with rIL-4 and EBV. J. Immunol. 145, 3468-3473.
20. Kagnoff. M.F. (1978a) Effects of antigen-feeding on intestinal and systemic immune responses II. Suppression of delayed-type hypersensitivity reactions. J. Immunol. 120, 1509-1513.
21. Kagnoff, M.F. (1978b) Effects of antigen-feeding on intestinal and systemic immune responses. III. Antigen specific serum-mediated suppression of humoral antibody responses after antigen feeding. Cell. Immunol. 40, 186-203.
22. Kagnoff, M.F. (1982) Oral tolerance. Ann. NY Acad. Sci. 392, 248-265.
23. Kurt-Jones, E.A., Hamberg, S., Ohara, J., Paul, W.E. and Abbas, A.K. (1987) Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J. Exp. Med. 166, 1774-87.
24. + T lymphocytes. J. Immunol. 142, 748-752.
25. Lafont, S., Andre, C., Andre, F., Gillon, J. and Fargier, M.-C. (1982) Abrogation by subsequent feeding of antibody response, including IgE, in parenterally immunized mice. J. Exp. Med. 155, 1573-1578.
26. Lebman, D.A. and Coffman, R.L. (1988) Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures. J. Exp. Med. 168, 853-862.
27. Mattingly, J.A. and Waksman, B.H. (1978) Immunologic suppression after oral administration of antigen. I. Specific suppressor cells formed in rat Peyer's patches after oral administration of sheep erythrocytes and their systemic migration. J. Immunol. 121, 1878-1883.
28. Mattingly, J.A. (1984) Immunologic suppression after oral administration of antigen. III. Activation of suppressor-inducer cells in the Peyer's patches. Cell. Immunol. 86, 46-52.
29. Melamed, D. and Friedman, A. (1994) In vivo tolerization of Th1 lymphocytes following a single feeding with ovalbumin: anergy in the absence of suppression. Eur. J. Immunol. 24, 1974-1981.
30. β after antigen specific triggering. Proc. Natl. Acad. Sci. USA. 89, 421-425.
31. Moller, S.A. and Borrebaeck, C.A.K. (1985) A filter immuno-plaque assay for the detection of antibody-secreting cells in vitro. J. Immunol. Methods 79, 195-204.
32. Mowat, A. Mcl. (1987) The regulation of immune responses to dietary protein antigens. Immunol. Today 8, 93-98.
33. Ngan, J. and Kind, L.S. (1978) Suppressor T cells for IgE and IgG in Peyer's patches of mice made tolerant by the oral administration of ovalbumin. J. Immunol. 120, 861-865.
34. Ortiz-Ortiz, L. and Weigle, W.O. (1976) Cellular events in the induction of experimental allergic encephalomyelitis in rats. J. Exp. Med. 144, 604-616.
35. Paterson, P.Y. (1976) Experimental autoimmune (allergic) encephalomyelitis: induction, pathogenesis and suppression. In: P.A. Miescher and H.J. Muller-Eberhard (Eds.), Textbook of Immunopathology, 2nd edn., Grune and Straton, New York, pp. 179-213.
36. Paterson, P.Y. (1977) Autoimmune neurologic disease: experimental animal systems and implications for multiple sclerosis. In: N. Talal (Ed.), Autoimmunity; Genetic, Immunologic, Virologie and Clinical aspects, Academic Press, New York, pp. 643-692.
37. Richman, L.K., Chiller, J.M., Brown, W.R., Hanson, D.G. and Vaz, N.M. (1978) Enterically induced immunologic tolerance. I. Induction of suppressor T lymphocytes by intragastric administration of soluble proteins. J. Immunol. 121, 2429-2434.
38. Swanborg, R.H., Swierkosz, J.E. and Saieg, R.G. (1974) Studies on the species variability of EAE in guinea pigs and rats. J. Immunol. 112, 594-600.
39. Titus, R.G. and Chiller, J.M. (1981) Orally induced tolerance: definition at the cellular level. Int. Archs. Allergy Appl. Immunol. 65, 323-338.
40. Tomasi, T.B. (1980) Oral tolerance. Transplantation 29, 353-356.
41. Taudorf, E., Laursen, L.C., Lanner, A., Bjorksten, B., Dreborg, S., Soborg, M. and Weeke, B. (1987) Oral immunotherapy in birch pollen hay fever. J. Allergy Clin. Immunol. 80, 153-161.
42. Vaz, N.M., Maia, L.C.S., Hanson, D.G. and Lynch, J.M. (1977) Inhibition of homocytotropic antibody responses in adult inbred mice by previous feeding of the specific antigen. J. Allergy Clin. Immunol. 60, 110-115.
43. Wang, Z-Y., Oiao, J. and Link, H. (1993) Suppression of experimental autoimmune myasthenia gravis by oral administration of acetylcholine receptor. J. Neuroimmunol. 44, 209-214.
44. Weiner, H.L., Mackin, G.A., Matsue, M., Orav, E.J., Khoury, S.J., Dawson, D.M. and Hafler, D.A. (1993) Double-blind pilot trial of oral tolerization with myelin antigens in muliple sclerosis. Science 259, 1321-1324.
45. Weiner, H.L., Friedman, A., Miller, A., Khoury, S.J., Al-Sabbagh, A., Santos, L., Sayegh, M., Nussenblatt, R.B., Trentham, D.E. and Hafler, D.A. (1994) Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12, 809-837.
46. Whitacre, C.C., Gienapp, I.E., Orosz, C.G. and Bitar, D.M. (1991) Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy. J. Immunol. 147, 2155-2163.
47. Xu-Amano, J., Aicher, W.K., Taguchi, T., Kiyono, H. and McGhee, J.R. (1992) Selective induction of Th2 cells in murine Peyer's patches by oral immunization. International Immunology 4, 433-445.