Differential single- versus double-strand DNA breakage produced by doxorubicin and its morpholinyl analogues

Cancer Chemotherapy and Pharmacology

Volumn 38, Issue 3, 1996, Pages 210-216

  Duran, George E ^a   Lau, Derick H M ^a   Lewis, Alexander D ^a   Kühl, Jörn S ^a   Bämmler, Theodor K ^a   Sikic, Branimir I ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anthracyclines; DNA strand breakage; Morpholinyl doxorubicin; MX2; Topoisomerases

Indexed keywords

ANTHRACYCLINE DERIVATIVE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; DOXORUBICIN; DOXORUBICIN DERIVATIVE; METHOXYMORPHOLINYL DOXORUBICIN; MORPHOLINYL DOXORUBICIN; MORPHOLINYL OXAUNOMYCIN; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; OVARY CARCINOMA; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS;

ANTIBIOTICS, ANTINEOPLASTIC; CARCINOMA; CARUBICIN; DNA; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA, NEOPLASM; DNA, SINGLE-STRANDED; DOXORUBICIN; ELECTROPHORESIS, AGAR GEL; ELECTROPHORESIS, GEL, PULSED-FIELD; FEMALE; HUMANS; OVARIAN NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0030008790     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050473     Document Type: Article

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