Halothane and Isoflurane Inhibit Vasodilation Due to Constitutive but Not Inducible Nitric Oxide Synthase: Implications for the Site of Anesthetic Inhibition of the Nitric Oxide/Guanylyl Cyclase Signaling Pathway

Anesthesiology

Volumn 84, Issue 5, 1996, Pages 1156-1165

  Zuo, Zhiyi ^b   Tichotsky, Alexandra ^b   Johns, Roger A ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b NONE

Author keywords

Anesthetics, volatile: halothane; isoflurane; Artery, endothelium: endothelium derived relaxing factor; nitric oxide; Enzymes, nitric oxide synthase: endothelial; inducible; Nucleotides: cyclic guanosine 3,5 monophosphate

Indexed keywords

CYCLIC GMP; DRUG RECEPTOR; ENDOTHELIUM DERIVED RELAXING FACTOR; GUANYLATE CYCLASE; HALOTHANE; ISOFLURANE; LIPOPOLYSACCHARIDE; METHACHOLINE; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE;

ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; INHALATION ANESTHESIA; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; THORACIC AORTA; VASODILATATION;

ANESTHETICS, INHALATION; ANIMALS; ARGININE; CELLS, CULTURED; CYCLIC GMP; ENDOTHELIUM, VASCULAR; GUANYLATE CYCLASE; HALOTHANE; ISOFLURANE; MALE; MICE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

EID: 0030007976     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199605000-00018     Document Type: Article

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